公开(公告)号：US20110172284A1

公开(公告)日：2011-07-14

申请号：US13058653

申请日：2009-08-13

申请人： Sergey V. Paushkin ,  Nikolai A. Naryshkin ,  Ellen Welch

发明人： Sergey V. Paushkin ,  Nikolai A. Naryshkin ,  Ellen Welch

IPC分类号： A61K31/4035 ,  C12Q1/68 ,  A61P43/00

CPC分类号： A61K31/4035 ,  C12N7/00 ,  C12N15/11 ,  C12N2710/16663 ,  C12N2720/00063 ,  C12N2740/11063 ,  C12N2740/12063 ,  C12N2740/14063 ,  C12N2740/15063 ,  C12N2740/16063 ,  C12N2770/00063 ,  C12N2770/10063 ,  C12N2770/12063 ,  C12N2770/20063 ,  C12N2770/38063 ,  C12N2795/10263 ,  C12N2795/10363 ,  C12Q1/66 ,  C12Q1/6897 ,  Y02A50/491

摘要： Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of said compounds to produce a stabilized SMNΔEx7 protein and treat Spinal Muscular Atrophy.

摘要翻译： 本文描述了用于鉴定或验证能够引起核糖体移码的化合物的方法，以及使用所述化合物产生稳定的SMN＆Dgr; Ex7蛋白并治疗脊髓性肌肉萎缩的方法。

公开(公告)号：US20240226270A1

公开(公告)日：2024-07-11

申请号：US17177724

申请日：2021-02-17

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia PIaja Dilmé ,  Alicia URNIZA Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/12 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K39/12 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US09950061B2

公开(公告)日：2018-04-24

申请号：US14672631

申请日：2015-03-30

申请人： Boehringer Ingelheim Vetmedica, Inc.

发明人： Luis Alejandro Hernandez ,  Arun V. Iyer ,  Dianna M. Murphy Jordan ,  Abby Rae Patterson ,  Michael B. Roof ,  Eric Martin Vaughn ,  Joseph Gilbert Victoria

IPC分类号： A61K39/215 ,  A61K45/06 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/215 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063

摘要： The present invention relates to a vaccine for protecting a pig against diseases associated with porcine epidemic diarrhea virus. The vaccine commonly includes inactivated/killed PEDV (e.g., chemically inactivated PED virus), and/or recombinant PEDV antigen and an adjuvant. Methods for protecting pigs against diseases associated with PEDV and methods of producing the porcine epidemic diarrhea virus vaccine are also provided.

公开(公告)号：US08932818B2

公开(公告)日：2015-01-13

申请号：US13058613

申请日：2009-08-13

申请人： Sergey V. Paushkin ,  Nikolai A. Naryshkin ,  Ellen Welch

发明人： Sergey V. Paushkin ,  Nikolai A. Naryshkin ,  Ellen Welch

IPC分类号： C12Q1/68 ,  C12Q1/66 ,  C12Q1/48 ,  C12Q1/34 ,  C12Q1/02

CPC分类号： A61K31/4035 ,  C12N7/00 ,  C12N15/11 ,  C12N2710/16663 ,  C12N2720/00063 ,  C12N2740/11063 ,  C12N2740/12063 ,  C12N2740/14063 ,  C12N2740/15063 ,  C12N2740/16063 ,  C12N2770/00063 ,  C12N2770/10063 ,  C12N2770/12063 ,  C12N2770/20063 ,  C12N2770/38063 ,  C12N2795/10263 ,  C12N2795/10363 ,  C12Q1/66 ,  C12Q1/6897 ,  Y02A50/491

摘要： The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal frameshifting. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of compounds that modulate the efficiency of programmed ribosomal frameshifting to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting.

摘要翻译： 本发明涉及调节核糖体移码和核酸构建体的化合物，其用于鉴定或验证调节核糖体移码的化合物的方法。 特别地，本发明涉及核酸构建体用于鉴定或验证能够调节编程的核糖体移码效率的化合物的用途，以及调节编程的核糖体移码效率以抑制病毒的复制或感染性的化合物的用途， 采用编程的核糖体移码。

公开(公告)号：US20240293531A1

公开(公告)日：2024-09-05

申请号：US17913638

申请日：2021-04-06

申请人： Valneva Austria GmbH

发明人： Andreas Meinke ,  Michael Möhlen ,  Robert Schlegl ,  Jürgen Heindl-Wruss

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/575 ,  C12N2770/20034 ,  C12N2770/20063

摘要： Described herein are SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

公开(公告)号：US20190216919A1

公开(公告)日：2019-07-18

申请号：US16282953

申请日：2019-02-22

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia Plaja Dilme ,  Alicia Urniza Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  C12N7/00 ,  A61K39/12

CPC分类号： A61K39/215 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US20060257852A1

公开(公告)日：2006-11-16

申请号：US10822303

申请日：2004-04-09

申请人： Rino Rappuoli ,  Vega Masignani ,  Konrad Stadler ,  Jens Gregersen ,  David Chien ,  Jang Han ,  John Polo ,  Amy Weiner ,  Michael Houghton ,  Hyun Song ,  Mi-Young Seo ,  John Donnelly ,  Hans Klenk ,  Nicholas Valiante

发明人： Rino Rappuoli ,  Vega Masignani ,  Konrad Stadler ,  Jens Gregersen ,  David Chien ,  Jang Han ,  John Polo ,  Amy Weiner ,  Michael Houghton ,  Hyun Song ,  Mi-Young Seo ,  John Donnelly ,  Hans Klenk ,  Nicholas Valiante

IPC分类号： C12Q1/70 ,  C07H21/04 ,  C12N15/86 ,  C07K14/165

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55566 ,  C07K16/10 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/21 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2770/20051 ,  C12N2770/20063 ,  C12Q1/701 ,  G01N2333/165 ,  G01N2469/20

摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.

摘要翻译： 在2003年，中国香港和世界各地越来越多的国家确定了现在称为严重急性呼吸综合征（SARS）的毒性呼吸道病毒的爆发。本发明涉及SARS冠状病毒的核酸和蛋白质 。 这些核酸和蛋白质可用于制备和制造疫苗制剂，诊断试剂，试剂盒等。本发明还提供了通过施用小分子抗病毒化合物治疗SARS的方法，以及鉴定用于治疗SARS的有效小分子的方法 治疗SARS。

公开(公告)号：US11643641B2

公开(公告)日：2023-05-09

申请号：US17681206

申请日：2022-02-25

申请人： Malireddy S. Reddy

发明人： Malireddy S. Reddy

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N2770/20063

摘要： A method and composition for inactivating both naked genetic material such as RNA and DNA and inactivating mechanical delivery vectors in a treatment space external of the human body. To practice the method, apply a mist of lipid molecule degrading agent effective against viral membranes with lipid molecules. Then apply an inactivator of spike proteins and other viral residues. Next, reduce the threat of transmitting genetic material by applying inactivators of mechanical transport vectors such as mold, yeast, and bacteria. Further, pretreat the treating space to receive enzymatic agents by applying a surface detoxifying agent in quantity sufficient to inactivate substances detrimental to enzymes that break the naked viral genetic material. Then, apply preparatory enzymes that degrade microorganisms and their cellular components. Finally, apply enzymes for breaking the naked viral genetic material, as present.

公开(公告)号：US20170340729A1

公开(公告)日：2017-11-30

申请号：US15672019

申请日：2017-08-08

申请人： MJ Biologics, Inc. ,  Phibro Animal Health Corporation

发明人： Byoung-Kwan Kim ,  Karen Brown ,  Larry Miller

IPC分类号： A61K39/215 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/215 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/20063

摘要： Disclosed herein are embodiments of an immunogenic composition for porcine epidemic diarrhea virus, and a method for making the immunogenic composition. Also disclosed is a method for administrating the immunogenic composition to a subject in need thereof. The immunogenic composition comprises PEDV proteins and/or antigens from one or more strains of PEDV, and may additionally comprise proteins and/or antigens from one or more additional porcine pathogens, such as PRRSV. Additionally disclosed in a combination comprising a PEDV immunogenic composition as disclosed herein, and an immunogenic composition or other therapeutic composition directed toward an additional porcine pathogen.

公开(公告)号：US20160213707A1

公开(公告)日：2016-07-28

申请号：US14605228

申请日：2015-01-26

申请人： International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

发明人： James L. Hedrick ,  Ichiyama Koji ,  Naoki Yamamoto ,  Chuan Yang ,  Yi Yan Yang

IPC分类号： A61K31/785 ,  C08G73/02 ,  C12N7/00

CPC分类号： A61K31/785 ,  C08G73/0206 ,  C08G73/0233 ,  C12N7/00 ,  C12N2710/10363 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2770/20063 ,  C12N2770/24163 ,  C12N2770/32363 ,  C12N2770/36163 ,  Y02A50/385

摘要： Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.

摘要翻译： 通过用引入包含一个或多个碳和至少一个醇羟基的侧链的N-酰化剂改性聚乙烯亚胺制备抗病毒阳离子多胺。 阳离子多胺可以具有直链或支链的聚乙烯亚胺骨架结构。 优选地，阳离子多胺包括侧链单糖基团，其可以通过包含侧基保护的单糖（例如甘露糖）基团的环状碳酸酯引入。 阳离子多胺可以对低浓度的广谱病毒具有活性和选择性，并且通常是无毒的。