公开(公告)号：US20170266224A1

公开(公告)日：2017-09-21

申请号：US15610692

申请日：2017-06-01

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： James L. Hedrick ,  lchiyama Koji ,  Naoki Yamamoto ,  Chuan Yang ,  Yi Yan Yang

IPC: A61K31/785 ,  C08G73/02 ,  C12N7/00

CPC classification number: A61K31/785 ,  C08G73/0206 ,  C08G73/0233 ,  C12N7/00 ,  C12N2710/10363 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2770/20063 ,  C12N2770/24163 ,  C12N2770/32363 ,  C12N2770/36163 ,  Y02A50/382 ,  Y02A50/385

Abstract: Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.

公开(公告)号：US09682100B2

公开(公告)日：2017-06-20

申请号：US14605228

申请日：2015-01-26

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： James L. Hedrick ,  Ichiyama Koji ,  Naoki Yamamoto ,  Chuan Yang ,  Yi Yan Yang

IPC: A61K31/785 ,  C08G73/02 ,  C12N7/00

CPC classification number: A61K31/785 ,  C08G73/0206 ,  C08G73/0233 ,  C12N7/00 ,  C12N2710/10363 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2770/20063 ,  C12N2770/24163 ,  C12N2770/32363 ,  C12N2770/36163 ,  Y02A50/385

Abstract: Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.

公开(公告)号：US20170056513A1

公开(公告)日：2017-03-02

申请号：US14836614

申请日：2015-08-26

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： James Hedrick ,  Dylan BODAY ,  Jeannette GARCIA ,  Rudy WOJTECKI ,  Yi Yan YANG ,  Chuan Yang

IPC: A61K47/48 ,  A61K48/00 ,  A61K31/713

CPC classification number: A61K47/48192 ,  A61K31/7088 ,  A61K47/59 ,  C12N15/87

Abstract: The disclosure describes methods and therapeutic compositions comprising polymers modified with N-alkyl-hydroxy groups comprising one or more carbon atoms. The compositions are useful for gene delivery, and exhibit broad-spectrum antiviral activity and low toxicity in vitro.

Abstract translation: 本公开描述了包含用包含一个或多个碳原子的N-烷基 - 羟基改性的聚合物的方法和治疗组合物。 该组合物可用于基因递送，并且在体外表现出广谱抗病毒活性和低毒性。

公开(公告)号：US20140297589A1

公开(公告)日：2014-10-02

申请号：US13852571

申请日：2013-03-28

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Danny Y. Chen ,  Fabian F. Morgan ,  Sarah V. White Eagle ,  Chuan Yang ,  Dan Dan Zheng

IPC: G06F17/30

CPC classification number: G06F17/30174 ,  G06F17/30 ,  G06F17/30581 ,  H04L67/1095

Abstract: An approach is provided for synchronizing elements in files across a technical environment. In one embodiment, a processor obtains a first change to a first file. The processor also obtains data identifying a second file. The processor determines if the change is supported by a data library in a pre-defined list of data sources. The processor analyzes the data library to determine a type of the change. The processor applies the type of the change to the second file.

Abstract translation: 提供了一种在技术环境中同步文件中的元素的方法。 在一个实施例中，处理器获得对第一文件的第一改变。 处理器还获得识别第二文件的数据。 处理器确定数据库中预定义的数据源列表中数据库是否支持更改。 处理器分析数据库以确定更改的类型。 处理器将更改的类型应用于第二个文件。