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    Receptor tyrosine kinase with a discoidin-type binding domain
    56.
    发明授权
    Receptor tyrosine kinase with a discoidin-type binding domain 失效
    具有盘状蛋白型结合结构域的受体酪氨酸激酶

    公开(公告)号：US06627733B2

    公开(公告)日：2003-09-30

    申请号：US09140378

    申请日：1998-08-26

    Applicant: Jeffrey D. Johnson ,  William J. Rutter ,  Jeffrey C. Edman

    Inventor： Jeffrey D. Johnson ,  William J. Rutter ,  Jeffrey C. Edman

    IPC: C07K100

    CPC classification number: G01N33/57488 ,  A61K38/45 ,  A61K39/00 ,  C07K14/705 ,  C12Q1/485 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/68

    Abstract: A breast carcinoma tyrosine phosphoprotein, DDR (Discoidin Domain Receptor), that defines a novel class of receptor tyrosine kinases is presented. The DDR cDNA predicts a polypeptide C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region suggests an unusual geometry of interaction with ligand or substrates. Discoidin I-type domains may interact with specific cell surface molecules.

    Abstract translation: 提出了定义一类新型受体酪氨酸激酶的乳腺癌酪氨酸磷酸蛋白DDR（盘丝蛋白结构域受体）。 DDR cDNA预测多肽C末端酪氨酸激酶结构域和类似于盘基网柄菌滴定凝集素盘状蛋白I的N末端结构域。这些结构域通过非常亲水脯氨酸/甘氨酸富集结构域连接，其被预测的跨膜序列 。 这种延长的脯氨酸/富含甘氨酸的区域表明与配体或底物相互作用的异常几何形状。 盘丝蛋白I型结构域可能与特定的细胞表面分子相互作用。

    Stand alone water purifier
    57.
    发明授权
    Stand alone water purifier 有权
    独立净水器

    公开(公告)号：US06500334B1

    公开(公告)日：2002-12-31

    申请号：US09628637

    申请日：2000-07-31

    Applicant: Joseph A. King ,  Jeffrey D. Johnson

    Inventor： Joseph A. King ,  Jeffrey D. Johnson

    IPC: C02F100

    CPC classification number: B01F1/0027 ,  B01F5/0413 ,  B01F5/0496 ,  C02F1/50 ,  C02F1/688 ,  C02F2103/003 ,  C02F2103/42 ,  C02F2303/04 ,  Y10T137/4891

    Abstract: A water purification device, method and system with the water purification device having a container for holding a water purification material therein with the water purification device including a shroud extending in a direction generally normal to a flow of debris laden water with the shroud inhibiting direct flow of debris into a water inlet in the water purification device by directing water and debris over the shroud and around the water purification device while a portion of the water can be directed laterally into the water purification material within the water purification device to thereby purify the water that flows over the water purification materials with the water purification device including multiple spaced and positioned water inlets so that the likelihood of the water inlet being completely obstructed is remote.

    Abstract translation: 一种水净化装置，方法和系统，其中所述净水装置具有用于在其中保持水净化材料的容器，所述水净化装置包括沿着大体垂直于载满碎屑的水流的方向延伸的护罩，所述护罩禁止直流 通过将水和碎屑引导到护罩上和水净化装置周围，将一部分水横向地引导到水净化装置内的净水材料中，从而净化水分，从而将水分和碎屑引导到水净化装置的入水口中 水净化装置通过多个间隔定位的进水口在水净化装置上流动，使得进水口完全阻塞的可能性是远距离的。

    R/2R' ladder switch circuit and method for digital-to-analog converter
    58.
    发明授权
    R/2R' ladder switch circuit and method for digital-to-analog converter 有权
    R / 2R'梯形开关电路和数模转换器的方法

    公开(公告)号：US06150971A

    公开(公告)日：2000-11-21

    申请号：US337796

    申请日：1999-06-22

    Applicant: Jimmy R. Naylor ,  Timothy V. Kalthoff ,  Mark A. Shill ,  Jeffrey D. Johnson

    Inventor： Jimmy R. Naylor ,  Timothy V. Kalthoff ,  Mark A. Shill ,  Jeffrey D. Johnson

    IPC: H03M1/78 ,  H03K17/00 ,  H03K17/693 ,  H03M1/08

    CPC classification number: H03M1/089 ,  H03M1/785

    Abstract: A digital-to-analog converter includes a resistive divider network including a plurality of series resistors of resistance R and a plurality of shunt resistors of resistance 2R' and a circuit for switching a shunt resistor of the resistive divider network in the digital-to-analog converter to either of first and second reference voltages. The switching circuit includes a first switch MOSFET coupling the low reference voltage to the shunt resistor, and a second switch MOSFET coupling the shunt resistor to the high reference voltage. First and second switch control circuits adjust the on resistances of the first and second switch MOSFETs to be proportional to the resistances of first and second reference resistors, which have the same temperature coefficient as the resistors of which the divider network is composed. The on resistance of each of the first and second switch MOSFETs is equal to R.sub.ONi, and the resistance 2R' is equal to 2R-R.sub.ONi. The on resistances do not need to be binarily scaled.

    Abstract translation: 数模转换器包括电阻分压网络，其包括电阻R的多个串联电阻器和多个电阻2R'的分流电阻器，以及用于在数模转换器中切换电阻分压器网络的分流电阻器的电路， 模拟转换器到第一和第二参考电压中的任一个。 开关电路包括将低参考电压耦合到分流电阻器的第一开关MOSFET和将分流电阻器耦合到高参考电压的第二开关MOSFET。 第一和第二开关控制电路将第一和第二开关MOSFET的导通电阻调节成与第一和第二参考电阻的电阻成比例，第一和第二参考电阻具有与构成分压网络的电阻相同的温度系数。 第一和第二开关MOSFET的导通电阻等于RONi，电阻2R'等于2R-RONi。 导通电阻不需要二进制缩放。

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