公开(公告)号：US08912225B2

公开(公告)日：2014-12-16

申请号：US11661460

申请日：2005-08-31

申请人： David L. Morris ,  Mohammad H. Pourgholami

发明人： David L. Morris ,  Mohammad H. Pourgholami

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/427

CPC分类号： A61K31/427 ,  A61K31/4184

摘要： The present invention provides methods for inhibiting VEGF production or secretion in a subject comprising administering to the subject an effective amount of a compound of Formula I. The invention also provides methods for the treatment or prevention of conditions associated with abnormal levels of VEGF production or secretion.

摘要翻译： 本发明提供了抑制受试者VEGF产生或分泌的方法，其包括向受试者施用有效量的式I化合物。本发明还提供治疗或预防与VEGF产生或分泌异常水平相关的病症的方法 。

公开(公告)号：US08265649B1

公开(公告)日：2012-09-11

申请号：US10645298

申请日：2003-08-21

申请人： Keith E. Moll ,  Khaled F. Al-Khashti ,  Brent A. Burpee ,  David L. Morris

发明人： Keith E. Moll ,  Khaled F. Al-Khashti ,  Brent A. Burpee ,  David L. Morris

IPC分类号： H04W24/00

CPC分类号： H04W64/003 ,  H04W4/90 ,  H04W76/10

摘要： A method and system for determining reporting the location of an originating telephone device. A location interoperability platform receives a signaling message from a switch, reflecting a call request from an originating device and carrying data indicating whether the originating device is a landline device or a wireless device. If the data indicates that the originating device is a landline device, then the location interoperability platform invokes a landline location-determination process to determine the location of the originating device. On the other hand, if the data indicates that the originating device is a wireless device, then the location interoperability platform invokes a wireless location-determination process to determine the location of the originating device. The location interoperability platform may then report the determined location to the called party, to help facilitate a location-based service such as emergency response.

摘要翻译： 一种用于确定报告始发电话设备的位置的方法和系统。 位置互操作性平台从交换机接收信令消息，反映来自始发设备的呼叫请求，并携带指示始发设备是固定电话设备还是无线设备的数据。 如果数据指示始发设备是固定电话设备，则位置互操作平台调用固定电话位置确定过程以确定始发设备的位置。 另一方面，如果数据指示始发设备是无线设备，则位置互操作平台调用无线位置确定过程来确定始发设备的位置。 位置互操作性平台然后可以将确定的位置报告给被叫方，以帮助促进基于位置的服务，例如紧急响应。

公开(公告)号：US20090105317A1

公开(公告)日：2009-04-23

申请号：US11661460

申请日：2005-08-31

申请人： David L. Morris ,  Mohammad H. Pourgholami

发明人： David L. Morris ,  Mohammad H. Pourgholami

IPC分类号： A61K31/4184 ,  A61K31/427 ,  A61P9/00 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00

CPC分类号： A61K31/427 ,  A61K31/4184

摘要： The present invention provides methods for inhibiting VEGF production or secretion in a subject comprising administering to the subject an effective amount of a compound of Formula I. The invention also provides methods for the treatment or prevention of conditions associated with abnormal levels of VEGF production or secretion.

摘要翻译： 本发明提供了抑制受试者VEGF产生或分泌的方法，其包括向受试者施用有效量的式I化合物。本发明还提供治疗或预防与VEGF产生或分泌异常水平相关的病症的方法 。

公开(公告)号：US20090076497A1

公开(公告)日：2009-03-19

申请号：US11893911

申请日：2007-08-17

申请人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

发明人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

IPC分类号： A61B18/14

CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.

公开(公告)号：US20080187560A1

公开(公告)日：2008-08-07

申请号：US11702396

申请日：2007-02-05

申请人： Geoffrey R. Haas ,  Robert C. Kerr ,  Carolina Mateus ,  David L. Morris ,  Bhawan Patel ,  Jenci Kurja

发明人： Geoffrey R. Haas ,  Robert C. Kerr ,  Carolina Mateus ,  David L. Morris ,  Bhawan Patel ,  Jenci Kurja

IPC分类号： A01N59/16 ,  A61K9/00 ,  B29C71/02

CPC分类号： C08K5/0091 ,  C08K3/015 ,  C08K3/10 ,  C08K3/24 ,  C08K5/0058 ,  C08K5/3432 ,  C08L21/00

摘要： This disclosure relates generally to molded rubber articles such as the type used in water contact applications. More particularly, this disclosure is directed to molded rubber articles containing antimicrobial agents that control biofilm growth on the surface of the molded article. The molded rubber article is comprised of curable rubber compounds and a combination of both inorganic silver-containing antimicrobial agents and organic antimicrobial agents. An exemplary molded rubber article comprises ethylene propylene diene monomer rubber, silver-containing ion exchange antimicrobial agent, and an organic antifungal agent such as zinc pyrithione.

摘要翻译： 本公开一般涉及模制橡胶制品，例如在水接触应用中使用的类型。 更具体地说，本公开涉及包含控制模制品表面上的生物膜生长的抗微生物剂的模制橡胶制品。 模制橡胶制品由可固化橡胶化合物和无机含银抗微生物剂和有机抗微生物剂的组合组成。 示例性的模制橡胶制品包括乙烯丙烯二烯单体橡胶，含银离子交换抗微生物剂和有机抗真菌剂如吡啶硫酮锌。

公开(公告)号：US07399299B2

公开(公告)日：2008-07-15

申请号：US10889756

申请日：2004-07-12

申请人： Steven A. Daniel ,  David L. Morris

发明人： Steven A. Daniel ,  David L. Morris

IPC分类号： A61B18/18

CPC分类号： A61B18/148 ,  A61B2018/00267

摘要： An ablation device is described comprising an introducer and an electrode array. The electrode array couples to a distal end of the introducer. The electrode array includes a center member having a distal end configured to penetrate tissue and a plurality of electrodes. Proximal and distal ends of each electrode are relatively fixed. The electrodes are dynamically configurable from a retracted state to a deployed state in which the electrodes form a relatively spherical shape in a tissue volume.

摘要翻译： 描述了包括导引器和电极阵列的消融装置。 电极阵列耦合到导引器的远端。 电极阵列包括具有构造成穿透组织的远端和多个电极的中心构件。 每个电极的近端和远端相对固定。 电极可以从缩回状态动态地配置到展开状态，其中电极在组织体积中形成相对球形的形状。

公开(公告)号：US07341586B2

公开(公告)日：2008-03-11

申请号：US10890055

申请日：2004-07-12

申请人： Steven A. Daniel ,  David L. Morris

发明人： Steven A. Daniel ,  David L. Morris

IPC分类号： A61B18/18

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： A coagulation system is provided for use in biological tissue. The coagulation system includes a handle, a radiofrequency (RF) generator, and an electrode array. The electrode array includes two or more pair of bipolar electrodes slideably coupled in channels of the handle. The bipolar electrodes electrically couple to the RF generator, and the electrode array is configured to deliver a balanced energy density in a target volume of the biological tissue. The balanced energy density delivered by the electrode array results in thermal coagulation necrosis of a rectangular volume of biological tissue.

摘要翻译： 提供用于生物组织的凝血系统。 凝结系统包括手柄，射频（RF）发生器和电极阵列。 电极阵列包括可滑动地联接在手柄的通道中的两对或更多对双极电极。 双极电极电耦合到RF发生器，并且电极阵列被配置为在生物组织的靶体积中传递平衡的能量密度。 由电极阵列传递的平衡能量密度导致生物组织的矩形体积的热凝固坏死。

公开(公告)号：US07223264B2

公开(公告)日：2007-05-29

申请号：US10800451

申请日：2004-03-15

申请人： Steven A. Daniel ,  David L. Morris

发明人： Steven A. Daniel ,  David L. Morris

IPC分类号： A61B18/18

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： Methods for performing coagulation necrosis of biological tissue are provided. The methods include configuring electrode arrays to provide balanced energy density in target tissue volumes using two or more pair of electrodes. The electrode array configuration includes at least one of irregular spacing between one or more pairs of electrodes and one or more electrode diameters. The methods further include deploying each electrode of an array at a selected depth in the target tissue volume in accordance with the configuration. Energy is then delivered to the target tissue volume using power sources coupled to the electrodes. The methods control power delivery in response to at least one of elapsed time of delivery, temperatures of the target tissue volume, and impedance levels in the target tissue volume to provide balanced or uniform energy throughout the target tissue volume. The methods generate planes of coagulated tissue.

摘要翻译： 提供了生物组织凝固坏死的方法。 所述方法包括配置电极阵列以使用两对或更多对电极在目标组织体积中提供平衡的能量密度。 电极阵列配置包括一对或多对电极之间的不规则间隔和一个或多个电极直径中的至少一个。 所述方法还包括根据配置将阵列的每个电极部署在目标组织体积中的选定深度处。 然后使用耦合到电极的电源将能量输送到目标组织体积。 所述方法响应于经过的传递时间，目标组织体积的温度和目标组织体积中的阻抗水平中的至少一个来控​​制功率传递，以在整个目标组织体积中提供平衡或均匀的能量。 该方法产生凝结组织的平面。

公开(公告)号：US07008421B2

公开(公告)日：2006-03-07

申请号：US10413112

申请日：2003-04-14

申请人： Steven A. Daniel ,  David L. Morris

发明人： Steven A. Daniel ,  David L. Morris

IPC分类号： A61B18/18

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： A tissue ablation system is described that generates a uniform avascular plane of coagulated tissue to aid in the bloodless or near-bloodless resection of various biological tissues from a variety of organs. The tissue ablation system includes an energy director guide and two or more sets of bipolar energy directors. The energy director guide includes a series of channels that configure the energy directors to provide approximately uniform power distribution or current density through a target tissue volume or plane. The spacing among the channels of the energy director guide varies according to the total number of energy directors received in the energy director guide so that relative spacing among the center-most channels is largest and relative spacing among the end-most channels is smallest. The energy director guide secures a selected position of each of the energy directors in the target tissue volume.

公开(公告)号：US06852782B2

公开(公告)日：2005-02-08

申请号：US10424112

申请日：2003-04-25

申请人： Bhawan Patel ,  David L. Morris

发明人： Bhawan Patel ,  David L. Morris

IPC分类号： C08K3/00 ,  C08K3/08 ,  C08K3/22 ,  C08K5/09

CPC分类号： C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

摘要： This invention relates to certain non-silicone vulcanized rubber articles that are made from at least a majority by weight of epichlorohydrin, polybutadiene, or polychloroprene vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as peroxide curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of epichlorohydrin, polybutadiene, or polychloroprene rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured rubber articles made therefrom.

摘要翻译： 本发明涉及由至少大部分重量的表氯醇，聚丁二烯或聚氯丁二烯硫化橡胶制成的某些非硅氧烷硫化橡胶制品，其包括银基化合物，以在固化的橡胶制品中提供高度期望的长期抗微生物特性 。 这样的制品是固体或吹制（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如过氧化物固化的试剂的存在，其允许硫化并且不会不可逆地将银离子结合到其上，从而导致最终橡胶制品本身的长期抗微生物性能。 本发明还包括由至少大部分重量的表氯醇，聚丁二烯或聚氯丁二烯橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终固化橡胶中提供高度期望的长期抗微生物特性 由此制成的物品。