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公开(公告)号：US06265536B1
公开(公告)日：2001-07-24
申请号：US09248267
申请日：1999-02-11
IPC分类号： A61K3800
摘要： This invention relates to new polypeptide compounds represented by the following formula (I): wherein R1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译： 本发明涉及由下式（I）表示的新的多肽化合物：其中R1如描述中所定义，其药学上可接受的盐具有抗微生物活性（特别是抗真菌活性），对β-1,3-葡聚糖合酶的抑制活性 ，其制备方法，包含其的药物组合物，以及用于预防和/或治疗人或动物中包括卡氏肺囊虫感染（例如肺孢子虫肺炎）的感染性疾病的方法。
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公开(公告)号：US06248533B1
公开(公告)日：2001-06-19
申请号：US09448176
申请日：1999-11-24
申请人： Shintaro Kamizono , Akira Yamada , Takafumi Higuchi , Hirohisa Kato , Kyogo Itoh , Naoko Seki
发明人： Shintaro Kamizono , Akira Yamada , Takafumi Higuchi , Hirohisa Kato , Kyogo Itoh , Naoko Seki
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method of gene diagnosis of diseases wherein TNF-&agr; promoters participate, such as juvenile rheumatoid arthritis, chronic rheumatism or diabetes, by determining in the nucleotides at the −857, −863 and/or −1031 positions in the 5′-flanking region of a TNF-&agr; gene.
摘要翻译： 通过在5'-侧翼区域-857，-863和/或-1031位置的核苷酸中测定TNF-α启动子参与的疾病的基因诊断方法，例如少年类风湿性关节炎，慢性风湿病或糖尿病 的TNF-α基因。
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公开(公告)号：US6123540A
公开(公告)日：2000-09-26
申请号：US869248
申请日：1997-06-04
申请人： Kan Ogata , Akira Yamada , Kimishiro Tokuda , Toshimitsu Ichinose , Hiroshi Kikuchi , Yasuo Souda , Satoshi Uchida , Syozo Kaneko
发明人： Kan Ogata , Akira Yamada , Kimishiro Tokuda , Toshimitsu Ichinose , Hiroshi Kikuchi , Yasuo Souda , Satoshi Uchida , Syozo Kaneko
摘要： A heavy oil emulsion fuel combustion apparatus is arranged, in a combustion apparatus using a heavy oil emulsion fuel, to prevent a decrease in the combustion efficiency due to water content in the fuel and to prevent an increase in the sulfuric acid dew point due to water content in the exhaust gas. A heavy oil emulsion fuel 101 from a fuel tank 100 is led to a fuel heater 110 and is heated. Then the heated heavy oil emulsion fuel 102 is led to a water content evaporator 120. In the water content evaporator 120, the heavy oil emulsion fuel 102 is heated by the use of extraction steam from a steam turbine facility 160 or steam produced through a steam converter 166, and the resulting fuel is led to a steam separator 140. In the steam separator 140, the fuel 111 is separated into steam and light oil combustible gas vapor 121 and a heavy oil portion 122, the latter 122 being used as boiler fuel 131. The steam and light oil combustible gas vapor 121 is used as a heat source for heating performed in the fuel heater 110.
摘要翻译： 在使用重油乳化燃料的燃烧装置中设置重油乳化燃料燃烧装置，以防止燃料中的水分含量引起的燃烧效率降低，并防止由于水引起的硫酸露点的增加 废气中的含量。 来自燃料箱100的重油乳化燃料101被引导到燃料加热器110并被加热。 然后将加热的重油乳化燃料102引导到含水蒸发器120.在含水蒸发器120中，重油乳化燃料102通过使用来自蒸汽轮机设备160的提取蒸汽或通过蒸汽产生的蒸汽来加热 转化器166，并且所得到的燃料被引导到蒸汽分离器140.在蒸气分离器140中，燃料111被分离成蒸汽和轻油可燃气体蒸气121和重油部分122，后者122用作锅炉燃料 蒸汽和轻油可燃气体蒸气121用作在燃料加热器110中进行加热的热源。
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公开(公告)号：US6107458A
公开(公告)日：2000-08-22
申请号：US809723
申请日：1997-05-21
IPC分类号： A61K38/00 , A61K31/395 , A61P31/04 , A61P31/10 , C07D487/14 , C07K1/02 , C07K7/56 , A61K38/12 , C07K5/00 , C07K7/00
摘要： This invention relates to new polypeptide compounds represented by the following formula (I): ##STR1## wherein R.sup.1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on .beta.-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译： PCT No.PCT / JP95 / 01983 Sec。 371日期1997年5月21日 102（e）日期1997年5月21日PCT提交1995年9月29日PCT公布。 公开号WO96 / 11210 PCT 日本本发明涉及由下式（I）表示的新的多肽化合物：其中R1如描述中所定义，其药学上可接受的盐具有抗微生物活性（特别是抗真菌活性），对β- 1,3-葡聚糖合酶，其制备方法，含有该组合物的药物组合物，以及用于预防和/或治疗感染性疾病的方法，包括人类卡氏肺囊虫感染（例如肺孢子虫卡氏肺炎） 或动物。
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公开(公告)号：US6053089A
公开(公告)日：2000-04-25
申请号：US136593
申请日：1998-08-19
CPC分类号： B60T13/163
摘要： In this invention, an idea is adopted in which the pressure at a forward portion and a backward portion of valve device is steppingly dropped twice. The valve device of the present invention includes, on the axis of a spool 600, a first valve 710 located nearer an inlet port and a second valve 720 located nearer an outlet port. A throttling area made by the second valve 720 is larger than a throttling area made by the first valve 710. For example, of all the pressure difference equal to 120 kg/cm.sup.2 or more required at the forward and backward portions of the valve device, a portion in the range where the problem of an occurrence of a foreign noise is not encountered (for example, a portion ranging from 100 to 120 kg/cm.sup.2) is undertaken by the first valve 710, and the remaining portion ranging from 20 to 30 kg/cm.sup.2 is undertaken by the second valve 720. By doing so, there can be eliminated such a pressure difference where a generation of a noise before and after an actual throttling (including a primary throttling made by the first valve 710 and a secondary throttling made by the second valve 720) can become a problem.
摘要翻译： 在本发明中，采用将阀装置的前部和后部的压力逐步下降两次的思路。 本发明的阀装置在阀芯600的轴线上包括位于更靠近出口端口的入口端口和第二阀门720附近的第一阀门710。 由第二阀720制造的节流区域大于由第一阀710制成的节流区域。例如，在阀装置的前后部分所需的所有压力差等于120kg / cm 2以上， 在第一阀710进行没有遇到异物发生的问题的范围（例如，100〜120kg / cm 2的范围）的部分，其余部分为20〜30 kg / cm 2由第二阀720进行。通过这样做，可以消除在实际节流前后产生噪声（包括由第一阀710产生的主节流和二次节流） 由第二阀720制造）可能成为问题。
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公开(公告)号：US5913079A
公开(公告)日：1999-06-15
申请号：US689045
申请日：1996-07-30
申请人： Keisuke Aoyama , Akira Yamada , Akira Akashi
发明人： Keisuke Aoyama , Akira Yamada , Akira Akashi
CPC分类号： G02B27/0093 , G02B7/28 , G02B7/287 , G03B13/02 , G03B2213/025
摘要： An apparatus having a line of sight detection device, comprises a viewfinder for observing a target object, a line of sight detection means for detecting a position of line of sight in the viewfinder of a user, focus detection means being possible to select a first operation mode for performing a first focus detecting operation or a second operation mode for performing a second focus detecting operation, and being possible to perform a focus detection to each of a plurality of focus detecting areas arranged in the viewfinder, range setting means for setting a plurality of determination range including the focus detecting areas, and for changing a size of the determination range to be set in accordance with the selection of the operation mode of the focus detecting means, selecting means for determining which determination range includes the position of line of sight detected by the line of sight detecting means, and for selecting at least one focus detecting area among the plurality of focus detecting areas, and focus adjusting means for adjusting a focus of an optical system based on a focus detecting result of the selected focus detecting area.
摘要翻译： 一种具有视线检测装置的装置，包括用于观察目标物体的取景器，用于检测用户取景器中的视线位置的视线检测装置，焦点检测装置可以选择第一操作 用于执行第一焦点检测操作的模式或用于执行第二焦点检测操作的第二操作模式，并且可以对布置在取景器中的多个焦点检测区域中的每一个执行焦点检测，范围设置装置用于设置多个 包括焦点检测区域的确定范围，以及用于根据焦点检测装置的操作模式的选择来改变要设置的确定范围的大小的选择装置，用于确定哪个确定范围包括视线位置 由视线检测装置检测，并且用于选择多个中的至少一个焦点检测区域 焦点检测区域，以及聚焦调整装置，用于基于所选焦点检测区域的焦点检测结果来调整光学系统的焦点。
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公开(公告)号：US5579079A
公开(公告)日：1996-11-26
申请号：US425082
申请日：1995-04-19
申请人： Akira Yamada , Keiji Nagata , Yoshiaki Irie , Akihiko Nagano
发明人： Akira Yamada , Keiji Nagata , Yoshiaki Irie , Akihiko Nagano
CPC分类号： G02B7/28 , G02B27/0093 , G02B7/287 , G03B13/02 , G03B2213/025
摘要： An apparatus for detecting information of an eye of a person includes a light illuminating unit for illuminating the eye of the person with light from a plurality of different positions, a photoelectrical changing device for detecting light reflected from the eye, and a controlling device for controlling the light illuminating unit in accordance with whether or not the person is wearing spectacles.
摘要翻译： 一种用于检测人眼的信息的装置包括：用于利用来自多个不同位置的光照射人的眼睛的光照射单元，用于检测从眼睛反射的光的光电变换装置，以及用于控制眼睛的控制装置 照明单元根据人是否戴眼镜。
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58.发明授权Accumulation control apparatus for photoelectric conversion element and visual axis detection apparatus using the element 失效用于光电转换元件的累积控制装置和使用该元件的视轴检测装置
公开(公告)号：US5541400A
公开(公告)日：1996-07-30
申请号：US142062
申请日：1993-10-28
申请人： Shinichi Hagiwara , Akira Yamada , Yoshiaki Irie
发明人： Shinichi Hagiwara , Akira Yamada , Yoshiaki Irie
CPC分类号： G02B7/287 , G03B13/02 , H04N5/23293 , G03B2213/025
摘要： An apparatus includes a photoelectric conversion device having a plurality of photoelectric conversion elements for converting light to photoelectric conversion signals and for transferring the photoelectric conversion signals to adjacent photoelectric conversion elements. The apparatus also includes a transfer speed changing device for changing a transfer speed during a period of an accumulation operation of the photoelectric conversion device, making it possible to measure the luminance of an eye exactly in a short period of time.
摘要翻译： 一种装置包括具有多个光电转换元件的光电转换装置，用于将光转换为光电转换信号并将光电转换信号传送到相邻的光电转换元件。 该装置还包括用于在光电转换装置的累积操作期间改变传送速度的传送速度改变装置，使得可以在短时间内精确地测量眼睛的亮度。
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公开(公告)号：US5505847A
公开(公告)日：1996-04-09
申请号：US337744
申请日：1994-11-14
申请人： Hajime Yamada , Akira Yamada
发明人： Hajime Yamada , Akira Yamada
IPC分类号： A47K3/00 , A61H33/00 , A61H33/04 , B01D35/027 , C02F1/46
CPC分类号： A61H33/04 , A61H2033/0037 , A61H2033/048
摘要： The present invention is a bath which circulates and recycles a multiple mineral solution. The solution is released from the bathtub, filtered at the hair collector and the filtration device, sterilized at the electrolytic sterilizer, and returned to the tub. Non-metallic pipe is used along the circulation route. The electrolytic sterilizer employs several electrode panels which are placed perpendicular to the direction of flow of the solution. The filtration device features a rubber lining in the portions which come into contact with the solution, and has inside of it a dish onto which is lain filter sand. With the use of this invention, it becomes possible to repeatedly use and reuse a highly viscous solution containing multiple minerals as the recycling fluid, jams become infrequent, the filtration and reverse cleansing procedures become less time consuming, and the solution can be effectively sterilized.
摘要翻译： 本发明是一种使多种矿物质溶液循环和循环的浴。 溶液从浴缸中释放，在收集器和过滤装置处过滤，在电解消毒器处灭菌，并返回到桶中。 沿循环路线使用非金属管。 电解消毒器采用几个垂直于溶液流动方向放置的电极板。 过滤装置在与溶液接触的部分中具有橡胶衬里，并且在其内部具有用于过滤砂的盘。 通过使用本发明，可以重复使用和再利用含有多种矿物质的高粘度溶液作为再循环液，堵塞变得不频繁，过滤和反向清洗程序变得更加耗时，并且可以有效地消毒溶液。
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公开(公告)号：US5477492A
公开(公告)日：1995-12-19
申请号：US216388
申请日：1994-03-23
申请人： Akitoshi Ohsaki , Akira Yamada
发明人： Akitoshi Ohsaki , Akira Yamada
摘要： A memory device includes a redundant data-storage section as a spare for a normal data-storage section so that redundant data-holding circuitry repairs a defective area in normal data-holding circuitry. Data to be written is temporarily stored into a data holding section, and the data thus stored is written into the normal data-storage section and then it is read out immediately after the write operation. If the readout data is different from the initially written data, the destination of the write operation is switched to the redundant data-storage section so that the data held in the data holding section is written into the redundant data-storage section. If there is no discrepancy between these data, the destination of the write operation is then switched to the normal data-storage section so that the data held in the data holding section is written into the normal data-storage section.
摘要翻译： 存储装置包括作为正常数据存储部分的备用的冗余数据存储部分，使得冗余数据保持电路修复正常数据保持电路中的缺陷区域。 要写入的数据被临时存储到数据保持部分中，并且将如此存储的数据写入正常数据存储部分，然后在写入操作之后立即读出。 如果读出数据与初始写入的数据不同，则写入操作的目的地被切换到冗余数据存储部分，使得保存在数据保持部分中的数据被写入冗余数据存储部分。 如果这些数据之间没有差异，则将写入操作的目的地切换到正常数据存储部分，使得保存在数据保持部分中的数据被写入正常数据存储部分。
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