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公开(公告)号：US20170066766A1
公开(公告)日：2017-03-09
申请号：US15357195
申请日：2016-11-21
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
摘要翻译： 制备所述化合物的方法及其治疗用途。 本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。
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公开(公告)号：US20160102092A1
公开(公告)日：2016-04-14
申请号：US14972984
申请日：2015-12-17
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US20150119385A1
公开(公告)日：2015-04-30
申请号：US14522721
申请日：2014-10-24
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , A61K31/506 , C07D498/04 , A61K31/55 , A61K31/497 , A61K31/5377 , C07D519/00 , A61K31/541 , A61K31/444 , A61K31/5383
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备所述化合物的方法及其治疗用途。 本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。
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公开(公告)号：US08357707B2
公开(公告)日：2013-01-22
申请号：US12829526
申请日：2010-07-02
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D513/04 , C07D513/14
摘要： The present invention relates to compounds of formula I and salts thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如描述中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而改善的疾病中的组合物和用途。
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公开(公告)号：US20120165310A1
公开(公告)日：2012-06-28
申请号：US13394534
申请日：2010-09-10
申请人： Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
发明人： Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
IPC分类号： A61K31/519 , A61K31/541 , C07D493/08 , A61K31/5377 , A61K31/554 , A61P19/00 , A61K31/5386 , C07D495/08 , A61P35/00 , A61P11/00 , A61P1/16 , C07D487/04 , C07D487/08
CPC分类号： C07D487/04 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K9/4858
摘要： The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.
摘要翻译： 本发明涉及式I化合物，其中取代基如说明书中所定义; 制备这些化合物的方法; 包含这些化合物的药物组合物; 诸如药物的化合物; 这种化合物用于治疗增殖性疾病。
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公开(公告)号：US08193164B2
公开(公告)日：2012-06-05
申请号：US12297491
申请日：2007-04-19
IPC分类号： C07D519/00 , A61K31/52 , A61P17/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P37/08 , C07D473/40 , C07D251/54 , C07D251/50 , C07D473/16
CPC分类号： C07D519/00 , C07H19/16 , C07H21/00
摘要： A compound of formula (I), or stereoisomers or pharmaceutically acceptable salts thereof, wherein, R1a, R1b, R2a, R2b, U1, U2, X1, X2 and L are as defined herein.
摘要翻译： 式（I）化合物或其立体异构体或其药学上可接受的盐，其中R1a，R1b，R2a，R2b，U1，U2，X1，X2和L如本文所定义。
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57.发明申请公开(公告)号：US20120108555A1
公开(公告)日：2012-05-03
申请号：US13346108
申请日：2012-01-09
CPC分类号： A61K31/4704 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/47 , A61K2300/00
摘要： A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease, the molar ratio of (A) to (B) being from 100:1 to 1:300.
摘要翻译： 一种药物，其包含（A）游离或药学上可接受的盐或溶剂合物形式的式（I）化合物和（B）皮质类固醇，分别或一起用于治疗炎性或阻塞性气道的同时，连续或分开施用 疾病，（A）与（B）的摩尔比为100:1-1:300。
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公开(公告)号：US20120077838A1
公开(公告)日：2012-03-29
申请号：US13295426
申请日：2011-11-14
IPC分类号： A61K31/46 , A61P11/00 , A61P29/00 , A61K31/4704
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20110034509A1
公开(公告)日：2011-02-10
申请号：US12885922
申请日：2010-09-20
IPC分类号： A61K31/4704 , A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20100298286A1
公开(公告)日：2010-11-25
申请号：US12809642
申请日：2008-12-18
IPC分类号： A61K31/397 , C07D417/14 , A61K31/427 , A61K31/55 , A61K31/4439 , A61P35/00 , A61P35/02 , A61P11/06 , A61P17/06 , A61P17/00 , A61P7/06 , A61P29/00 , A61P9/10 , A61P9/00 , A61P19/02 , A61P27/06
CPC分类号： C07D417/14
摘要： The present invention relates to a compound of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而改善的疾病中的组合物和用途。
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