公开(公告)号：US20200171215A1

公开(公告)日：2020-06-04

申请号：US16616418

申请日：2018-05-31

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Pamela Gehron Robey ,  Sergei Kuznetsov ,  Raphael Gorodetsky ,  Astar Hailu-Lazmi ,  Mitchell Shirvan ,  Joseph Featherall

IPC: A61L31/16 ,  A61L31/04 ,  A61K45/06

Abstract: Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.

公开(公告)号：US20200163695A1

公开(公告)日：2020-05-28

申请号：US16623054

申请日：2018-06-17

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD

Inventor： Ran ELIAZ ,  Yonathan Avraham DEMMA ,  Ziv MENSHES ,  Or HAZAN ,  Eva ABRAMOV ,  Yaakov NAHMIAS ,  Amnon BUXBOIM ,  Yoav KAN-TOR ,  Yoav MINTZ ,  Elchanan FRIED

IPC: A61B17/34 ,  A61B17/00

Abstract: Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.

公开(公告)号：US20200032204A1

公开(公告)日：2020-01-30

申请号：US16484420

申请日：2018-02-08

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Benjamin E. Reubinoff ,  Masha Gorshtein ,  Hanita Khaner ,  Alex Obolensky ,  Eyal Banin

IPC: C12N5/0793 ,  A61K35/30

Abstract: A method of generating photoreceptor cells is disclosed. Cell populations comprising photoreceptor cells and uses thereof are also disclosed.

公开(公告)号：US20190389799A1

公开(公告)日：2019-12-26

申请号：US16553647

申请日：2019-08-28

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  INDIAN INSTITUTE OF SCIENCE

Inventor： Bernard LERER ,  Mugesh GOVINDASAMY ,  Tzuri LIFSCHYTZ

IPC: C07D207/456 ,  A61P35/00 ,  A61P25/24 ,  C07D517/04 ,  C07D405/06

Abstract: The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.

公开(公告)号：US10478476B2

公开(公告)日：2019-11-19

申请号：US15763550

申请日：2016-09-29

Applicant: Hadasit Medical Research Services and Development Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Amir Haze ,  Anat Blumenfeld ,  Dan Deutsch

IPC: A61K38/00 ,  A61K38/16 ,  A61K38/28 ,  A61K38/39 ,  A61K38/18 ,  A61K38/30 ,  A61K45/06

Abstract: A method of promoting nerve growth or regeneration in a subject in need thereof, wherein the subject is not afflicted with a substantial connective tissue damage, is provided. The method comprises administering to the subject a therapeutically effective amount of full-length amelogenin, thereby promoting nerve growth or regeneration in the subject.

公开(公告)号：US20190070111A1

公开(公告)日：2019-03-07

申请号：US16184079

申请日：2018-11-08

Applicant: Hadasit Medical Research Services and Development Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Ruth GABIZON ,  Haim OVADIA ,  Oded ABRAMSKY ,  Shlomo MAGDASSI ,  Liraz LARUSH

IPC: A61K9/107 ,  A61K47/44 ,  A61K47/26 ,  A61K47/24 ,  A61K47/22 ,  A61K47/14 ,  A23L33/115 ,  A61K45/06 ,  A61K36/185 ,  A61K31/202 ,  A61K47/10

Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).

公开(公告)号：US10154961B2

公开(公告)日：2018-12-18

申请号：US14523408

申请日：2014-10-24

Applicant: Hadasit Medical Research Services and Development Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Ruth Gabizon ,  Haim Ovadia ,  Oded Abramsky ,  Shlomo Magdassi ,  Liraz Larush

IPC: A61K9/107 ,  A61K31/202 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61K36/185 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A23L33/115

Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).

公开(公告)号：US20180200324A1

公开(公告)日：2018-07-19

申请号：US15743056

申请日：2016-07-21

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Or KAKHLON ,  Amit MICHAELI

IPC: A61K38/07 ,  C07K5/113 ,  C07K5/103 ,  A61P3/08

CPC classification number: A61K38/07 ,  A61K38/00 ,  A61K49/0056 ,  A61P3/08 ,  C07K5/101 ,  C07K5/1021

Abstract: The present invention discloses a peptide capable of stabilizing mutation-induced GBE1 protein destabilization, conjugates comprising same and uses thereof for the treatment of diseases and disorders associate with glycogen storage.

公开(公告)号：US20180186861A1

公开(公告)日：2018-07-05

申请号：US15899621

申请日：2018-02-20

Applicant: Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. ,  Hadasit Medical Research Services And Development Ltd.

Inventor： Dan DEUTSCH ,  Amir HAZE ,  Anat BLUMENFELD

IPC: C07K14/78 ,  A61K38/39

CPC classification number: C07K14/78 ,  A61K38/39

Abstract: A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of amelogenin.

公开(公告)号：US10000549B2

公开(公告)日：2018-06-19

申请号：US15178085

申请日：2016-06-09

Applicant: KAHR MEDICAL LTD ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Michal Dranitzki Elhalel

IPC: C07K16/28 ,  C07K14/705 ,  A61K38/17

CPC classification number: C07K14/70575 ,  A61K38/1774 ,  C07K14/70521 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/33

Abstract: Use of a chimeric protein selected from the group consisting of CTLA4-FasL and CD40-FasL proteins for treatment of lymphoma and/or a multiple myeloma and/or a leukemia as described herein, and pharmaceutical compositions and methods of treatment thereof.