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公开(公告)号：US20150005331A1
公开(公告)日：2015-01-01
申请号：US14470631
申请日：2014-08-27
IPC分类号： A61K47/10 , A61K47/38 , A61K47/26 , A61K31/485
CPC分类号： A61K9/2054 , A61J3/10 , A61K8/731 , A61K9/0002 , A61K9/0053 , A61K9/006 , A61K9/0095 , A61K9/06 , A61K9/08 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2095 , A61K9/28 , A61K9/2806 , A61K9/2813 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K9/48 , A61K9/4808 , A61K9/4833 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K9/4891 , A61K9/5047 , A61K9/5078 , A61K9/5089 , A61K9/70 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/439 , A61K31/4458 , A61K31/48 , A61K31/485 , A61K45/06 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38
摘要： Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
摘要翻译： 在某些实施方案中公开了一种控释口服剂型，其包含治疗有效量的易于与一种或多种药学上可接受的赋形剂一起滥用的药物; 所述剂型还包括有效量的胶凝剂，以使得不适于施用的粘度，所述粘度选自肠胃外和鼻内施用于当所述剂型粉碎时形成的溶解混合物，并与约0.5至约10ml 的水性液体; 所述剂型在口服施用于人类患者时提供至少约12小时的治疗效果。
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公开(公告)号：US11826472B2
公开(公告)日：2023-11-28
申请号：US18143927
申请日：2023-05-05
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00 , B29K71/00 , B29K105/00 , B29L31/00
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/209 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , A61K9/2072 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20210000747A1
公开(公告)日：2021-01-07
申请号：US17027088
申请日：2020-09-21
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20200062772A1
公开(公告)日：2020-02-27
申请号：US16557937
申请日：2019-08-30
申请人： Purdue Pharma L.P. , The P.F. Laboratories, Inc. , Purdue Pharmaceuticals L.P. , Rhodes Technologies
发明人： Robert CHAPMAN , Lonn S. RIDER , Qi HONG , Donald KYLE , Robert KUPPER
IPC分类号： C07D489/08 , C07D489/04 , A61K9/48 , A61K9/20 , A61K9/14 , A61K31/485 , C07D489/02
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
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公开(公告)号：US10206881B2
公开(公告)日：2019-02-19
申请号：US15803370
申请日：2017-11-03
IPC分类号： A61J3/10 , A61K9/20 , A61K9/00 , A61K31/439 , A61K31/485 , A61K47/38 , A61K47/36 , A61K47/10 , A61K45/06 , A61K31/167 , A61K31/192 , A61K9/16 , A61K47/26 , A61K31/48 , A61K9/48 , A61K47/08 , A61K9/50 , A61K47/32 , A61K9/08 , A61K9/28 , A61K47/12 , A61K47/34 , A61K9/06 , A61K31/4458 , A61K31/137 , A61K47/14 , A61K9/70 , A61K47/02 , A61K9/19 , A61K8/73 , A61K47/20
摘要： Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
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公开(公告)号：US10076498B2
公开(公告)日：2018-09-18
申请号：US15885254
申请日：2018-01-31
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61K31/485 , A61K47/34 , A61K45/06 , A61K47/10 , A61J3/06 , A61K9/00 , A61K9/24 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00 , B29K71/00 , B29K105/00 , B29L31/00
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20180153814A1
公开(公告)日：2018-06-07
申请号：US15885254
申请日：2018-01-31
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , B29C43/52 , A61J3/00 , B29C43/00 , A61J3/10 , A61K47/10 , A61K47/34 , A61K31/485 , A61K9/00 , A61J3/06 , A61K45/06 , A61K9/24
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20170319498A1
公开(公告)日：2017-11-09
申请号：US15657916
申请日：2017-07-24
IPC分类号： A61K9/28 , A61J3/06 , A61J3/00 , B29C43/00 , B29C37/00 , A61K47/34 , A61K47/10 , A61K45/06 , A61K31/485 , A61K9/20 , A61K9/24 , A61K9/16 , A61K9/00 , A61J3/10 , B29C43/52 , B29K71/00
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20170319496A1
公开(公告)日：2017-11-09
申请号：US15657852
申请日：2017-07-24
IPC分类号： A61K9/28 , A61J3/06 , A61J3/00 , B29C43/00 , B29C37/00 , A61K47/34 , A61K47/10 , A61K45/06 , A61K31/485 , A61K9/20 , A61K9/24 , A61K9/16 , A61K9/00 , A61J3/10 , B29C43/52 , B29K71/00
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US09775811B2
公开(公告)日：2017-10-03
申请号：US15413554
申请日：2017-01-24
IPC分类号： A61K9/20 , A61K9/28 , A61K31/485 , A61K9/00 , B29C37/00 , B29B7/02 , B29C43/00 , B29C43/02 , B29C43/52 , B29C71/00 , B29B7/88 , B29C35/16 , B29K71/00 , B29L31/00 , B29K105/00
CPC分类号： A61K9/28 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0002 , A61K9/0053 , A61K9/1641 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K31/485 , A61K45/06 , A61K47/10 , A61K47/34 , B29B7/02 , B29B7/88 , B29C35/045 , B29C35/16 , B29C37/0025 , B29C43/003 , B29C43/02 , B29C43/52 , B29C71/00 , B29C71/009 , B29C2035/046 , B29C2035/1658 , B29K2071/02 , B29K2105/0035 , B29K2105/251 , B29K2995/0088 , B29L2031/753
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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