公开(公告)号：US20210299160A1

公开(公告)日：2021-09-30

申请号：US16832452

申请日：2020-03-27

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Jiayu Leong ,  Chuan Yang ,  Xin Ding ,  Yiran Zhen ,  Cherylette Anne Alexander ,  Jye Yng Teo

IPC: A61K31/785

Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.

公开(公告)号：US11116844B2

公开(公告)日：2021-09-14

申请号：US16577142

申请日：2019-09-20

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： Dylan Boday ,  Wei Cheng ,  Jeannette M. Garcia ,  James Hedrick ,  Nathaniel H. Park ,  Rudy J. Wojtecki ,  Chuan Yang ,  YiYan Yang

IPC: A61K47/60 ,  A61K47/69 ,  A61K31/785 ,  A61P35/00 ,  C08G65/332 ,  C08G65/00 ,  C08L71/02 ,  C08G64/18 ,  C08L71/00 ,  A61K9/107

Abstract: Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.

公开(公告)号：US11028264B2

公开(公告)日：2021-06-08

申请号：US16531432

申请日：2019-08-05

Applicant: International Business Machines Corporation ,  Agency For Science, Technology And Research

Inventor： Nathaniel H. Park ,  James L. Hedrick ,  Victoria A. Piunova ,  Gavin Jones ,  Yi Yan Yang ,  Pang Kern Jeremy Tan ,  Chuan Yang ,  Cherylette Anne Alexander

IPC: A61K45/06 ,  C08L79/02

Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

公开(公告)号：US20210121498A1

公开(公告)日：2021-04-29

申请号：US17136709

申请日：2020-12-29

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Simone Bianco ,  Mark Kunitomi ,  Yi Yan Yang ,  Xin Ding ,  Chuan Yang ,  Zhen Chang Liang ,  Paola Florez de Sessions ,  Balamurugan Periaswamy

IPC: A61K31/785 ,  A61P31/04

Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

公开(公告)号：US20210038635A1

公开(公告)日：2021-02-11

申请号：US16531493

申请日：2019-08-05

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Xin Ding ,  Chuan Yang

IPC: A61K31/765 ,  A61K33/242

Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

公开(公告)号：US10667514B2

公开(公告)日：2020-06-02

申请号：US15839415

申请日：2017-12-12

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： Mareva B. Fevre ,  James L. Hedrick ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Pang Kern Jeremy Tan ,  Chuan Yang ,  Yi Yan Yang

IPC: A01N25/04 ,  A01N25/10 ,  A01N27/00 ,  A01N33/04 ,  A01N43/08 ,  A01N47/30 ,  A01N37/02 ,  A01N33/12 ,  A61Q17/00

Abstract: Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.

公开(公告)号：US09987369B2

公开(公告)日：2018-06-05

申请号：US15340795

申请日：2016-11-01

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wei Cheng ,  Mareva B. Fevre ,  James L. Hedrick ,  Nor Lizawati Ibrahim ,  Ashlynn L. Z. Lee ,  Victor W. L. Ng ,  Robert J. Ono ,  Chuan Yang ,  Yi Yan Yang

IPC: A61K39/395 ,  A61K31/65 ,  A61K31/4196 ,  A61K45/06 ,  A61K9/00 ,  A61K9/06 ,  A61K31/592 ,  A61K31/355 ,  C08G64/18 ,  C07K16/32 ,  A61K47/48 ,  A61K31/455

CPC classification number: A61K47/6903 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/355 ,  A61K31/4196 ,  A61K31/455 ,  A61K31/592 ,  A61K31/65 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/22 ,  A61K47/34 ,  A61K47/48192 ,  A61K47/48784 ,  A61K47/59 ,  C07K16/32 ,  C08G64/183 ,  C08G2210/00

Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

公开(公告)号：US20180117162A1

公开(公告)日：2018-05-03

申请号：US15340795

申请日：2016-11-01

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wei Cheng ,  Mareva B. Fevre ,  James L. Hedrick ,  Nor Lizawati Ibrahim ,  Ashlynn L.Z. Lee ,  Victor W.L. Ng ,  Robert J. Ono ,  Chuan Yang ,  Yi Yan Yang

IPC: A61K47/48 ,  A61K31/355 ,  A61K31/592 ,  A61K9/06 ,  C07K16/32 ,  A61K9/00 ,  A61K39/395 ,  A61K45/06 ,  A61K31/4196 ,  A61K31/65 ,  C08G64/18 ,  A61K31/455

CPC classification number: A61K47/6903 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/355 ,  A61K31/4196 ,  A61K31/455 ,  A61K31/592 ,  A61K31/65 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/22 ,  A61K47/34 ,  A61K47/48192 ,  A61K47/48784 ,  A61K47/59 ,  C07K16/32 ,  C08G64/183 ,  C08G2210/00

Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

公开(公告)号：US20150005457A1

公开(公告)日：2015-01-01

申请号：US13927228

申请日：2013-06-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Xin Ding ,  James L. Hedrick ,  Chuan Yang ,  Yi Yan Yang

IPC: C08G77/388 ,  C08J7/02 ,  C08J7/06 ,  A61F5/44

CPC classification number: C08G77/388 ,  A61F5/44 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  C08J7/047 ,  C08J2383/08 ,  C08J2469/00 ,  C09D183/08 ,  C08L83/04 ,  C08L69/00

Abstract: An antimicrobial silicone rubber comprises a silicone rubber substrate, a catechol layer bound to a surface of the silicone rubber substrate, and an antimicrobial layer disposed on the catechol layer. The catechol layer comprises a catechol material, a quinone derivative thereof, and/or a polymer of the foregoing catechol material and/or quinone derivative. The antimicrobial layer comprises an antimicrobial cationic polycarbonate covalently linked to the catechol layer.

Abstract translation: 抗微生物硅橡胶包括硅橡胶基材，与硅橡胶基材的表面结合的儿茶酚层和设置在儿茶酚层上的抗微生物层。 儿茶酚层包括邻苯二酚材料，其醌衍生物和/或上述儿茶酚原料和/或醌衍生物的聚合物。 抗微生物层包含共价连接到儿茶酚层的抗微生物阳离子聚碳酸酯。

公开(公告)号：US12059431B2

公开(公告)日：2024-08-13

申请号：US17659183

申请日：2022-04-14

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Jiayu Leong ,  Chuan Yang ,  Xin Ding ,  Yiran Zhen ,  Cherylette Anne Alexander ,  Jye Yng Teo

IPC: A61K31/785

CPC classification number: A61K31/785

Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.