公开(公告)号：US20150343175A1

公开(公告)日：2015-12-03

申请号：US14825336

申请日：2015-08-13

申请人： Covidien LP

发明人： Richard Braga

IPC分类号： A61M25/00 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61M25/0084 ,  A61M2025/006 ,  A61M2025/0085 ,  A61M2025/0089 ,  A61M2025/0093 ,  A61M2025/1086

摘要： A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

摘要翻译： 流体输送导管，其使用微针来通过血管壁进行流体输送。 导管可以为各种程序提供流体输送治疗，例如递送肿胀液或肾去神经支配。 导管包括细长构件，该细长构件设置在细长构件的远端周围。 针可以围绕远端径向地和/或沿着远端的长度设置。

公开(公告)号：US09108030B2

公开(公告)日：2015-08-18

申请号：US13826237

申请日：2013-03-14

申请人： Covidien LP

发明人： Richard M. Braga

IPC分类号： A61M37/00 ,  A61M25/10 ,  A61M25/00

CPC分类号： A61M37/0015 ,  A61M25/0084 ,  A61M2025/006 ,  A61M2025/0085 ,  A61M2025/0089 ,  A61M2025/0093 ,  A61M2025/1086

摘要： A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

摘要翻译： 流体输送导管，其使用微针来通过血管壁进行流体输送。 导管可以为各种程序提供流体输送治疗，例如递送肿胀液或肾去神经支配。 导管包括细长构件，该细长构件设置在细长构件的远端周围。 针可以围绕远端径向地和/或沿着远端的长度设置。

公开(公告)号：US08948865B2

公开(公告)日：2015-02-03

申请号：US14081634

申请日：2013-11-15

申请人： Medtronic Ardian Luxembourg S.a.r.l.

发明人： Denise Zarins ,  Hanson Gifford, III

IPC分类号： A61N1/36 ,  A61B18/14 ,  A61N1/05 ,  A61N1/32 ,  A61F7/00 ,  A61M5/00 ,  A61N7/02

CPC分类号： A61M25/0084 ,  A61B17/3478 ,  A61B18/04 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61F7/007 ,  A61K38/4893 ,  A61M5/00 ,  A61M2025/0085 ,  A61M2202/0007 ,  A61M2210/1082 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/32 ,  A61N1/36017 ,  A61N1/36114 ,  A61N7/02 ,  C12Y304/24069

摘要： Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, such neuromodulation is achieved through application of an electric field. In some embodiments, such neuromodulation is achieved through application of neuromodulatory agents, of thermal energy and/or of high intensity focused ultrasound. In some embodiments, such neuromodulation is performed in a bilateral fashion.

摘要翻译： 提供了通过肾脏神经调节治疗心律失常的方法和装置。 这种神经调节可以实现不可逆的电穿孔或电融合，消融，坏死和/或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其它条件。 在一些实施例中，通过施加电场来实现这种神经调节。 在一些实施方案中，通过应用神经调节剂，热能和/或高强度聚焦超声来实现这种神经调节。 在一些实施方案中，这种神经调节以双向方式进行。

公开(公告)号：US07621895B2

公开(公告)日：2009-11-24

申请号：US11436709

申请日：2006-05-17

申请人： Geoffrey H. Willis ,  Eric Willis ,  Shuji Uemura ,  Mike Stewart ,  Alfredo Cantu

发明人： Geoffrey H. Willis ,  Eric Willis ,  Shuji Uemura ,  Mike Stewart ,  Alfredo Cantu

IPC分类号： A61M5/00

CPC分类号： A61M25/0084 ,  A61M25/0068 ,  A61M25/1006 ,  A61M2005/341 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/0085 ,  A61M2025/0087 ,  A61M2025/0096

摘要： Methods and delivery devices for maximizing injectate dispersion in lesioned tissue using needle-based injection devices are herein disclosed. The delivery devices include injection devices with various needle arrays and/or modified needle tip configurations. The needle tip configurations can include linear, hooked or corkscrew tips and/or multiple circumferential openings.

摘要翻译： 本文公开了使用基于针的注射装置使损伤组织中的注射分散最大化的方法和递送装置。 递送装置包括具有各种针阵列和/或修改的针尖构造的注射装置。 针尖构造可以包括线性，钩形或开瓶器尖端和/或多个周向开口。

公开(公告)号：US07422586B2

公开(公告)日：2008-09-09

申请号：US09797409

申请日：2001-02-28

申请人： David L. Morris ,  Steven A. Daniel ,  Daniel J. Balbierz

发明人： David L. Morris ,  Steven A. Daniel ,  Daniel J. Balbierz

IPC分类号： A61B18/18

CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

摘要： A tissue surface reatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactine surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy deliveru device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode fdro the housing interior into the target tissuesite and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.

摘要翻译： 组织表面恢复装置包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。 接触面具有多个孔。 包括电极的能量输送装置可定位在壳体内部。 电极包括与孔基本对准的穿透远端的组织。 电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。 进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。 推进装置被配置为使电极将壳体内部推进到目标组织中并将电极撤回到壳体内部。 电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

公开(公告)号：US20080065002A1

公开(公告)日：2008-03-13

申请号：US11850156

申请日：2007-09-05

申请人： Thomas J. Lobl ,  John V. Schloss ,  Anna Imola Nagy ,  Jacob E. Pananen

发明人： Thomas J. Lobl ,  John V. Schloss ,  Anna Imola Nagy ,  Jacob E. Pananen

IPC分类号： A61N1/30

CPC分类号： A61M25/0068 ,  A61M25/003 ,  A61M25/007 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/0082 ,  A61M2025/0037 ,  A61M2025/004 ,  A61M2025/0073 ,  A61M2025/0085 ,  A61N1/30 ,  A61N1/36036

摘要： A drug-compatible, biocompatible, drug-delivery catheter can include multi-lumen tubing attached to an end fitting, with the end fitting having an internal fluid chamber and a fluid exit region. The catheter can also include multi-lumen tubing having one or more needles attached at a distal end.

摘要翻译： 药物相容的，生物相容的药物递送导管可以包括连接到端部配件的多腔管，其中端部配件具有内部流体室和流体出口区域。 导管还可以包括具有连接在远端的一个或多个针的多腔管。

公开(公告)号：US07278991B2

公开(公告)日：2007-10-09

申请号：US09938276

申请日：2001-08-22

申请人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

发明人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

IPC分类号： A61B18/18

CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.

摘要翻译： 控制消融体积深度的方法包括提供治疗装置。 该装置包括具有包括组织接触表面的近端和远端的壳体。 壳体限定具有可定位在内部的能量输送装置的内部。 能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。 一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。 将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。 能量从能量输送装置输送。 在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

公开(公告)号：US07087040B2

公开(公告)日：2006-08-08

申请号：US10074468

申请日：2002-02-12

申请人： James F. McGuckin, Jr. ,  Stephan A. DeFonzo

发明人： James F. McGuckin, Jr. ,  Stephan A. DeFonzo

IPC分类号： A61M5/178 ,  A61M5/32

CPC分类号： A61B18/00 ,  A61B2017/00867 ,  A61B2090/3937 ,  A61M25/0068 ,  A61M2025/0085 ,  A61M2025/0096

摘要： A surgical apparatus for delivering fluid to treat a lesion comprising a housing, an elongated member extending from the housing, and a plurality of tines positioned in the housing. Each of the tines has a lumen and at least one opening communicating with the lumen for delivering fluid to the lesion. An actuator is operatively associated with the tines and actuable to a first position to move the plurality of tines from a retracted position substantially within the elongated member to a first deployed position extending from the elongated member and actuable to a second position to move the plurality of tines from the first position to a second deployed position.

公开(公告)号：US11793394B2

公开(公告)日：2023-10-24

申请号：US16465621

申请日：2017-12-01

申请人： Vanderbilt University

发明人： Nicolo Garbin ,  Pietro Valdastri ,  Keith L. Obstein ,  Nabil Simaan ,  Piotr Robert Slawinski

IPC分类号： A61M25/01 ,  A61B1/005 ,  A61B1/273 ,  A61M25/00

CPC分类号： A61B1/0055 ,  A61B1/0052 ,  A61B1/2733 ,  A61M25/0084 ,  A61M25/0138 ,  A61M25/0155 ,  A61M2025/0085

摘要： A steerable endoscope system includes a continuum manipulator, a plurality of syringes, and a steerable tip. The continuum manipulator includes a plurality of spaced discs and a plurality of backbones each extending through all discs. A bending movement of the continuum manipulator changes a varying linear displacement of each backbone. Each backbone is further coupled to a different one of the syringes such that the linear displacement of each backbone pushes or pulls a piston of the corresponding syringe by a varying amount. The steerable tip includes a plurality of bellows each pneumatically coupled to a different syringe such that movement of the piston of a syringe causes the corresponding bellow to inflate or deflate. Because the distal end of each bellow is fixedly coupled to the same end effector, variations in the amount of inflation or deflation on each bellow causes a bending of the steerable tip.

公开(公告)号：US09072596B1

公开(公告)日：2015-07-07

申请号：US13651682

申请日：2012-10-15

申请人： Sidney Lowell Kahn ,  Wael Saad ,  Brent Seybold

发明人： Sidney Lowell Kahn ,  Wael Saad ,  Brent Seybold

IPC分类号： A61M5/00 ,  A61M5/32 ,  A61F2/06 ,  A61M27/00

CPC分类号： A61F2/06 ,  A61B17/3417 ,  A61B17/3478 ,  A61B2017/003 ,  A61B2017/00455 ,  A61B2017/306 ,  A61M25/0068 ,  A61M25/0084 ,  A61M25/0606 ,  A61M27/002 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0681

摘要： An apparatus method for establishing a Transjugular Intrahepatic Portosystemic Shunt between the portal vein from a hepatic vein. The apparatus comprises an elongated hollow outer guide; an outer handle having an inner lumen and a first luer lock, the outer handle attached at a proximal end of the outer guide, the outer guide in flow communication with the inner lumen and the luer lock; an elongated hollow inner needle; and a hub having a second luer lock, the hub attached at a proximal end of the inner needle, the inner needle in flow communication with the second luer lock. The inner needle is slidingly received into the outer guide through the inner lumen. The inner needle is configured to rotate within the outer guide by manipulation of the hub; and a distal tip of the inner needle is deployed out of and beyond a distal tip of the outer guide.

摘要翻译： 一种用于在肝静脉门静脉之间建立经颈静脉肝内门静脉分流的装置方法。 该装置包括细长的中空外引导件; 外部手柄，其具有内腔和第一鲁尔锁，所述外手柄附接在所述外引导件的近端处，所述外引导件与所述内腔和所述鲁尔锁流动连通; 细长的中空内针; 以及具有第二鲁尔锁的轮毂，所述轮毂安装在所述内针的近端处，所述内针与所述第二鲁尔锁流动连通。 内针通过内腔滑动地容纳在外引导件中。 内针构造成通过操纵毂而在外引导件内旋转; 并且内针的远侧末端被展开在外引导件的远端之外并且超出外引导件的远端。