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57 条记录 (耗时 0.087 秒)

    Antibodies to human ErbB4
    52.
    发明申请
    Antibodies to human ErbB4 审中-公开
    人ErbB4抗体

    公开(公告)号：US20100190964A1

    公开(公告)日：2010-07-29

    申请号：US12753792

    申请日：2010-04-02

    申请人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    发明人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    IPC分类号： C07K16/18

    CPC分类号： C07K14/82 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5061

    摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

    摘要翻译： 本发明涉及通过使用天然ErbB4受体的拮抗剂来控制平滑肌细胞的过度增殖和/或迁移，特别是用于治疗狭窄的方法和手段。 本发明还涉及鉴定能够抑制或增强平滑肌细胞增殖或迁移的ErbB4激动剂和拮抗剂的方法。

    Antibodies to human ErbB4
    55.
    发明授权
    Antibodies to human ErbB4 有权
    人ErbB4抗体

    公开(公告)号：US07332579B2

    公开(公告)日：2008-02-19

    申请号：US10362380

    申请日：2001-08-29

    申请人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    发明人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C12P21/08

    CPC分类号： C07K14/82 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5061

    摘要： The present invention concerns isolated antibodies that specifically bind to the human ErbB4 of SEQ ID NO:2, as well as humanized antibodies, human antibodies and antibody fragments, as well as bispecific antibodies capable of binding both the human ErbB4 of SEQ ID NO:2 and ErbB3. The invention further concerns antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 with a Kd less than 100 nM, antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduces heregulin binding thereto, and antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduce heregulin-induced tyrosine phosphorylation thereof.

    摘要翻译： 本发明涉及与SEQ ID NO：2的人ErbB4以及人源化抗体，人抗体和抗体片段特异性结合的分离的抗体，以及能够结合SEQ ID NO：2的人ErbB4两者的双特异性抗体 和ErbB3。 本发明还涉及以小于100nM的Kd特异性结合SEQ ID NO：2的人ErbB4的抗体，特异性结合SEQ ID NO：2的人ErbB4的抗体，并且其特异性结合的抗体 与SEQ ID NO：2的人ErbB4结合，并且其降低其胰腺素诱导的酪氨酸磷酸化。

    Sphingosine kinases
    57.
    发明授权
    Sphingosine kinases 失效
    鞘氨醇激酶

    公开(公告)号：US06858427B2

    公开(公告)日：2005-02-22

    申请号：US09784810

    申请日：2001-02-14

    申请人： Mary E. Gerritsen ,  Luca Rastelli

    发明人： Mary E. Gerritsen ,  Luca Rastelli

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/12 ,  C12N15/54 ,  C12N15/52 ,  C12N15/63

    CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

    摘要： Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

    摘要翻译： 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。