公开(公告)号：US20170015999A1

公开(公告)日：2017-01-19

申请号：US15284693

申请日：2016-10-04

Applicant: Rosetta Genomics Ltd.

Inventor： Noga Yerushalmi

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/30 ,  C12N2320/31

Abstract: The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to different miRNAs for treating different types of ovarian cancers in a subject. Furthermore, different modifications of miRNA inhibitor molecules as well as different derivatives of miRNA inhibitor molecules are also described.

Abstract translation: 本公开提供了用于治疗受试者的卵巢癌的组合物和方法。 更具体地，本公开提供了靶向不同miRNA的微小RNA（miRNA）抑制剂分子，用于治疗受试者中不同类型的卵巢癌。 此外，还描述了miRNA抑制剂分子的不同修饰以及miRNA抑制剂分子的不同衍生物。

公开(公告)号：US09506062B2

公开(公告)日：2016-11-29

申请号：US14833889

申请日：2015-08-24

Applicant: Regulus Therapeutics Inc. ,  Rosetta Genomics Ltd.

Inventor： C. Frank Bennett ,  Ayelet Chajut ,  Christine Esau ,  Eric Marcusson ,  Noga Yerushalmi

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/7088 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K31/7088 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.

公开(公告)号：US09487781B2

公开(公告)日：2016-11-08

申请号：US14505548

申请日：2014-10-03

Applicant: Rosetta Genomics Ltd.

Inventor： Noga Yerushalmi

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7088 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/30 ,  C12N2320/31

Abstract: The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to different miRNAs for treating different types of ovarian cancers in a subject. Furthermore, different modifications of miRNA inhibitor molecules as well as different derivatives of miRNA inhibitor molecules are also described.

Abstract translation: 本公开提供了用于治疗受试者的卵巢癌的组合物和方法。 更具体地，本公开提供了针对不同miRNA的微小RNA（miRNA）抑制剂分子，用于治疗受试者中不同类型的卵巢癌。 此外，还描述了miRNA抑制剂分子的不同修饰以及miRNA抑制剂分子的不同衍生物。

公开(公告)号：US20160319363A1

公开(公告)日：2016-11-03

申请号：US14999879

申请日：2016-07-13

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

Abstract translation: 本文描述了与前列腺和肺癌相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

公开(公告)号：US20160046935A1

公开(公告)日：2016-02-18

申请号：US14756185

申请日：2015-08-13

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

Abstract translation: 本文描述了与前列腺和肺癌相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

公开(公告)号：US20160002639A1

公开(公告)日：2016-01-07

申请号：US14796112

申请日：2015-07-10

Applicant: Rosetta Genomics Ltd.

Inventor： Issac Bentwich ,  Amir Avniel ,  Ranit Aharonov ,  Yael Karov ,  Yonat Shemer-Avni ,  Asaf Levy

IPC: C12N15/113

CPC classification number: C12N15/1133 ,  A61K48/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2330/31 ,  C12N2710/16022 ,  C12N2760/16122 ,  C12N2760/18522

Abstract: The invention provides isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids are useful for prevention, treatment and diagnosis of viral infections.

Abstract translation: 本发明提供了与病毒感染相关的分离的病毒和人核酸以及与之相关的或从其衍生的各种核酸分子。 核酸可用于病毒感染的预防，治疗和诊断。

公开(公告)号：US20150099665A1

公开(公告)日：2015-04-09

申请号：US14572276

申请日：2014-12-16

Applicant: ROSETTA GENOMICS LTD. ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Nitzan Rosenfeld ,  Shai Rosenwald ,  Iris Barshack ,  Gila Lithwick Yanai

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y10T436/143333

Abstract: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers.

Abstract translation: 本发明提供了用于肺癌鉴定，分类和诊断的核酸序列。 本发明进一步提供与特定类型的肺癌相关的微小RNA分子，以及与之相关的或由其衍生的各种核酸分子。

公开(公告)号：US20150031751A1

公开(公告)日：2015-01-29

申请号：US14505548

申请日：2014-10-03

Applicant: ROSETTA GENOMICS LTD.

Inventor： Noga YERUSHALMI

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/30 ,  C12N2320/31

Abstract: The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to different miRNAs for treating different types of ovarian cancers in a subject. Furthermore, different modifications of miRNA inhibitor molecules as well as different derivatives of miRNA inhibitor molecules are also described.

Abstract translation: 本公开提供了用于治疗受试者的卵巢癌的组合物和方法。 更具体地，本公开提供了靶向不同miRNA的微小RNA（miRNA）抑制剂分子，用于治疗受试者中不同类型的卵巢癌。 此外，还描述了miRNA抑制剂分子的不同修饰以及miRNA抑制剂分子的不同衍生物。