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70 条记录 (耗时 0.036 秒)

    Osmotic device with delayed activation of drug delivery
    52.
    发明授权
    Osmotic device with delayed activation of drug delivery 失效
    渗透装置延迟激活药物递送

    公开(公告)号：US5312390A

    公开(公告)日：1994-05-17

    申请号：US4340

    申请日：1993-01-14

    申请人： Patrick S.-L. Wong

    发明人： Patrick S.-L. Wong

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The delivery of the agent formulation from the dispensing device, once begun, is continued over a predetermined prolonged period of time.

    摘要翻译： 本发明涉及一种流体吸收药物递送装置，其可用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。 一旦开始，药剂制剂从分配装置的输送在预定的较长时间内继续进行。

    Gastric retaining oral liquid dosage form
    58.
    发明授权
    Gastric retaining oral liquid dosage form 失效
    胃保留口服液体剂型

    公开(公告)号：US06635281B2

    公开(公告)日：2003-10-21

    申请号：US09469656

    申请日：1999-12-22

    申请人： Patrick S.-L. Wong ,  David E. Edgren

    发明人： Patrick S.-L. Wong ,  David E. Edgren

    IPC分类号： A61K926

    CPC分类号： A61K9/0065 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及适于保留在胃中并且可用于将液体活性剂制剂延长递送至使用的流体环境的活性剂剂型。 液体活性剂配方被吸收到分散在与胃液接触时膨胀的聚合物基质中的多孔颗粒中。 聚合物基质的一部分可以被不溶性材料带包围，从而防止聚合物基质的被覆盖部分膨胀，并且提供具有足够刚性以抵抗胃的收缩并延迟排出的部分的剂型 从胃直到基本上所有的活性剂已被分配的剂型。

    Oral delivery of discrete units
    59.
    发明授权
    Oral delivery of discrete units 有权
    口服离散单位

    公开(公告)号：US06333050B2

    公开(公告)日：2001-12-25

    申请号：US09764074

    申请日：2001-01-19

    申请人： Patrick S.-L. Wong ,  Howard B. Rosen ,  Nathan Roth ,  Phyllis I. Gardner

    发明人： Patrick S.-L. Wong ,  Howard B. Rosen ,  Nathan Roth ,  Phyllis I. Gardner

    IPC分类号： A61K914

    CPC分类号： A61K9/0092 ,  A47G21/183 ,  A61J7/0038

    摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.

    摘要翻译： 本发明涉及一种用于将活性剂制剂的离散单元递送至患者的口服活性剂递送系统和方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持剂的活性剂制剂室在第一端置于流体中，并在第二端置于患者口中。 当患者在房间的第二端上浸泡时，递送活性剂。