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    Human Antibodies Interacting with Hiv Gp41
    54.
    发明申请
    Human Antibodies Interacting with Hiv Gp41 有权
    人类抗体与HIF Gp41相互作用

    公开(公告)号：US20070248613A1

    公开(公告)日：2007-10-25

    申请号：US11628164

    申请日：2005-05-31

    申请人： John Shiver ,  Michael Miller ,  Romas Geleziunas ,  Daria Hazuda ,  Peter Kim ,  Debra Eckert ,  Michael Root ,  Simon Lennard ,  Elisabetta Bianchi

    发明人： John Shiver ,  Michael Miller ,  Romas Geleziunas ,  Daria Hazuda ,  Peter Kim ,  Debra Eckert ,  Michael Root ,  Simon Lennard ,  Elisabetta Bianchi

    IPC分类号： A61K39/395 ,  A61K33/00 ,  A61P31/18 ,  C07H21/04 ,  C07K16/00 ,  C12N15/00 ,  C12P21/06 ,  G01N33/566

    CPC分类号： G01N33/56988 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  G01N2500/00

    摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as VH and VL chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.

    摘要翻译： 披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹，N-螺旋卷曲螺旋结构与构象表位相互作用。 显示出这些抗体以及IgG转化中和多种HIV分离物。 还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段的纯化形式，例如V H H和V L >链。 在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。 这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

    METHOD FOR CHARGING FOR A SERVICE IN A TELECOMMUNICATIONS/DATA NETWORK
    55.
    发明申请
    METHOD FOR CHARGING FOR A SERVICE IN A TELECOMMUNICATIONS/DATA NETWORK 审中-公开
    用于在电信/数据网络中为服务充电的方法

    公开(公告)号：US20070232264A1

    公开(公告)日：2007-10-04

    申请号：US11759109

    申请日：2007-06-06

    申请人： Frank Burghardt ,  Georg Kastelewicz ,  Peter Kim ,  Martin Kissner

    发明人： Frank Burghardt ,  Georg Kastelewicz ,  Peter Kim ,  Martin Kissner

    IPC分类号： H04M11/00

    CPC分类号： H04L12/1439 ,  H04L12/14 ,  H04L12/1457 ,  H04L41/5041 ,  H04L41/509

    摘要： A method for charging for a service in a telecommunications/data network, in particular UMTS mobile radio network, transactions which relate to debits being transmitted to a debiting system on network elements which implement a debiting interface, by means of an adapted transmission protocol, a hot-billing protocol which supports a termination message of the debiting system being used as the transmission protocol, a network element which is involved in the debiting transaction transmitting a message to the debiting system both at the start and at the end of the service and the service being timed in the debiting system in parallel with the execution of the service and debiting being carried out in response to the measurement result.

    摘要翻译： 一种用于对电信/数据网络，特别是UMTS移动无线电网络中的服务进行计费的方法，涉及借助于适配的传输协议将实际借用接口的网元上的借记信息发送到借记系统的事务， 支持用作传输协议的借记系统的终止消息的热计费协议，涉及在服务的开始和结束时将消息发送到记账系统的借记交易的网络元件，以及 服务在记账系统中定时并行执行服务，并根据测量结果进行借记。

    Accelerated establishment of a connection between a number of mobile radio users
    56.
    发明申请
    Accelerated establishment of a connection between a number of mobile radio users 审中-公开
    加速建立多个移动无线电用户之间的连接

    公开(公告)号：US20070183372A1

    公开(公告)日：2007-08-09

    申请号：US10564517

    申请日：2004-07-16

    申请人： Otto Janko ,  Olaf Kautz ,  Gerhard Kieselmann ,  Peter Kim ,  Ralf Munninghoff ,  Roland Steiner

    发明人： Otto Janko ,  Olaf Kautz ,  Gerhard Kieselmann ,  Peter Kim ,  Ralf Munninghoff ,  Roland Steiner

    IPC分类号： H04B7/216

    CPC分类号： H04W84/08

    摘要： Disclosed is a method which allows for a fast and efficient establishment of a connection between members of a group, more specifically between a mobile radio user who triggers the establishment of the connection and additional mobile radio users of a group of mobile radio users via at least one mobile radio network. According to the inventive method, a first channel that can be used for transmitting signaling data is set up when establishing the connection. User data, such as language, which is to be transmitted between the mobile radio user triggering the establishment of the connection and other members of the group is also transmitted via said channel in addition to the signaling data until a second channel is also set up for the connection, whereupon user data is transmitted via the second channel.

    摘要翻译： 公开了一种方法，其允许快速且有效地建立组的成员之间的连接，更具体地，在至少触发建立连接的移动无线电用户和一组移动无线电用户的附加移动无线电用户之间 一个移动无线网络。 根据本发明的方法，在建立连接时建立可用于发送信令数据的第一信道。 在触发建立连接的移动无线电用户和该组的其他成员之间将要发送的用户数据，例如除了信令数据之外，还经由所述信道被发送，直到第二信道也被设置为 连接，从而通过第二通道发送用户数据。