公开(公告)号：US06858427B2

公开(公告)日：2005-02-22

申请号：US09784810

申请日：2001-02-14

申请人： Mary E. Gerritsen ,  Luca Rastelli

发明人： Mary E. Gerritsen ,  Luca Rastelli

IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/12 ,  C12N15/54 ,  C12N15/52 ,  C12N15/63

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

摘要： Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20090136997A1

公开(公告)日：2009-05-28

申请号：US11929465

申请日：2007-10-30

申请人： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

发明人： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C12P21/02 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N9/96 ,  C12N9/02 ,  C12N1/21 ,  C12N1/19

CPC分类号： C07K14/705 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/30 ,  C07K2319/40

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07456261B2

公开(公告)日：2008-11-25

申请号：US10219061

申请日：2002-08-12

申请人： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

发明人： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07H21/04 ,  C07K14/435 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

摘要： The present invention is directed to antibodies which bind to PRO9830 polypeptides.

摘要翻译： 本发明涉及结合PRO9830多肽的抗体。

公开(公告)号：US20080241159A1

公开(公告)日：2008-10-02

申请号：US12046795

申请日：2008-03-12

申请人： Mary E. Gerritsen ,  Jo-Anne S. Hongo ,  Constance H. Zlot

发明人： Mary E. Gerritsen ,  Jo-Anne S. Hongo ,  Constance H. Zlot

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P9/00

CPC分类号： C07K14/575 ,  A61K38/00

摘要： The invention provides methods and compositions for modulating vascularization and angiogenesis, including selective modulation of stages of multi-step vascularization and angiogenesis.

摘要翻译： 本发明提供用于调节血管形成和血管生成的方法和组合物，包括多步血管形成和血管发生的阶段的选择性调节。

公开(公告)号：US20080182275A1

公开(公告)日：2008-07-31

申请号：US11786466

申请日：2007-04-10

申请人： Avi J Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12N15/63 ,  C12N5/06 ,  C12N5/16 ,  C12N1/21 ,  C12N1/19 ,  C12P21/00 ,  C07K2/00 ,  C07K16/46 ,  C07K16/18 ,  G01N33/566

CPC分类号： C07K14/47 ,  G01N33/6872

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07189563B2

公开(公告)日：2007-03-13

申请号：US10063703

申请日：2002-05-08

申请人： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

发明人： Dan L. Eaton ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/82 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/40 ,  C07K2319/30 ,  C12N5/06 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07160993B2

公开(公告)日：2007-01-09

申请号：US10152375

申请日：2002-05-21

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07029874B2

公开(公告)日：2006-04-18

申请号：US10013917

申请日：2001-10-25

申请人： Kevin P. Baker ,  Luc Desnoyers ,  Dan L. Eaton ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sophia S. Kuo ,  James Pan ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  William I. Wood

发明人： Kevin P. Baker ,  Luc Desnoyers ,  Dan L. Eaton ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sophia S. Kuo ,  James Pan ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N15/74 ,  C12N5/02 ,  C07K14/00

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07018837B2

公开(公告)日：2006-03-28

申请号：US09944884

申请日：2001-08-31

申请人： Kevin P. Baker ,  David Botstein ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Mary A. Napier ,  Margaret Ann Roy ,  Daniel Tumas ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Mary A. Napier ,  Margaret Ann Roy ,  Daniel Tumas ,  William I. Wood

IPC分类号： C12N15/85 ,  C12N1/21 ,  C12N1/19 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K14/47 ,  C07H21/04 ,  C07K2319/00

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US08222271B2

公开(公告)日：2012-07-17

申请号：US11726813

申请日：2007-03-23

申请人： David M. Kleinman ,  Thierry Nivaggioli ,  Mary E. Gerritsen ,  David A. Weber

发明人： David M. Kleinman ,  Thierry Nivaggioli ,  Mary E. Gerritsen ,  David A. Weber

IPC分类号： A01N43/42 ,  A61K31/44

CPC分类号： A61K31/436 ,  A61K47/10

摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.

摘要翻译： 本文描述了用于治疗，抑制，预防，延缓发作或导致与血管通透性有关的疾病或病症消退的制剂和方法。