公开(公告)号：US6106812A

公开(公告)日：2000-08-22

申请号：US231042

申请日：1999-01-13

Applicant: Michael Prencipe ,  Mike Wong ,  Vincent O. Drago ,  Marcus Bentley ,  Mahmoud Hassan ,  Nagaraj S. Dixit

Inventor： Michael Prencipe ,  Mike Wong ,  Vincent O. Drago ,  Marcus Bentley ,  Mahmoud Hassan ,  Nagaraj S. Dixit

IPC: A61K8/22 ,  A61K8/24 ,  A61K8/73 ,  A61K8/81 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/20

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/24 ,  A61K8/73 ,  A61K8/8147 ,  A61K2800/88

Abstract: A dual component tooth whitening composition is disclosed, which composition contains a peroxide whitening and a second ingredient incompatible with the peroxide compound, the second ingredient and the peroxide compound each being incorporated in separate dentifrice components which are physically separated until dispensed for use, the components retaining their original physical state when in contact, the first component being a composition containing a peroxide whitening compound in a vehicle thickened with a combination of a particulated water insoluble inorganic compound and an organic thickener other than an alkylene oxide polymer, and the second component containing the ingredient incompatible with the peroxide.

Abstract translation: 公开了双组分牙齿增白组合物，该组合物含有过氧化物增白剂和与过氧化物化合物不相容的第二成分，第二成分和过氧化合物各自被并入分离的洁齿剂组分中，这些成分物理分离直到分配使用，组分 在接触时保持其原始的物理状态，第一组分是在混合有不溶于水的不溶性无机化合物和除了烯化氧聚合物之外的有机增稠剂的混合物中加入过氧化物增白化合物的组合物，和含有 该成分与过氧化物不相容。

公开(公告)号：US5976507A

公开(公告)日：1999-11-02

申请号：US90293

申请日：1998-06-04

Applicant: Mike Wong ,  Michael Prencipe

Inventor： Mike Wong ,  Michael Prencipe

IPC: A61K8/21 ,  A61K20060101 ,  A61K8/11 ,  A61K8/20 ,  A61K8/73 ,  A61K9/48 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC classification number: A61Q11/00 ,  A61K8/11 ,  A61K2800/412 ,  A61K2800/88

Abstract: An aqueous dentifrice composition comprising an aqueous vehicle containing at least two active ingredients reactive with each other, at least one of the active ingredients being encapsulated in a substantially water immiscible, pressure rupturable shell which is rupturable during use of the dentifrice, causing the same to be released for interaction with the other active ingredient, the shell being formed from a plasticized alkyl cellulose polymer. The dentifrice exhibits increased efficacy for fluoridation of teeth when the active ingredients are soluble fluoride salt and a calcium salt encapsulated in the plasticized alkyl cellulose polymer.

Abstract translation: 一种含水洁牙剂组合物，其包含含有至少两种彼此反应的活性成分的水性载体，所述活性成分中的至少一种被包封在基本上不与水混溶的压力破裂的壳体中，所述壳体在使用洁齿剂期间是可破裂的， 被释放以与其它活性成分相互作用，壳由增塑的烷基纤维素聚合物形成。 当活性成分是可溶性氟化物盐和包封在增塑的烷基纤维素聚合物中的钙盐时，洁牙剂表现出增加的牙齿氟化功效。

公开(公告)号：US5939051A

公开(公告)日：1999-08-17

申请号：US31727

申请日：1998-02-27

Applicant: John Santalucia ,  Peter Ren ,  Nagaraj Dixit ,  Gary Durga ,  Michael Prencipe ,  Mahmoud Hassan ,  Marcus Bentley ,  Barry Self

Inventor： John Santalucia ,  Peter Ren ,  Nagaraj Dixit ,  Gary Durga ,  Michael Prencipe ,  Mahmoud Hassan ,  Marcus Bentley ,  Barry Self

IPC: A61K8/04 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC classification number: A61K8/042 ,  A61K8/25 ,  A61Q11/00

Abstract: Oral compositions, such as oral gels and toothpastes, containing a novel high cleaning, low abrasion silica hydrogel abrasive.

Abstract translation: 口服组合物，例如口服凝胶和牙膏，含有新型高清洁，低磨损的二氧化硅水凝胶研磨剂。

公开(公告)号：US5851514A

公开(公告)日：1998-12-22

申请号：US692841

申请日：1996-08-02

Applicant: Mahmoud Hassan ,  Nagaraj Dixit ,  Michael Prencipe ,  David B. VIscio ,  Salim A. Nathoo

Inventor： Mahmoud Hassan ,  Nagaraj Dixit ,  Michael Prencipe ,  David B. VIscio ,  Salim A. Nathoo

IPC: A61K20060101 ,  A61K8/22 ,  A61K8/24 ,  A61K8/39 ,  A61K8/90 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/24 ,  A61K8/39 ,  A61K8/90 ,  A61K2800/51

Abstract: An aqueous abrasive whitening composition containing a peroxide whitening compound which is chemically and physically stable and exhibits heightened and rapid whitening of teeth and stain removal which comprises a combination of water, abrasive and peroxide compounds, a humectant containing a polyethylene glycol, a polyoxyethylene-polyoxypropylene block copolymer, a metal ion complexing agent and an antioxidant, the pH of the composition being in the range of about 5.8 to about 7.2.

Abstract translation: 一种水性磨料增白组合物，其含有化学和物理稳定的过氧化物增白化合物，其表现出增加和快速增白的牙齿和污渍去除，其包括水，磨料和过氧化物的组合，含有聚乙二醇的湿润剂，聚氧乙烯 - 聚氧丙烯 嵌段共聚物，金属离子络合剂和抗氧化剂，组合物的pH在约5.8至约7.2的范围内。

公开(公告)号：US5843409A

公开(公告)日：1998-12-01

申请号：US287371

申请日：1994-08-08

Applicant: Shannon K. Campbell ,  Edward Albert Tavss ,  Steven W. Fisher ,  Marilou Joziak ,  Richard F. Theiler ,  Michael Prencipe

Inventor： Shannon K. Campbell ,  Edward Albert Tavss ,  Steven W. Fisher ,  Marilou Joziak ,  Richard F. Theiler ,  Michael Prencipe

IPC: A61K20060101 ,  A61K8/19 ,  A61K8/21 ,  A61K8/34 ,  A61Q11/00 ,  B65D35/22 ,  A61K7/16 ,  A61K7/18

CPC classification number: A61K8/19 ,  A61K8/21 ,  A61K8/347 ,  A61Q11/00 ,  A61K2800/88

Abstract: A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing a desensitizing potassium salt such as potassium nitrate and a second dentifrice component containing a second desensitizing agent other than a potassium salt the such as SnF.sub.2, the second desensitizing agent being incompatible with the potassium salt, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth requiring relief from dentine hypersensitivity.

Abstract translation: 公开了一种双组分脱敏洁牙剂组合物，其包含含有脱敏钾盐如硝酸钾的第一洁牙剂组分和含有除SnF 2以外的钾盐的第二脱敏剂的第二洁齿剂组分，所述第二脱敏剂与 钾盐，第一和第二洁齿剂组分彼此分开，直到分配用于施用于需要缓解牙质超敏反应的牙齿。

公开(公告)号：US5292502A

公开(公告)日：1994-03-08

申请号：US908104

申请日：1992-07-02

Applicant: Michael R. Burke ,  Michael Prencipe ,  James M. Buchanan

Inventor： Michael R. Burke ,  Michael Prencipe ,  James M. Buchanan

IPC: A61K8/00 ,  A61K20060101 ,  A61K6/00 ,  A61K8/20 ,  A61K8/23 ,  A61K8/34 ,  A61K8/37 ,  A61K8/40 ,  A61K8/46 ,  A61K8/49 ,  A61K8/86 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/22

CPC classification number: A61Q11/00 ,  A61K8/347 ,  A61K8/466 ,  A61K8/4946

Abstract: An oral composition of acceptable taste substantially non-irritating to oral tissue, the composition containing an effective amount of a sodium lauryl sulfoacetate surfactant purified to contain less than 18% by weight impurities. An amount of a nonionic or amphoteric compound is included in the composition to enhance the foaming ability of the purified sodium lauryl sulfoacetate surfactant as well as to further reduce its irritancy potential.

Abstract translation: 口服组合物，其口服组合物对口腔组织基本上无刺激性，该组合物含有有效量的月桂基磺基乙酸钠表面活性剂，纯化至含有少于18重量％的杂质。 在组合物中含有一定量的非离子或两性化合物，以提高纯化的月桂基磺基乙酸钠表面活性剂的发泡能力，并进一步降低其刺激性。

公开(公告)号：US5279816A

公开(公告)日：1994-01-18

申请号：US796160

申请日：1991-11-22

Applicant: John A. Church ,  Michael Prencipe ,  Menachem Lewin

Inventor： John A. Church ,  Michael Prencipe ,  Menachem Lewin

IPC: A61K8/00 ,  A61C20060101 ,  A61K20060101 ,  A61K6/00 ,  A61K8/22 ,  A61K8/38 ,  A61K8/40 ,  A61K8/42 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC classification number: A61K8/38 ,  A61Q11/00

Abstract: An oral composition effective in whitening teeth comprising an amount of peroxyacetic acid effective to effect improved whitening of teeth.

Abstract translation: 一种有效美白牙齿的口服组合物，其含有一定量的过氧乙酸，其有效地改善牙齿美白。

公开(公告)号：US5256402A

公开(公告)日：1993-10-26

申请号：US759244

申请日：1991-09-13

Applicant: Michael Prencipe ,  Vincent Drago

Inventor： Michael Prencipe ,  Vincent Drago

IPC: A61K20060101 ,  A61K8/22 ,  A61K8/24 ,  A61K33/40 ,  A61Q11/00 ,  A61K7/20

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/24

Abstract: Abrasive dentifrice compositions containing an oxygen liberating whitening compound which is stable with respect to oxygen level and exhibits heightened and rapid whitening of teeth and stain removal which comprises a combination of a dicalcium phosphate compound and a metal ion free peroxide compound.

Abstract translation: 含有释氧美白化合物的研磨牙齿组合物，其对于氧水平是稳定的，并且表现出高度和快速的牙齿增白和去污，其包括磷酸二钙化合物和不含金属离子的过氧化物化合物的组合。

公开(公告)号：US10278796B2

公开(公告)日：2019-05-07

申请号：US14356810

申请日：2011-11-15

Applicant: Elva Chen ,  Sharon Kennedy ,  Yelloji-Rao Mirajkar ,  Suzanne Jogun ,  Michael Prencipe

Inventor： Elva Chen ,  Sharon Kennedy ,  Yelloji-Rao Mirajkar ,  Suzanne Jogun ,  Michael Prencipe

IPC: A61C19/06 ,  A61K8/73 ,  A61K8/04 ,  A61Q11/00 ,  A46B11/00 ,  A61C17/02 ,  A61K49/00

Abstract: The invention provides an oral care system comprising a gel in a pen dispenser, the dispenser comprising a chamber which permits dispensing of a measured amount of the gel, wherein the gel exhibits a Herschel-Bulkley yield stress of 10 to 230 dynes/cm2, a Herschel-Bulkley viscosity of 3 to 500 poise, and a Herschel-Bulkley rate index of 0.4 to 0.6, the specific viscosity permitting efficient application of the gel, as well as methods of using the same.

公开(公告)号：US09744112B2

公开(公告)日：2017-08-29

申请号：US14365116

申请日：2011-12-16

Applicant: Gregory Szewczyk ,  Neeta Atul Patel ,  Suzanne Jogun ,  Michael Prencipe

Inventor： Gregory Szewczyk ,  Neeta Atul Patel ,  Suzanne Jogun ,  Michael Prencipe

IPC: A61Q11/00 ,  A61K8/00 ,  A61K8/34 ,  A61K8/49 ,  A61K8/58 ,  A61K8/73 ,  A61K8/02

CPC classification number: A61K8/58 ,  A61K8/02 ,  A61K8/0216 ,  A61K8/494 ,  A61K8/731 ,  A61K2800/43 ,  A61K2800/58 ,  A61Q11/00

Abstract: Described herein are compositions comprising a film, wherein the film comprises a pigment, and is adapted to release the pigment at a specific point in time during use; and methods of making and using the same.