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    Prolonged release active agent dosage form adapted for gastric retention
    5.
    发明授权
    Prolonged release active agent dosage form adapted for gastric retention 失效
    延长释放活性剂剂型适合胃潴留

    公开(公告)号：US06548083B1

    公开(公告)日：2003-04-15

    申请号：US09615110

    申请日：2000-07-13

    申请人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    发明人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    IPC分类号： A61K922

    CPC分类号： A61K9/0065 ,  A61K9/2072

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及一种活性剂剂型，其适于保留在胃中并且可用于将活性剂制剂延长递送至使用的流体环境。 活性剂剂型是与胃液接触时膨胀的聚合物基质。 聚合物基质的一部分由不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并提供具有足够刚性以抵抗胃收缩和延迟排出的部分的剂型 剂型，直到基本上所有的活性剂已被分配。

    Gastric retaining oral liquid dosage form
    8.
    发明授权
    Gastric retaining oral liquid dosage form 失效
    胃保留口服液体剂型

    公开(公告)号：US06635281B2

    公开(公告)日：2003-10-21

    申请号：US09469656

    申请日：1999-12-22

    申请人： Patrick S.-L. Wong ,  David E. Edgren

    发明人： Patrick S.-L. Wong ,  David E. Edgren

    IPC分类号： A61K926

    CPC分类号： A61K9/0065 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及适于保留在胃中并且可用于将液体活性剂制剂延长递送至使用的流体环境的活性剂剂型。 液体活性剂配方被吸收到分散在与胃液接触时膨胀的聚合物基质中的多孔颗粒中。 聚合物基质的一部分可以被不溶性材料带包围，从而防止聚合物基质的被覆盖部分膨胀，并且提供具有足够刚性以抵抗胃的收缩并延迟排出的部分的剂型 从胃直到基本上所有的活性剂已被分配的剂型。