-
公开(公告)号：US08436017B2
公开(公告)日：2013-05-07
申请号：US13555536
申请日：2012-07-23
IPC分类号： A61K31/395 , A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
-
公开(公告)号：US07008951B2
公开(公告)日：2006-03-07
申请号：US10911201
申请日：2004-08-04
IPC分类号： A61K31/44 , C07D453/02 , C07D217/24
CPC分类号： A61K31/4704 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/47 , A61K2300/00
摘要： A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease, the molar ratio of (A) to (B) being from 100:1 to 1:300.
-
公开(公告)号：US06921757B2
公开(公告)日：2005-07-26
申请号：US10312021
申请日：2001-06-26
申请人： Bernard Cuenoud , David Beattie , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , David Andrew Sandham , Simon James Watson
发明人： Bernard Cuenoud , David Beattie , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , David Andrew Sandham , Simon James Watson
IPC分类号： A61K31/56 , A61P11/08 , A61P29/00 , A61P43/00 , C07C401/00 , C07J3/00 , C07J17/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J71/00 , A61K31/58
CPC分类号： C07J41/0038 , C07J3/005 , C07J17/00 , C07J33/002 , C07J41/0094 , C07J43/003 , C07J71/0015
摘要： Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals
摘要翻译： 式（I）化合物，其中R是环系中具有3至15个原子的一价环状有机基团，可用作药物
-
公开(公告)号：US5910408A
公开(公告)日：1999-06-08
申请号：US487867
申请日：1995-06-07
CPC分类号： C12N15/113 , C12N15/1034 , A61K38/00 , C12N2310/111 , C12N2310/12
摘要： The invention features nucleic acid molecules and, in particular, DNA molecules having catalytic activity, as well as methods for obtaining and using such nucleic acid molecules.
摘要翻译： 本发明的特征在于核酸分子，特别是具有催化活性的DNA分子，以及获得和使用该核酸分子的方法。
-
公开(公告)号：US20120302531A1
公开(公告)日：2012-11-29
申请号：US13555536
申请日：2012-07-23
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, whereAr is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
-
公开(公告)号：US20110105535A1
公开(公告)日：2011-05-05
申请号：US13005132
申请日：2011-01-12
申请人： Ian BRUCE , Bernard Cuenoud , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , Nicola Press , Darren Mark Le Grand , Cathy Ritchie , Barbara Valade , Judy Hayler , Emma Budd
发明人： Ian BRUCE , Bernard Cuenoud , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , Nicola Press , Darren Mark Le Grand , Cathy Ritchie , Barbara Valade , Judy Hayler , Emma Budd
IPC分类号： A61K31/506 , C07D417/14 , A61P3/04 , C07D471/04 , A61P11/00 , A61P37/08 , A61P35/00 , A61P1/00 , A61P3/10
CPC分类号： A61K31/5377 , A61K31/497 , A61K45/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase.Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3和R 4具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
-
公开(公告)号：US20100068288A1
公开(公告)日：2010-03-18
申请号：US12576444
申请日：2009-10-09
CPC分类号： A61K31/4704 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/47 , A61K2300/00
摘要： A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease, the molar ratio of (A) to (B) being from 100:1 to 1:300.
摘要翻译： 一种药物，其包含（A）游离或药学上可接受的盐或溶剂合物形式的式（I）化合物和（B）皮质类固醇，分别或一起用于治疗炎性或阻塞性气道的同时，连续或分开施用 疾病，（A）与（B）的摩尔比为100:1-1:300。
-
8.发明申请Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity 审中-公开具有β-2-肾上腺素受体激动剂活性的苯并噻唑衍生物公开(公告)号：US20060106075A1
公开(公告)日：2006-05-18
申请号：US10522359
申请日：2003-08-08
申请人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
发明人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
IPC分类号： A61K31/428 , C07D277/68
CPC分类号： C07D417/12 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D277/68
摘要： Compounds of formula (I) in free or salt or solvate form, wherein X has the meaning indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中X具有说明书中指出的含义，可用于治疗通过β2 - 肾上腺素受体激活而预防或缓解的病症。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
-
公开(公告)号：US20050159374A1
公开(公告)日：2005-07-21
申请号：US10696488
申请日：2003-10-29
CPC分类号： C07H21/00
摘要： The invention relates to an oligonucleotide derivative which comprises at least one nucleoside building block of the formula (I) The invention furthermore relates to nucleoside building blocks, intermediates and processes for preparing the oligonucleotide derivatives and the nucleoside building blocks. The invention also relates to pharmaceutical compositions and to uses of the oligonucleotide derivatives and the nucleoside building blocks.
摘要翻译： 本发明涉及包含至少一种式（I）核苷结构单元的寡核苷酸衍生物。本发明还涉及核苷结构单元，中间体和制备寡核苷酸衍生物和核苷结构单元的方法。 本发明还涉及药物组合物以及寡核苷酸衍生物和核苷结构单元的用途。
-
公开(公告)号：US20050153957A1
公开(公告)日：2005-07-14
申请号：US11074400
申请日：2005-03-07
申请人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
IPC分类号： A61K31/137 , A61K31/167 , A61K31/18 , A61K31/222 , A61K31/4704 , A61P11/00 , A61P11/02 , A61P15/06 , A61P25/02 , A61P37/00 , A61P37/08 , A61P43/00 , C07C211/38 , C07C211/42 , C07C215/76 , C07C215/80 , C07C233/03 , C07C233/43 , C07C311/03 , C07C311/08 , C07D215/22 , C07D215/227 , C07D215/26 , C07D405/12 , A61K31/542 , A61K31/423 , A61K31/428 , A61K31/4706 , A61K31/538
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 游离或盐或溶剂合物形式的化合物，其中Ar是式Y基团是碳或氮，R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， R 0，R 9，R 10，X，n，p，q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是 治疗阻塞性或炎症性气道疾病。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.027 秒)
