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    Method of producing an air-hardenable bainite-martensite steel
    3.
    发明授权
    Method of producing an air-hardenable bainite-martensite steel 失效
    制造空气可硬化的贝氏体 - 马氏体钢的方法

    公开(公告)号：US5123970A

    公开(公告)日：1992-06-23

    申请号：US519048

    申请日：1990-05-04

    Applicant: Hongsheng Fang ,  Yankang Zheng ,  Xiuyun Chen ,  Donghao Chen ,  Rufa Zhao

    Inventor： Hongsheng Fang ,  Yankang Zheng ,  Xiuyun Chen ,  Donghao Chen ,  Rufa Zhao

    IPC: C22C38/38

    CPC classification number: C22C38/38

    Abstract: Air-hardenable steels of duplex bainite/martensite microstructure consisting essentially of 0.10 to 0.7% C, 0.1 to 2% Si, 2.1 to 3.5% Mn, 0.0005 to 0.005% B, up to 3.5% Cr and preferably containing Cr in amount of at least 0.1%, balance Fe except for incidental impurities. Optional elements are up to 1.5% W, 1.0% Mo, 0.15% V, 0.2% S, 0.1% Ca, 0.1% Pb, 0.1% Ti and 0.2% total rare earths. At least 1.0% Cr is especially preferred and if below such amount, total Mn and Si is at least 3% and in such case, if C is under 0.47%, at least 0.6% Si is present. The steels are hardenable to R.sub.c 2o to R.sub.c 58 and have a hardenable diameter in the range between 35 mm and 80 to 100 mm by air-cooling only, together with good strength, toughness and fatigue- and wear-resistance.

    Abstract translation: 双相贝氏体/马氏体组织的空气硬化钢基本上由C：0.10〜0.7％，Si：0.1〜2％，Mn：2.1〜3.5％，B：0.005〜0.005％，Cr：3.5％以下，优选含有Cr量 至少0.1％，平衡Fe，除了杂质。 可选元素可达1.5％W，1.0％Mo，0.15％V，0.2％S，0.1％Ca，0.1％Pb，0.1％Ti和0.2％总稀土。 至少1.0％的Cr是特别优选的，如果低于该量，则总Mn和Si至少为3％，在这种情况下，如果C在0.47％以下，则存在至少0.6％的Si。 钢可以硬化到Rc 2o到Rc 58，并且通过仅通过空气冷却，并且具有良好的强度，韧性和耐疲劳性和耐磨性，其可固化直径在35mm至80-100mm的范围内。

    Air-cooling duplex bainite-martensite steels
    6.
    发明授权
    Air-cooling duplex bainite-martensite steels 失效
    空冷双相贝氏体 - 马氏体钢

    公开(公告)号：US4957702A

    公开(公告)日：1990-09-18

    申请号：US283491

    申请日：1988-12-12

    Applicant: Hongsheng Fang ,  Yankang Zheng ,  Xiuyun Chen ,  Donghao Chen ,  Rufa Zhao

    Inventor： Hongsheng Fang ,  Yankang Zheng ,  Xiuyun Chen ,  Donghao Chen ,  Rufa Zhao

    IPC: C22C38/38

    CPC classification number: C22C38/38

    Abstract: Air-hardenable steels of duplex bainite/martensite microstructure consisting essentially of 0.10 to 0.7% C, 0.1 to 2% Si, 2.1 to 3.5% Mn, 0.0005 to 0.005% B, up to 3.5% Cr and preferably containing Cr in amount of at least 0.1%, balance Fe except for incidental impurities. Optional elements are up to 1.5% W, 1.0% Mo, 0.15% V, 0.2% S, 0.1% Ca, 0.1% Pb, 0.1% Ti and 0.2% total rare earths. At least 1.0% Cr is especially preferred and if below such amount, total Mn and Si is at least 3% and in such case, if C is under 0.47%, at least 0.6% Si is present. The steels are hardenable to R.sub.c 20 to R.sub.c 58 and have a hardenable diameter in the range between 35 mm and 80 to 100 mm by air-cooling only, together with good strength, toughness and fatigue- and wear-resistance.

    Abstract translation: 双相贝氏体/马氏体组织的空气硬化钢基本上由C：0.10〜0.7％，Si：0.1〜2％，Mn：2.1〜3.5％，B：0.005〜0.005％，Cr：3.5％以下，优选含有Cr量 至少0.1％，平衡Fe，除了杂质。 可选元素可达1.5％W，1.0％Mo，0.15％V，0.2％S，0.1％Ca，0.1％Pb，0.1％Ti和0.2％总稀土。 至少1.0％的Cr是特别优选的，如果低于该量，则总Mn和Si至少为3％，在这种情况下，如果C在0.47％以下，则存在至少0.6％的Si。 该钢可以硬化到Rc 20至Rc 58，并且通过仅通过空气冷却具有在35mm和80至100mm之间的范围内的可硬化直径，以及良好的强度，韧性和疲劳和耐磨性。

    Control of process humidity to produce large, porous particles
    7.
    发明授权
    Control of process humidity to produce large, porous particles 有权
    控制工艺湿度以产生大的多孔颗粒

    公开(公告)号：US07469488B2

    公开(公告)日：2008-12-30

    申请号：US10977088

    申请日：2004-10-29

    Applicant: Donghao Chen ,  Richard P. Batycky ,  Lloyd Johnston ,  Jeffrey Mintzes

    Inventor： Donghao Chen ,  Richard P. Batycky ,  Lloyd Johnston ,  Jeffrey Mintzes

    IPC: E02F5/10 ,  A01N25/02 ,  A61K9/14 ,  A05D7/00

    CPC classification number: A61K9/0075 ,  A61K9/1694 ,  Y10S514/951

    Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

    Abstract translation: 通过雾化液体进料并使液体进料与例如空气或氮气的干燥气体接触来产生具有特定空气动力特性的喷雾干燥颗粒。 干燥气体的湿度被控制为例如表示为露点，其已知产生具有特定振实密度或空气动力学直径的颗粒。 体积中值几何直径大于约5微米且振实密度小于约0.4g / cm 3的颗粒是优选的。

    PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES
    9.
    发明申请
    PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES 审中-公开
    具有快速释放特性的吸入颗粒物

    公开(公告)号：US20080227690A1

    公开(公告)日：2008-09-18

    申请号：US11860357

    申请日：2007-09-24

    Applicant: JENNIFER L. SCHMITKE ,  DONGHAO CHEN ,  RICHARD P. BATYCKY ,  DAVID A. EDWARDS ,  JEFFREY S. HRKACH

    Inventor： JENNIFER L. SCHMITKE ,  DONGHAO CHEN ,  RICHARD P. BATYCKY ,  DAVID A. EDWARDS ,  JEFFREY S. HRKACH

    IPC: A61K38/28 ,  A61P3/10

    CPC classification number: A61K9/0075 ,  A61K9/1617 ,  A61K38/28 ,  A61K47/544

    Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.

    Abstract translation: 本发明一般涉及具有包含磷脂，生物活性剂和赋形剂以及其肺部递送的颗粒的制剂。 公开了干粉吸入胰岛素制剂。 公开了包含可用于治疗糖尿病的DPPC，胰岛素和柠檬酸钠的制剂。 此外，本发明涉及一种用于肺部递送生物活性剂的方法，包括向需要治疗的患者的呼吸道施用或相关地诊断包含生物活性剂或其任何组合的有效量的颗粒，其中 药剂从施用的颗粒的释放以快速方式发生。

    PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES
    10.
    发明申请
    PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES 审中-公开
    具有快速释放特性的吸入颗粒

    公开(公告)号：US20080226730A1

    公开(公告)日：2008-09-18

    申请号：US11860302

    申请日：2007-09-24

    Applicant: Jennifer L. Schmitke ,  Donghao Chen ,  Richard P. Batycky ,  David A. Edwards ,  Jeffrey S. Hrkach

    Inventor： Jennifer L. Schmitke ,  Donghao Chen ,  Richard P. Batycky ,  David A. Edwards ,  Jeffrey S. Hrkach

    IPC: A61K9/14 ,  A61K38/28

    CPC classification number: A61K9/1617 ,  A61K9/0075 ,  A61K38/28 ,  A61K47/544

    Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.

    Abstract translation: 本发明一般涉及具有包含磷脂，生物活性剂和赋形剂以及其肺部递送的颗粒的制剂。 公开了干粉吸入胰岛素制剂。 公开了包含可用于治疗糖尿病的DPPC，胰岛素和柠檬酸钠的改进制剂。 此外，本发明涉及一种用于肺部递送生物活性剂的方法，包括向需要治疗的患者的呼吸道施用或相关地诊断包含生物活性剂或其任何组合的有效量的颗粒，其中 药剂从施用的颗粒的释放以快速方式发生。

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