公开(公告)号：US20190062335A1

公开(公告)日：2019-02-28

申请号：US16002116

申请日：2018-06-07

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Karsten Juhl ,  Paulo Jorge Vieira Vital

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US10011606B2

公开(公告)日：2018-07-03

申请号：US15615380

申请日：2017-06-06

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US20180179200A1

公开(公告)日：2018-06-28

申请号：US15849798

申请日：2017-12-21

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgard ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC: C07D471/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16 ,  A61P25/00

CPC classification number: C07D471/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US09861639B2

公开(公告)日：2018-01-09

申请号：US15415073

申请日：2017-01-25

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC: A61K31/553 ,  A61K31/5377 ,  A61K31/5375 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/40 ,  A61K31/506 ,  A61K31/454 ,  A61K31/4453

CPC classification number: A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

公开(公告)号：US20170202836A1

公开(公告)日：2017-07-20

申请号：US15479972

申请日：2017-04-05

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang ,  Allen T. Hopper

IPC: A61K31/505

CPC classification number: A61K31/505 ,  C07C233/66 ,  C07C233/73 ,  C07C233/75 ,  C07C233/78 ,  C07C2601/08 ,  C07D211/26 ,  C07D213/40 ,  C07D213/61 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D309/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06

Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.

公开(公告)号：US20170008898A1

公开(公告)日：2017-01-12

申请号：US15205850

申请日：2016-07-08

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC: C07D487/04 ,  C07D295/13 ,  C07D403/06 ,  C07D401/06 ,  C07D239/26 ,  C07D213/38 ,  C07D211/38

CPC classification number: A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

Abstract translation: 本发明涉及抑制P2X7受体的新型环胺。

公开(公告)号：US20160318939A1

公开(公告)日：2016-11-03

申请号：US15142116

申请日：2016-04-29

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract translation: 本发明提供作为PDE1抑制剂的咪唑并吡嗪酮及其作为药物的用途，特别是用于治疗神经变性疾病和精神障碍。

公开(公告)号：US20160311831A1

公开(公告)日：2016-10-27

申请号：US15133715

申请日：2016-04-20

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides imidazotriazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract translation: 本发明提供作为PDE1抑制剂的咪唑并三氮嗪酮及其作为药物的用途，特别是用于治疗神经变性疾病和精神障碍。

公开(公告)号：US09415055B2

公开(公告)日：2016-08-16

申请号：US14793773

申请日：2015-07-08

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC: A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/4545 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/553 ,  A61K31/625 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D209/52

CPC classification number: A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

公开(公告)号：US20150283134A1

公开(公告)日：2015-10-08

申请号：US14744103

申请日：2015-06-19

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang ,  Allen T. Hopper

IPC: A61K31/505

CPC classification number: A61K31/505 ,  C07C233/66 ,  C07C233/73 ,  C07C233/75 ,  C07C233/78 ,  C07C2601/08 ,  C07D211/26 ,  C07D213/40 ,  C07D213/61 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D309/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06

Abstract: The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor

Abstract translation: 本发明涉及抑制P2X7受体的含苯甲酰胺的化合物