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公开(公告)号:US20230360220A1
公开(公告)日:2023-11-09
申请号:US18223106
申请日:2023-07-18
申请人: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd.
CPC分类号: G06T7/0016 , A61B5/026 , A61B3/11 , G06T2207/10024 , G06T2207/20081 , G06T2207/30041 , G06T2207/30104
摘要: A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).
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公开(公告)号:US11779459B2
公开(公告)日:2023-10-10
申请号:US17349152
申请日:2021-06-16
发明人: Ehud Raanani , Boris Orlov , Boaz Harari , Oded Meiri , Lichen Rozitsky
IPC分类号: A61F2/24
CPC分类号: A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2457 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0013 , A61F2230/0078 , A61F2250/006
摘要: Apparatus and methods are described including a valve frame defining a frame aperture and at least one arm attached to a portion of the valve frame on a ventricular side of said frame aperture. The at least one arm is configured to extend radially from the portion of the valve frame such that a chord receiving surface of the arm is sized and shaped to deploy among a region of the chords of the native mitral valve. The arm is curved, with an interior of the arm facing a direction in which the valve frame is configured to be rotated during deployment of the prosthetic mitral valve apparatus within the native mitral valve and with the arm having a concavely rounded leading edge facing at least partially in a circumferential direction. Other applications are also described.
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公开(公告)号:US11699236B2
公开(公告)日:2023-07-11
申请号:US17487082
申请日:2021-09-28
申请人: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd.
发明人: Yitzhak Avital , Nahum Kiryati , Eli Konen , Arnaldo Mayer
CPC分类号: G06T7/11 , A61B5/0042 , A61B5/055 , A61B5/4381 , A61B5/7267 , A61B34/20 , A61B34/32 , G01R33/5602 , G01R33/5608 , G06N3/08 , G06T2200/04 , G06T2207/10092 , G06T2207/20081 , G06T2207/20084 , G06T2207/20132 , G06T2207/20156 , G06T2207/30016 , G06T2207/30081 , G06T2207/30096
摘要: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).
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公开(公告)号:US11565091B2
公开(公告)日:2023-01-31
申请号:US16461383
申请日:2017-11-16
申请人: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd. , Hadasit Medical Research Services and Development Ltd.
发明人: Ofer Barnea , Omer Doron
IPC分类号: A61M27/00 , A61M25/10 , A61M25/00 , A61B5/03 , A61M60/122 , A61M60/268
摘要: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
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公开(公告)号:US11534126B2
公开(公告)日:2022-12-27
申请号:US17163934
申请日:2021-02-01
IPC分类号: G06T7/00 , G06T7/11 , G06T7/13 , A61B6/04 , A61B6/00 , G06V10/46 , G06V10/44 , G06V10/50 , G06V10/42 , G06T7/44 , A61B6/12
摘要: Apparatus for diagnosing breast cancer, the apparatus comprising a controller having a set of instructions executable to: acquire a contrast enhanced region of interest (CE-ROI) in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; determine a texture neighborhood for each of a plurality of X-ray pixels in the CE-ROI, the texture neighborhood for a given X-ray pixel of the plurality of X-ray pixels extending to a bounding pixel radius of BPR pixels from the given pixel; generate a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI that are located within the texture neighborhood; and use a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.
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公开(公告)号:US20220362021A1
公开(公告)日:2022-11-17
申请号:US17624437
申请日:2020-07-03
IPC分类号: A61F2/24
摘要: Apparatus for coupling a prosthetic chorda to an atrioventricular valve leaflet, the apparatus comprising: a neochorda delivery system comprising a steerable and pushable catheter housing a neochorda attached to a neochorda puncture needle, the catheter operable to push the puncture needle to puncture and thread the neochorda through a papillary muscle of a ventricle; a retriever system comprising a catheter housing a grabber operable to capture the neochorda puncture needle after being threaded through the papillary muscle and withdraw the neochorda puncture needle and neochorda from the ventricle; and a tissue clamping system comprising a catheter housing distal and proximal tissue clamps deployable to clamp a region of an atrioventricular valve between them and hold the region so that it may be punctured by the puncture needle to deliver the neochorda through the leaflet and to the papillary muscle.
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公开(公告)号:US20220146311A1
公开(公告)日:2022-05-12
申请号:US17582741
申请日:2022-01-24
摘要: A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.
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公开(公告)号:US11266389B2
公开(公告)日:2022-03-08
申请号:US16408506
申请日:2019-05-10
发明人: Leonid Sternik
IPC分类号: A61B17/00 , A61B17/12 , A61B17/30 , A61B17/064 , A61B17/08 , A61B17/221
摘要: A device for manipulating the left atrial appendage (LAA) of a heart, including: an elongated and hollow guide instrument which is shaped and sized to be transvascularly and transseptally introducible into the left atrium (LA); a suction channel passing through the guide instrument, the suction channel terminating with a concave holder, wherein the suction channel and the concave holder are shaped and sized to be enclosed within a lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of the guide instrument after reaching the LA, and wherein the concave holder is configured to radially expand; a loop fastener shaped and sized to be enclosed within the lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of said guide instrument.
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公开(公告)号:US11261230B2
公开(公告)日:2022-03-01
申请号:US16914388
申请日:2020-06-28
申请人: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
发明人: Genady Kostenich , Mor Oron-Herman , Arie Orenstein , Talia Shekhter Zahavi , Ehud Gazit , Yoseph Salitra , Ludmila Buzhansky
摘要: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号:US11170508B2
公开(公告)日:2021-11-09
申请号:US16959693
申请日:2019-01-03
申请人: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd.
发明人: Yitzhak Avital , Nahum Kiryati , Eli Konen , Arnaldo Mayer
摘要: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).
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