公开(公告)号：US20190010491A1

公开(公告)日：2019-01-10

申请号：US15732957

申请日：2018-01-16

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/6886

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods ad compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US20170240894A1

公开(公告)日：2017-08-24

申请号：US15586783

申请日：2017-05-04

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US20170226510A1

公开(公告)日：2017-08-10

申请号：US15731118

申请日：2017-04-21

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US20140179757A1

公开(公告)日：2014-06-26

申请号：US13986802

申请日：2013-06-06

Applicant: ROSETTA GENOMICS, LTD.

Inventor： Issac Bentwich ,  Amir Avniel ,  Ranit Aharonov ,  Yael Karov ,  Yonat Shemer-Avni ,  Asaf Levy

IPC: C12N15/113

CPC classification number: C12N15/1133 ,  A61K48/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2330/31 ,  C12N2710/16022 ,  C12N2760/16122 ,  C12N2760/18522

Abstract: Provided herein are isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids may be useful for the prevention, treatment and diagnosis of viral infections.

Abstract translation: 本文提供了与病毒感染相关的分离的病毒和人核酸以及与其相关或由其衍生的各种核酸分子。 核酸可用于预防，治疗和诊断病毒感染。

公开(公告)号：US09890382B2

公开(公告)日：2018-02-13

申请号：US15586783

申请日：2017-05-04

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/11 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US20160047004A1

公开(公告)日：2016-02-18

申请号：US14797381

申请日：2015-07-13

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12Q1/70 ,  C12N15/113

CPC classification number: C12Q1/701 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/30 ,  C12N2330/10 ,  C12N2710/16222 ,  C12Q2600/136

Abstract: Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.

Abstract translation: 本文描述的是与病毒感染相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定病毒感染调节剂的方法。

公开(公告)号：US20150368724A1

公开(公告)日：2015-12-24

申请号：US14746487

申请日：2015-06-22

Applicant: Rosetta Genomics Ltd.

Inventor： Ranit Aharonov ,  Nitzan Rosenfeld ,  Shai Rosenwald ,  Nir Dromi

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.

Abstract translation: 本发明通过分析与其有关的特异性微小RNA和核酸分子的表达模式，提供了对癌症和原始组织进行分类的方法。 根据基于microRNA树的表达框架进行分类可以优化治疗，并确定特异性治疗。

公开(公告)号：US20170298447A1

公开(公告)日：2017-10-19

申请号：US15586747

申请日：2017-05-04

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12Q1/68 ,  A61K38/00 ,  C12N15/11 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US09650680B2

公开(公告)日：2017-05-16

申请号：US14999879

申请日：2016-07-13

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/11 ,  C07H21/04 ,  C12Q1/68 ,  A61K38/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US09650679B2

公开(公告)日：2017-05-16

申请号：US14756185

申请日：2015-08-13

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C07H21/04 ,  C12N15/11 ,  C12Q1/68 ,  A61K38/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.