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    Intradermal delivery device and method
    52.
    发明授权
    Intradermal delivery device and method 失效
    皮内输送装置及方法

    公开(公告)号：US06971999B2

    公开(公告)日：2005-12-06

    申请号：US10294926

    申请日：2002-11-14

    Applicant: Daniel Py ,  Julian V. Chan

    Inventor： Daniel Py ,  Julian V. Chan

    IPC: A61M20060101 ,  A61M5/00 ,  A61M5/24 ,  A61M5/315 ,  A61M5/32 ,  A61M5/42 ,  A61M5/46

    CPC classification number: A61M5/425 ,  A61M5/24 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/3287 ,  A61M5/46

    Abstract: The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.

    Abstract translation: 受试者皮内递送装置提供穿透至固定深度，而不需要用户的专门知识。 该装置由嵌套在内壳和外壳内的注射器组成。 在内壳和外壳之间形成细长的环形通道。 壳体以滑动接合的方式接收注射器和同心壳体。 在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。 当将该装置应用于皮肤时，壳体和注射器朝向皮肤滑动，并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。 结果，皮肤被横跨内壳张紧，以形成基本上平坦的，拉紧的皮肤目标区域。 与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。

    One-way valve and apparatus and method of using the valve
    58.
    发明授权
    One-way valve and apparatus and method of using the valve 有权
    单向阀及其使用方法及阀门

    公开(公告)号：US08104644B2

    公开(公告)日：2012-01-31

    申请号：US12901422

    申请日：2010-10-08

    Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

    Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

    IPC: B65D37/00

    CPC classification number: B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

    Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

    Abstract translation: 提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。 柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。 组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。 组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。

    DISPENSER AND APPARATUS AND METHOD FOR FILLING A DISPENSER
    59.
    发明申请
    DISPENSER AND APPARATUS AND METHOD FOR FILLING A DISPENSER 有权
    分配器和装置以及填充分配器的方法

    公开(公告)号：US20110297677A1

    公开(公告)日：2011-12-08

    申请号：US12984482

    申请日：2011-01-04

    Applicant: Daniel Py ,  Julian V. Chan

    Inventor： Daniel Py ,  Julian V. Chan

    IPC: B65D47/00 ,  B65B1/04 ,  B65D37/00

    CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

    Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

    Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

    CONTAINER AND ONE-WAY VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD
    60.
    发明申请
    CONTAINER AND ONE-WAY VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD 有权
    用于储存和分配物质的集装箱和单向阀组件及相关方法

    公开(公告)号：US20110073614A1

    公开(公告)日：2011-03-31

    申请号：US12962087

    申请日：2010-12-07

    Applicant: Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

    Inventor： Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

    IPC: B67D7/00

    CPC classification number: B65D51/226 ,  B65D47/2075

    Abstract: A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a head located at one end of the body and a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber, and a first connecting portion for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and at least one piercing portion engageable with the pierceable wall of the container. The valve assembly includes a second connecting portion connectable to the first connecting portion of the container for fixedly securing the valve assembly to the container.

    Abstract translation: 用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。 容器包括位于主体一端的头部和与主体的储存室流体连通并限定其间的流路的第一通道。 容器还包括位于通道相对于储存室的相对侧上的可穿透壁，以及用于将另一部件连接到其上的第一连接部分。 该装置还包括单向阀组件，该单向阀组件包括阀体，该阀体包括限定第二通道的主体基座和与容器的可刺穿壁可接合的至少一个穿孔部分。 阀组件包括可连接到容器的第一连接部分的第二连接部分，用于将阀组件固定地固定到容器。

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