公开(公告)号：US20100004242A1

公开(公告)日：2010-01-07

申请号：US12089297

申请日：2006-10-05

Applicant: Asok Nath ,  Hiten Sharadchandra Mehta ,  Mohan Prasad

Inventor： Asok Nath ,  Hiten Sharadchandra Mehta ,  Mohan Prasad

IPC: A61K31/5377 ,  C07D265/32 ,  C07D413/06

CPC classification number: C07D265/32 ,  C07D413/06

Abstract: The present invention relates to a highly pure (2R,3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate of Formula II, and a process for its preparation. The present invention further provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof, using the highly pure compound of Formula II. The present invention also provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof which comprises of cyclising the compound of Formula VII at elevated temperature, in the absence of solvent.

Abstract translation: 本发明涉及式II的高纯度（2R，3S）-4-苄基-3-（4-氟苯基）吗啉-2-基3,5-双（三氟甲基）苯甲酸酯及其制备方法。 本发明还提供使用高度纯的式II化合物制备式I的阿维地丁或其药学上可接受的盐的方法。 本发明还提供了制备式I的阿维地敏剂或其药学上可接受的盐的方法，其包括在不存在溶剂的情况下在高温下使式VII的化合物环化。

公开(公告)号：US20090203921A1

公开(公告)日：2009-08-13

申请号：US12370249

申请日：2009-02-12

Applicant: Ira Saxena ,  Asok Nath ,  Mohan Prasad

Inventor： Ira Saxena ,  Asok Nath ,  Mohan Prasad

IPC: C07D257/04 ,  C07C255/50

CPC classification number: C07C255/58 ,  C07C255/60 ,  C07D257/04

Abstract: The present invention relates to processes for the preparation of intermediates of valsartan.

Abstract translation: 本发明涉及制备缬沙坦中间体的方法。

公开(公告)号：US20090062549A1

公开(公告)日：2009-03-05

申请号：US11913351

申请日：2006-04-26

Applicant: Seema Kanwar ,  Killol Patel ,  Keshav Deo ,  Mohan Prasad

Inventor： Seema Kanwar ,  Killol Patel ,  Keshav Deo ,  Mohan Prasad

IPC: C07D277/82

CPC classification number: C07D277/82

Abstract: The present invention provides processes for the preparation of (−) pramipexole or an acid addition salt thereof of Formula I. The present invention further provides for the novel polymorphic Forms A and B of anhydrous pramipexole dihydrochloride.

Abstract translation: 本发明提供制备式I的（ - ）普拉克索或其酸加成盐的方法。本发明还提供了无水普拉克索二盐酸盐的新型多晶型物A和B。

公开(公告)号：US20080119654A1

公开(公告)日：2008-05-22

申请号：US11946193

申请日：2007-11-28

Applicant: Mahavir Singh KHANNA ,  Bakthavathsalan Vijayaraghavan ,  Mohan Prasad ,  Yatendra Kumar

Inventor： Mahavir Singh KHANNA ,  Bakthavathsalan Vijayaraghavan ,  Mohan Prasad ,  Yatendra Kumar

IPC: C07D401/12

CPC classification number: C07D401/12

Abstract: The invention relates to an amorphous form of the salts of the (-) enantiomer or (S)-enantiomer of omeprazole, i.e., esomeprazole. The invention also relates to processes for preparing amorphous esomeprazole salts and pharmaceutical compositions that include the amorphous esomeprazole salts.

Abstract translation: 本发明涉及奥美拉唑的（ - ）对映异构体或（S） - 对映体的盐的无定形形式，即艾美拉唑。 本发明还涉及制备无定形艾美拉唑盐的方法和包括无定形艾美拉唑盐的药物组合物。

公开(公告)号：US20060122233A1

公开(公告)日：2006-06-08

申请号：US10539681

申请日：2003-12-16

Applicant: Yatendra Kumar ,  Mohan Prasad ,  Neela Kumar

Inventor： Yatendra Kumar ,  Mohan Prasad ,  Neela Kumar

IPC: A61K31/4439 ,  C07D403/02

CPC classification number: C07D401/12

Abstract: The present invention relates to calcium salts of rabeprazole and processes for preparing rabeprazole calcium. The invention also relates to pharmaceutical compositions that include the rabeprazole calcium and use of said compositions for the treatment or prevention of gastrointestinal ulcers

Abstract translation: 本发明涉及雷贝拉唑的钙盐和雷贝拉唑钙的制备方法。 本发明还涉及包含雷贝拉唑钙的药物组合物和所述组合物用于治疗或预防胃肠溃疡的药物组合物

公开(公告)号：US20050080255A1

公开(公告)日：2005-04-14

申请号：US10498406

申请日：2002-12-12

Applicant: Yatendra Kumar ,  Mohan Prasad ,  Ashok Prasad ,  Shailendra Singh ,  Neela Kumar

Inventor： Yatendra Kumar ,  Mohan Prasad ,  Ashok Prasad ,  Shailendra Singh ,  Neela Kumar

IPC: A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/22 ,  C07D501/14

CPC classification number: C07D501/00

Abstract: The present invention relates to a novel crystalline cefdinir potassium dihydrate, to a process for its preparation and to a method of preparing pure cefdinir via the crystalline salt.

Abstract translation: 本发明涉及一种新的结晶头孢地尼钾二水合物，其制备方法和通过结晶盐制备纯头孢地尼的方法。

公开(公告)号：US08680298B2

公开(公告)日：2014-03-25

申请号：US12602947

申请日：2008-06-06

Applicant: Patil Dattatray Bapuso ,  Killol Patel ,  Ashok Prasad ,  Keshav Deo ,  Mohan Prasad

Inventor： Patil Dattatray Bapuso ,  Killol Patel ,  Ashok Prasad ,  Keshav Deo ,  Mohan Prasad

IPC: C07D305/12

CPC classification number: C07D305/12

Abstract: The present invention provides a process for preparing orlistat from amino orlistat using Pivaloyl Formic Anhydride (PFA) as an alkanoylating agent.

Abstract translation: 本发明提供了使用新戊酰甲酸酐（PFA）作为烷酰化剂从氨基索列司他制备奥利司他的方法。

公开(公告)号：US08618305B2

公开(公告)日：2013-12-31

申请号：US13575057

申请日：2011-01-28

Applicant: Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sachin Deorao Zade ,  Ajay Shankar Singh

Inventor： Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sachin Deorao Zade ,  Ajay Shankar Singh

IPC: A61K31/44 ,  C07D213/81

CPC classification number: C07D213/81 ,  G01N30/02

Abstract: The present invention provides dimethyl sulphoxide solvate of 4-(4-{3-[4-chloro-3 -(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide, process for its preparation, pharmaceutical composition comprising it and its use for the treatment of cancer. The present invention also provides a novel HPLC method for the identification, quantification and isolation of related substances of sorafenib.

Abstract translation: 本发明提供4-（4- {3- [4-氯-3-（三氟甲基）苯基]脲基}苯氧基）-N2-甲基吡啶-2-甲酰胺的二甲基亚砜溶剂合物，其制备方法，包含它的药物组合物 并用于治疗癌症。 本发明还提供了用于鉴定，定量和分离索拉非尼相关物质的新型HPLC方法。

公开(公告)号：US08552197B2

公开(公告)日：2013-10-08

申请号：US13508878

申请日：2010-11-12

Applicant: Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: A61K31/44 ,  C07D211/72

CPC classification number: C07D213/81

Abstract: The present invention provides sorafenib ethane sulphonate, process for its preparation, pharmaceutical composition comprising sorafenib ethane sulphonate and its use for the treatment of cancer. Formula (III).

Abstract translation: 本发明提供索拉非尼乙磺酸盐，其制备方法，包含索拉非尼乙磺酸盐的药物组合物及其用于治疗癌症的用途。 式（III）。

公开(公告)号：US20130245278A1

公开(公告)日：2013-09-19

申请号：US13812066

申请日：2011-07-15

Applicant: Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

Inventor： Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

Abstract translation: 提供了一种改进和有效的制备基本上不含酰胺副产物的2- [3-氰基-4-（2-甲基丙氧基）苯基] -4-甲基噻唑-5-羧酸（febustostat）的方法。