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公开(公告)号：US08707619B2
公开(公告)日：2014-04-29
申请号：US12682353
申请日：2008-10-08
IPC分类号： A01G9/02
CPC分类号： A01G9/02 , A01G7/00 , B01D53/85 , B01D2257/2064 , B01D2257/502 , B01D2257/70 , B01D2257/7027 , B01D2259/4508 , F24F2003/1653 , F24F2006/005 , Y02A50/2359
摘要： A novel apparatus for the treatment, e.g., cleaning, humidifying, filtration and/or detoxifying, of ambient air incorporates a plant, soil, roots and a water reservoir to allow for effective filtration of air over an extended period of time. In particular, the device is designed with an air impeller system such that external “dirty” air is circulated within the device in the proximity of the plant, soil, roots and/or water reservoir, thereby removing impurities, toxins and other undesirable chemicals from the air. The apparatus and methods of the present invention are readily applicable to a number of applications where air treatment is desired, e.g., household use. Moreover, by incorporating a plant system, the apparatus serves not only a functional but an aesthetic purpose as well.
摘要翻译： 用于治疗，例如清洁，加湿，过滤和/或解毒环境空气的新型装置包括植物，土壤，根部和水贮存器，以允许在长时间内有效地过滤空气。 特别地，该装置设计有空气叶轮系统，使得外部“脏”空气在装置内在植物，土壤，根部和/或水储存器附近循环，从而从杂质，毒素和其他不期望的化学物质中除去 空气。 本发明的装置和方法可以容易地应用于需要空气处理的许多应用，例如家用。 此外，通过结合植物系统，该装置不仅起到功能性的作用，而且起到美学的作用。
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公开(公告)号：US20120093893A1
公开(公告)日：2012-04-19
申请号：US13334236
申请日：2011-12-22
IPC分类号： A61K9/14 , A61P11/00 , A61K31/192 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。
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公开(公告)号：US20110094156A1
公开(公告)日：2011-04-28
申请号：US12682353
申请日：2008-10-08
CPC分类号： A01G9/02 , A01G7/00 , B01D53/85 , B01D2257/2064 , B01D2257/502 , B01D2257/70 , B01D2257/7027 , B01D2259/4508 , F24F2003/1653 , F24F2006/005 , Y02A50/2359
摘要： A novel apparatus for the treatment, e.g., cleaning, humidifying, filtration and/or detoxifying, of ambient air incorporates a plant, soil, roots and a water reservoir to allow for effective filtration of air over an extended period of time. In particular, the device is designed with an air impeller system such that external ‘dirty’ air is circulated within the device in the proximity of the plant, soil, roots and/or water reservoir, thereby removing impurities, toxins and other undesirable chemicals from the air. The apparatus and methods of the present invention are readily applicable to a number of applications where air treatment is desired, e.g., household use. Moreover, by incorporating a plant system, the apparatus serves not only a functional but an aesthetic purpose as well.
摘要翻译： 用于治疗，例如清洁，加湿，过滤和/或解毒环境空气的新型装置包括植物，土壤，根部和水贮存器，以允许在长时间内有效地过滤空气。 特别地，该装置设计有空气叶轮系统，使得外部“脏”空气在装置内在植物，土壤，根部和/或水储存器附近循环，从而从杂质，毒素和其他不期望的化学物质中除去 空气。 本发明的装置和方法可以容易地应用于需要空气处理的许多应用，例如家用。 此外，通过结合植物系统，该装置不仅起到功能性的作用，而且起到美学的作用。
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公开(公告)号：USD636177S1
公开(公告)日：2011-04-19
申请号：US29363655
申请日：2010-06-11
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55.再颁专利Compositions and methods for enhancing receptor-mediated cellular internalization 有权用于增强受体介导的细胞内化的组合物和方法公开(公告)号：USRE42012E1
公开(公告)日：2010-12-28
申请号：US11821512
申请日：2007-06-21
IPC分类号： A61F13/02
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译： 公开了用于改善一种或多种化合物的细胞内化的组合物和方法。 组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。 该组合物还包括或与其结合使用，其量可以有效地最大化受体的表达或结合，并增强化合物进入细胞的RME。 这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。 组合物经口，鼻，阴道，直肠和眼部局部应用。 增强剂与组合物一起施用或分开施用，全部或优选局部施用。 待递送的化合物也可以是增强剂。
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公开(公告)号：US07678364B2
公开(公告)日：2010-03-16
申请号：US09822716
申请日：2001-03-30
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K38/28
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a multivalent metal cation which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the cation upon association with the agent, a pharmaceutically acceptable carrier and optionally, a multivalent metal cation-containing component wherein the total amount of multivalent metal cation present in the particles is more than 1% weight/weight of the total weight of the agent (% w/w). Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含多价金属阳离子的颗粒，所述多价金属阳离子是 与治疗性，预防性或诊断剂或其任何组合复合，其具有能够与该药物结合时与阳离子络合的电荷，药学上可接受的载体和任选的多价金属阳离子组分，其中多价金属阳离子的总量 颗粒中存在的重量比重大于重量的1％（％w / w）。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US20080226730A1
公开(公告)日：2008-09-18
申请号：US11860302
申请日：2007-09-24
申请人： Jennifer L. Schmitke , Donghao Chen , Richard P. Batycky , David A. Edwards , Jeffrey S. Hrkach
发明人： Jennifer L. Schmitke , Donghao Chen , Richard P. Batycky , David A. Edwards , Jeffrey S. Hrkach
CPC分类号： A61K9/1617 , A61K9/0075 , A61K38/28 , A61K47/544
摘要： The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
摘要翻译： 本发明一般涉及具有包含磷脂，生物活性剂和赋形剂以及其肺部递送的颗粒的制剂。 公开了干粉吸入胰岛素制剂。 公开了包含可用于治疗糖尿病的DPPC，胰岛素和柠檬酸钠的改进制剂。 此外，本发明涉及一种用于肺部递送生物活性剂的方法，包括向需要治疗的患者的呼吸道施用或相关地诊断包含生物活性剂或其任何组合的有效量的颗粒，其中 药剂从施用的颗粒的释放以快速方式发生。
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公开(公告)号：US20080039366A1
公开(公告)日：2008-02-14
申请号：US11436404
申请日：2006-05-18
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒 药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US07266728B1
公开(公告)日：2007-09-04
申请号：US09410646
申请日：1999-10-01
IPC分类号： G06F11/00
CPC分类号： G06F11/3636 , G06F11/364 , G06F11/3648
摘要： A circuit for monitoring information put onto an interconnect by one or more modules, said circuit comprising circuitry for determining if the information on the interconnect matches one or more conditions; and circuitry for preventing a module from putting further information onto said interconnect if it is determined that information on the interconnect matches said one or more conditions.
摘要翻译： 一种用于监视由一个或多个模块放在互连上的信息的电路，所述电路包括用于确定所述互连上的信息是否匹配一个或多个条件的电路; 以及用于如果确定互连上的信息匹配所述一个或多个条件，则用于防止模块将更多信息放入所述互连的电路。
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公开(公告)号：US07182961B2
公开(公告)日：2007-02-27
申请号：US10300657
申请日：2002-11-20
IPC分类号： A61K9/50
CPC分类号： A61K9/0075 , A61K9/1694
摘要： This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (σ) is greater than 2, optimally greater than 3.
摘要翻译： 本发明涉及用于将药物递送至肺部系统的改进的颗粒组合物。 申请人公开了一种识别高分散性的空气动力学轻微颗粒的最佳形式的方法。 本发明的颗粒通过在颗粒形成过程中产生塌陷的中空的球形药物颗粒（即祖细胞颗粒）制成，导致具有非常低的包膜密度的褶皱，薄壁的药物颗粒。 此外，申请人已经发现，当表面积参数（σ）大于2，最佳大于3时，这些颗粒对于吸入的气溶胶是特别优选的。
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