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公开(公告)号：US11076757B2
公开(公告)日：2021-08-03
申请号：US16068994
申请日：2017-01-12
Inventor： Ygal Rotenstreich , Ifat Sher
Abstract: A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye.
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公开(公告)号：US20210186478A1
公开(公告)日：2021-06-24
申请号：US17271189
申请日：2019-08-29
Inventor： Ari LESHNO
Abstract: Apparatus for performing an ocular surgery, the apparatus comprising: a support housing having a bottom configured to be positioned on the sclera of an eye during performance of an ocular surgery; a muscle hook holder connected to the support housing and configured to hold an ocular muscle hook so that the ocular muscle hook is translatable to elevate an ocular muscle away from the eye during performance of the surgery; and a set of graduation markings on the support housing useable to determine a distance that the ocular muscle hook is translated to elevate the ocular muscle.
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公开(公告)号：US20210163591A1
公开(公告)日：2021-06-03
申请号：US17263251
申请日：2019-07-25
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Tageza Biopharmaceuticals Ltd.
Inventor： Benjamin DEKEL , Orit HARARI-STEINBERG
IPC: C07K16/28 , G01N33/574 , A61K35/17 , C12Q1/6886 , A61K47/68
Abstract: Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GABRA2, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GABRA2. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.
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公开(公告)号：US20200345546A1
公开(公告)日：2020-11-05
申请号：US16935236
申请日：2020-07-22
Applicant: Ramot at Tel Aviv University Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Michael Belkin , Mordechai Goldenfeld
Abstract: Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.
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公开(公告)号：US10719921B2
公开(公告)日：2020-07-21
申请号：US16097285
申请日：2017-05-04
Applicant: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Arnaldo Mayer , Michael Green , Nahum Kiryati , Edith M. Marom , Eli Konen
Abstract: A method of providing a medical image of a ROI of a patient, the method comprising: acquiring a first medical image of a region of interest (ROI) of a patient, the medical image characterized by a first signal to noise ratio (SNR); determining for a given pixel in the first image a plurality of different first image patches in the first image, each having a pixel that is coincident with the given pixel; determining for each first image patch a similar second image patch having a second SNR greater than the first SNR; determining an enhanced pixel value for the given pixel having an enhanced SNR greater than the first SNR responsive to pixel values of pixels in the determined second image patches; and using the determined pixel value to generate a second medical image of the ROI having an enhanced SNR greater than the first SNR.
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Patent Agency Ranking
公开(公告)号：US20200095293A1
公开(公告)日：2020-03-26
申请号：US16704849
申请日：2019-12-05
Inventor： Amir ZLOTKIN
IPC: C07K14/435 , C07K7/06 , C07K7/08 , C02F1/50 , C02F1/44
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence consisting of SVHSFDYDWYNV, or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
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公开(公告)号：US20200062808A1
公开(公告)日：2020-02-27
申请号：US16680366
申请日：2019-11-11
Inventor： Amir ZLOTKIN
IPC: C07K14/435 , C02F1/50 , C02F1/44 , C07K7/08 , C07K7/06
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
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公开(公告)号：US20200061355A1
公开(公告)日：2020-02-27
申请号：US16461383
申请日：2017-11-16
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Ofer BARNEA , Omer DORON
Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
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公开(公告)号：US10568901B2
公开(公告)日：2020-02-25
申请号：US15744086
申请日：2016-07-14
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Avital Gilam , Noam Shomron , Eitan Friedman
IPC: A61K31/7105 , C12N15/113 , A61K31/713 , A61P35/04
Abstract: Provided are compositions and methods for treating cancer, particularly solid tumors, and cancer metastasis, using micro-RNAs mi R-96 and/or mi R-182.
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公开(公告)号：US20190321020A1
公开(公告)日：2019-10-24
申请号：US16408506
申请日：2019-05-10
Inventor： Leonid STERNIK
IPC: A61B17/00 , A61B17/30 , A61B17/12 , A61B17/221 , A61B17/08 , A61B17/064
Abstract: A device for manipulating the left atrial appendage (LAA) of a heart, including: an elongated and hollow guide instrument which is shaped and sized to be transvascularly and transseptally introducible into the left atrium (LA); a suction channel passing through the guide instrument, the suction channel terminating with a concave holder, wherein the suction channel and the concave holder are shaped and sized to be enclosed within a lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of the guide instrument after reaching the LA, and wherein the concave holder is configured to radially expand; a loop fastener shaped and sized to be enclosed within the lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of said guide instrument.
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