公开(公告)号：US06943205B2

公开(公告)日：2005-09-13

申请号：US10423204

申请日：2003-04-25

申请人： Bhawan Patel ,  David L. Morris

发明人： Bhawan Patel ,  David L. Morris

IPC分类号： C08K3/00 ,  C08K3/08 ,  C08K3/22 ,  C08K5/09 ,  C08K5/10 ,  C08K5/12 ,  C08K5/34

CPC分类号： C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

摘要： This invention relates to certain non-silicone vulcanized rubber articles that are made from at least a majority by weight of vulcanized styrene butadiene rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as peroxide curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of styrene butadiene rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured rubber articles made therefrom.

摘要翻译： 本发明涉及由至少大部分重量的硫化苯乙烯丁二烯橡胶制成的某些非硅氧烷硫化橡胶制品，其包括银基化合物，以在固化的橡胶制品中提供非常理想的长期抗菌特性。 这样的制品是固体或吹制（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如过氧化物固化的试剂的存在，其允许硫化并且不会不可逆地将银离子结合到其上，从而导致最终橡胶制品本身的长期抗微生物性能。 本发明还包括由至少大部分重量的苯乙烯丁二烯橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在由其制成的最终固化的橡胶制品中提供高度期望的长期抗微生物特性。

公开(公告)号：US07060739B2

公开(公告)日：2006-06-13

申请号：US10424024

申请日：2003-04-25

申请人： Bhawan Patel ,  David L. Morris

发明人： Bhawan Patel ,  David L. Morris

IPC分类号： C08K3/08 ,  C08K3/10 ,  C08K3/34 ,  C08K5/09

CPC分类号： C08K5/0025 ,  A01N59/16 ,  C08K3/013 ,  C08K3/015 ,  A01N25/10 ,  A01N2300/00 ,  C08L27/12

摘要： Fluoroelastomer (FKM) rubber-containing articles that exhibit highly desirable long-term effective antimicrobial characteristics are provided. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of applications. This invention utilizes the presence of non-sulfur-based curing systems and agents, such as bisphenols, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the rubber article. This invention further provides a simple method of producing such an antimicrobial vulcanized fluoroelastomer rubber-containing article. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of FKM rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured FKM articles made therefrom.

摘要翻译： 提供了显示出非常期望的长期有效抗微生物特性的含氟弹性体（FKM）橡胶制品。 这样的制品是固体或吹制（泡沫或海绵）状态（或多层形式的两者的组合），并且可以用于各种应用中。 本发明利用了非硫基固化体系和诸如双酚的试剂，其允许硫化并且不会不可逆地结合银离子，从而导致橡胶制品的长期抗菌性能。 本发明还提供了一种制备这种抗微生物硫化含氟弹性体橡胶的制品的简单方法。 本发明还包括由至少大部分重量比的FKM橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在由其制成的最终固化的FKM制品中提供高度期望的长期抗微生物特性。

公开(公告)号：US20080187560A1

公开(公告)日：2008-08-07

申请号：US11702396

申请日：2007-02-05

申请人： Geoffrey R. Haas ,  Robert C. Kerr ,  Carolina Mateus ,  David L. Morris ,  Bhawan Patel ,  Jenci Kurja

发明人： Geoffrey R. Haas ,  Robert C. Kerr ,  Carolina Mateus ,  David L. Morris ,  Bhawan Patel ,  Jenci Kurja

IPC分类号： A01N59/16 ,  A61K9/00 ,  B29C71/02

CPC分类号： C08K5/0091 ,  C08K3/015 ,  C08K3/10 ,  C08K3/24 ,  C08K5/0058 ,  C08K5/3432 ,  C08L21/00

摘要： This disclosure relates generally to molded rubber articles such as the type used in water contact applications. More particularly, this disclosure is directed to molded rubber articles containing antimicrobial agents that control biofilm growth on the surface of the molded article. The molded rubber article is comprised of curable rubber compounds and a combination of both inorganic silver-containing antimicrobial agents and organic antimicrobial agents. An exemplary molded rubber article comprises ethylene propylene diene monomer rubber, silver-containing ion exchange antimicrobial agent, and an organic antifungal agent such as zinc pyrithione.

摘要翻译： 本公开一般涉及模制橡胶制品，例如在水接触应用中使用的类型。 更具体地说，本公开涉及包含控制模制品表面上的生物膜生长的抗微生物剂的模制橡胶制品。 模制橡胶制品由可固化橡胶化合物和无机含银抗微生物剂和有机抗微生物剂的组合组成。 示例性的模制橡胶制品包括乙烯丙烯二烯单体橡胶，含银离子交换抗微生物剂和有机抗真菌剂如吡啶硫酮锌。

公开(公告)号：US06852782B2

公开(公告)日：2005-02-08

申请号：US10424112

申请日：2003-04-25

申请人： Bhawan Patel ,  David L. Morris

发明人： Bhawan Patel ,  David L. Morris

IPC分类号： C08K3/00 ,  C08K3/08 ,  C08K3/22 ,  C08K5/09

CPC分类号： C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

摘要： This invention relates to certain non-silicone vulcanized rubber articles that are made from at least a majority by weight of epichlorohydrin, polybutadiene, or polychloroprene vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as peroxide curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of epichlorohydrin, polybutadiene, or polychloroprene rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured rubber articles made therefrom.

摘要翻译： 本发明涉及由至少大部分重量的表氯醇，聚丁二烯或聚氯丁二烯硫化橡胶制成的某些非硅氧烷硫化橡胶制品，其包括银基化合物，以在固化的橡胶制品中提供高度期望的长期抗微生物特性 。 这样的制品是固体或吹制（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如过氧化物固化的试剂的存在，其允许硫化并且不会不可逆地将银离子结合到其上，从而导致最终橡胶制品本身的长期抗微生物性能。 本发明还包括由至少大部分重量的表氯醇，聚丁二烯或聚氯丁二烯橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终固化橡胶中提供高度期望的长期抗微生物特性 由此制成的物品。

公开(公告)号：US06846871B2

公开(公告)日：2005-01-25

申请号：US10424025

申请日：2003-04-25

申请人： Bhawan Patel ,  David L. Morris

发明人： Bhawan Patel ,  David L. Morris

IPC分类号： C08K3/00 ,  C08K3/08 ,  C08K3/22

CPC分类号： C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

摘要： This invention relates to certain non-silicone resin cured rubber articles that are made from at least a majority by weight of non-silicone vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as resin curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of non-silicone rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate resin cured rubber articles made therefrom.

摘要翻译： 本发明涉及由至少大部分重量的非硅氧烷硫化橡胶制成的某些非硅树脂固化橡胶制品，其包括银基化合物，以在固化的橡胶制品内提供高度期望的长期抗菌特性。 这样的制品是固体或吹制（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如树脂固化的试剂的存在，其允许硫化并且不会不可逆地将银离子结合到其上，从而导致最终橡胶制品本身的长期抗微生物性能。 本发明还包括由至少大部分重量的非硅橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终树脂固化橡胶制品中提供非常期望的长期抗微生物特性 由此。

公开(公告)号：US06638993B2

公开(公告)日：2003-10-28

申请号：US10015878

申请日：2001-12-12

申请人： Bhawan Patel ,  David L. Morris ,  Geoffrey Haas ,  William O. Burke, III

发明人： Bhawan Patel ,  David L. Morris ,  Geoffrey Haas ,  William O. Burke, III

IPC分类号： C08K509

CPC分类号： C08K3/34 ,  C08K3/015 ,  C08K5/0058 ,  C08L21/00 ,  C08L23/16

摘要： Certain non-silicone vulcanized rubber articles made from at least a majority by weight of ethylene-propylene-diene modified (terpolymer) rubber (such as, without limitation, EPDM and/or NBR) that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles, at least a portion of which exhibits a color other than black, are provided. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms, either all colored or individual layers colored) that can be utilized in a variety of different applications. As silver-based compounds are deleteriously affected by utilization of standard curing agents and curing accelerators, such as sulfur-based compounds and/or systems, the ability to provide such an effective antimicrobial vulcanized rubber article is rather difficult. However, this invention encompasses the presence of different non-sulfur-based curing systems and agents, such as peroxides, as one example, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. The rubber articles must also comprise fillers and may also include plasticizers to provide desired characteristics of dimensional stability, stiffness, flexural modulus, tensile strength, abrasion resistance, elongation, and the like, for the ultimate rubber article, while simultaneously and surprisingly both enhancing the control of antimicrobial efficacy of the rubber article and not deleteriously binding to the available silver to permit coloring of the target rubber as well.

公开(公告)号：US20120214856A1

公开(公告)日：2012-08-23

申请号：US13457860

申请日：2012-04-27

申请人： David L. Morris ,  Mohammad Hossein Pourgholami

发明人： David L. Morris ,  Mohammad Hossein Pourgholami

IPC分类号： A61K31/4184 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00

CPC分类号： A61K31/427 ,  A61K31/337 ,  A61K31/4184

摘要： The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol carbamate compound of formula (I). The invention also provides a method for the treatment of tumors insensitive to one or more anti-mitotic drugs, the method comprising administering a effective amount of at least one benzimidazole carbamate compound of formula (I). Also provide are compositions for carrying out methods of the invention.

摘要翻译： 本发明提供了治疗肿瘤的方法，包括施用有效量的至少一种类紫杉素和有效量的至少一种式（I）的苯并咪唑氨基甲酸酯化合物。 本发明还提供了治疗对一种或多种抗有丝分裂药物不敏感的肿瘤的方法，所述方法包括施用有效量的式（I）的至少一种苯并咪唑氨基甲酸酯化合物。 还提供了用于实施本发明方法的组合物。

公开(公告)号：US08216224B2

公开(公告)日：2012-07-10

申请号：US11893911

申请日：2007-08-17

申请人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

发明人： David L. Morris ,  Steve A. Daniel ,  Daniel J. Balbierz

IPC分类号： A61B18/14

CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.

摘要翻译： 控制消融体积深度的方法包括提供治疗装置。 该装置包括具有包括组织接触表面的近端和远端的壳体。 壳体限定具有可定位在内部的能量输送装置的内部。 能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。 一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。 将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。 能量从能量输送装置输送。 在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

公开(公告)号：US20080319436A1

公开(公告)日：2008-12-25

申请号：US12107034

申请日：2008-04-21

申请人： Steven A. Daniel ,  David L. Morris ,  Kee Sein Lee

发明人： Steven A. Daniel ,  David L. Morris ,  Kee Sein Lee

IPC分类号： A61B18/18 ,  A61B18/14

CPC分类号： A61B18/148 ,  A61B18/1477 ,  A61B18/1487 ,  A61B2018/00267

摘要： A tissue ablation system including numerous components and methods is described herein for encircling target tissue and generating tissue ablation volumes in various biological tissues. The biological tissue includes tissue of a variety of organs of the human body including the liver, spleen, kidney, lung, breast and other organs, but is not so limited. The tissue ablation device comprises an energy source and at least one trocar coupled to the energy source, the trocar having a body, a proximal end, and a distal end. The trocar carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the trocar when moved from a retracted state to a deployed state, and to have at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.

摘要翻译： 本文描述了包括许多组分和方法的组织消融系统，用于环绕靶组织并在各种生物组织中产生组织消融体积。 生物组织包括人体各种器官的组织，包括肝，脾，肾，肺，乳腺和其他器官，但不限于此。 组织消融装置包括能量源和耦合到能量源的至少一个套管针，套管针具有主体，近端和远端。 套针针携带包括多个电极的电极阵列，多个电极中的每个电极构造成当套管针从缩回状态移动到展开状态时延伸，并且在所展开的部分中具有至少一个曲率半径 使得电极阵列形成处于展开状态的一系列成形电极。

公开(公告)号：US20080312650A1

公开(公告)日：2008-12-18

申请号：US12139912

申请日：2008-06-16

申请人： Steven A. Daniel ,  David L. Morris

发明人： Steven A. Daniel ,  David L. Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/148 ,  A61B2018/00267

摘要： An ablation device is described comprising an introducer and an electrode array. The electrode array couples to a distal end of the introducer. The electrode array includes a center member having a distal end configured to penetrate tissue and a plurality of electrodes. Proximal and distal ends of each electrode are relatively fixed. The electrodes are dynamically configurable from a retracted state to a deployed state in which the electrodes form a relatively spherical shape in a tissue volume.

摘要翻译： 描述了包括导引器和电极阵列的消融装置。 电极阵列耦合到导引器的远端。 电极阵列包括具有构造成穿透组织的远端和多个电极的中心构件。 每个电极的近端和远端相对固定。 电极可以从缩回状态动态地配置到展开状态，其中电极在组织体积中形成相对球形的形状。