公开(公告)号：US08532352B2

公开(公告)日：2013-09-10

申请号：US13267662

申请日：2011-10-06

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Bogdan Georgescu ,  Yefeng Zheng ,  Jan Boese ,  Klaus Klingenbeck ,  Dorin Comaniciu

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Bogdan Georgescu ,  Yefeng Zheng ,  Jan Boese ,  Klaus Klingenbeck ,  Dorin Comaniciu

IPC分类号： G06K9/00

CPC分类号： G06T19/006 ,  G06T7/344 ,  G06T17/00 ,  G06T2207/10072 ,  G06T2207/10121 ,  G06T2207/10136 ,  G06T2207/30048 ,  G16H50/50

摘要： A method and system for intraoperative guidance in an off-pump mitral valve repair procedure is disclosed. A plurality of patient-specific models of the mitral valve are generated, each from pre-operative image data obtained using a separate imaging modality. The pre-operative image data from the separate imaging modalities are fused into a common coordinate system by registering the plurality of patient-specific models. A model of the mitral valve is estimated in real-time in intraoperative image data using a fused physiological prior resulting from the registering of the plurality of patient-specific models.

摘要翻译： 公开了一种用于非抽血二尖瓣修复手术中术中引导的方法和系统。 产生多个患者特异性二尖瓣模型，每个来自使用单独成像模态获得的术前图像数据。 来自分开的成像模态的手术前图像数据通过登记多个患者特定模型而融合到公共坐标系中。 使用由多个患者特定模型的登记产生的融合生理学先验在实际的术中图像数据中估计二尖瓣的模型。

公开(公告)号：US20130129174A1

公开(公告)日：2013-05-23

申请号：US13683224

申请日：2012-11-21

申请人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Matthias John ,  Jan Boese ,  Christian Gesell ,  Dorin Comaniciu

发明人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Matthias John ,  Jan Boese ,  Christian Gesell ,  Dorin Comaniciu

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T7/344 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/10121 ,  G06T2207/20081 ,  G06T2207/20221 ,  G06T2207/30048 ,  G06T2207/30061 ,  G06T2207/30101

摘要： A method and system for model-based fusion of multi-modal volumetric images is disclosed. A first patient-specific model of an anchor anatomical structure is detected in a first medical image acquired using a first imaging modality, and a second patient-specific model of the anchor anatomical structure is detected in a second medical image acquired using a second imaging modality. A weighted mapping function is determined based on the first patient-specific model of the anchor anatomical structure and the second patient-specific model of the anchor anatomical structure using learned weights to minimize mapping error with respect to a target anatomical structure. The target anatomical structure from the first medical image to the second medical image using the weighted mapping function. In an application of this model-based fusion to transcatheter valve therapies, the trachea bifurcation is used as the anchor anatomical structure and the aortic valve is the target anatomical structure.

摘要翻译： 公开了一种用于多模态体积图像的基于模型融合的方法和系统。 在使用第一成像模态获取的第一医疗图像中检测锚固解剖结构的第一患者特定模型，并且在使用第二成像模态获取的第二医疗图像中检测锚固解剖结构的第二患者特定模型 。 基于锚解剖结构的第一患者特定模型和使用学习权重的锚定解剖结构的第二患者特定模型来确定加权映射函数，以使关于目标解剖结构的映射误差最小化。 使用加权映射函数从第一医学图像到第二医学图像的目标解剖结构。 在这种基于模型的融合对经导管瓣膜治疗的应用中，气管分叉用作锚固解剖结构，主动脉瓣是目标解剖结构。

公开(公告)号：US08422753B2

公开(公告)日：2013-04-16

申请号：US12901600

申请日：2010-10-11

申请人： Yefeng Zheng ,  David Liu ,  Jan Boese ,  Dorin Comaniciu

发明人： Yefeng Zheng ,  David Liu ,  Jan Boese ,  Dorin Comaniciu

IPC分类号： G06K9/00 ,  G06K9/34

CPC分类号： G06T7/77 ,  G06T7/12 ,  G06T7/143 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/20081 ,  G06T2207/20124 ,  G06T2207/30048

摘要： A method and system for automatic extraction of personalized left atrium models is disclosed. A left atrium chamber body is segmented from a 3D image volume. At least one pulmonary venous ostium is detected on the segmented left atrium chamber body. At least one pulmonary vein trunk connected to the left atrium chamber body is segmented based on the detected pulmonary venous ostia.

摘要翻译： 公开了一种用于自动提取个性化左心房模型的方法和系统。 左心房腔体从3D图像体积分割。 在分割的左心房腔体上检测到至少一个肺静脉口。 基于检测到的肺静脉口，将连接到左心房腔体的至少一个肺静脉干线分段。

公开(公告)号：US08353851B2

公开(公告)日：2013-01-15

申请号：US11453611

申请日：2006-06-15

申请人： Jan Boese ,  Reinmar Killmann

发明人： Jan Boese ,  Reinmar Killmann

IPC分类号： A61B5/103 ,  A61B5/117

CPC分类号： A61B90/10 ,  A61B34/73 ,  A61B90/00 ,  A61B2017/00243 ,  A61B2017/00362 ,  A61B2017/3445

摘要： The invention relates to an apparatus for automatic replacement of instruments during minimally invasive procedures, comprising a housing, an outlet element for an instrument, a selection unit and a guide element.

摘要翻译： 本发明涉及一种在微创手术过程中自动更换仪器的装置，包括一个外壳，一个仪器出口元件，一个选择单元和一个导向元件。

公开(公告)号：US20120307964A1

公开(公告)日：2012-12-06

申请号：US13484311

申请日：2012-05-31

申请人： Andrew F. Hall ,  Jan Boese

发明人： Andrew F. Hall ,  Jan Boese

IPC分类号： A61B6/03

CPC分类号： A61B6/481 ,  A61B6/03 ,  A61B6/503 ,  A61B6/504 ,  A61B6/541

摘要： A system acquires images in the presence of a contrast agent of relatively long persistence using a synchronization processor, image acquisition device and imaging controller. The synchronization processor provides an image acquisition trigger signal for acquiring images at a particular point within both a cardiac and a respiratory cycle in response to signals representing cardiac and respiratory cycles. The image acquisition device includes an assembly comprising a radiation emitter and detector rotatable about a patient for acquiring images of a portion of patient anatomy at different angles. The imaging controller initiates acquisition of data representing multiple images in the presence of a contrast agent of relatively long persistence by repetitively, initiating rotation of the assembly to an angle, acquiring an image at the angle in response to the trigger signal and incrementally increasing the angle.

摘要翻译： 系统使用同步处理器，图像获取装置和成像控制器在存在具有较长持久性的造影剂的情况下获取图像。 同步处理器响应于表示心脏和呼吸周期的信号，提供用于在心脏和呼吸周期内的特定点获取图像的图像采集触发信号。 图像采集装置包括一个组件，该组件包括辐射发射器和围绕患者旋转的检测器，用于以不同的角度获取患者解剖结构的一部分的图像。 成像控制器在存在持续时间相对较长的造影剂的情况下启动表示多个图像的数据，重复地启动组件的旋转角度，响应于触发信号以角度获取图像并递增地增加角度 。

公开(公告)号：US08099155B2

公开(公告)日：2012-01-17

申请号：US12229332

申请日：2008-08-21

申请人： Jan Boese ,  Estelle Camus ,  Matthias John

发明人： Jan Boese ,  Estelle Camus ,  Matthias John

IPC分类号： A61B5/00

CPC分类号： A61B8/00 ,  A61B6/4441 ,  A61B6/464 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/483 ,  A61B17/3403 ,  A61B90/37 ,  A61B2017/00694 ,  A61B2017/3413 ,  A61B2090/364 ,  A61B2090/365 ,  A61B2090/367 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/378 ,  G06T7/38 ,  G06T2207/10081 ,  G06T2207/10132 ,  G06T2207/20221 ,  G06T2207/30056

摘要： The present invention relates to a method for assisting with percutaneous interventions, wherein 2D x-ray images of an object region are recorded before the intervention using a C-arm x-ray system or a robot-based x-ray system at different projection angles and 3D x-ray image data of the object region is reconstructed from the 2D x-ray recordings. One or more 2D or 3D ultrasound images are recorded before and/or during the intervention using an external ultrasound system and registered with the 3D image data. The 2D or 3D ultrasound images are then overlaid with the 3D image data record or a target region segmented therefrom or displayed next to one another in the same perspective. The method allows a puncture or biopsy to be monitored with a low level of radiation.

摘要翻译： 本发明涉及一种辅助经皮干预的方法，其中使用C臂x射线系统或以不同投影角度的基于机器人的x射线系统在介入前记录对象区域的2D x射线图像 并且从2D X射线记录重建对象区域的3D X射线图像数据。 使用外部超声系统在干预之前和/或期间记录一个或多个2D或3D超声图像，并且与3D图像数据一起登记。 然后将2D或3D超声图像与3D图像数据记录或从其分割的目标区域或以相同的视角彼此相邻地显示。 该方法允许以低水平的辐射监测穿刺或活检。

公开(公告)号：US08054941B2

公开(公告)日：2011-11-08

申请号：US12507818

申请日：2009-07-23

申请人： Jan Boese ,  Yu Deuerling-Zheng ,  Michael Zellerhoff

发明人： Jan Boese ,  Yu Deuerling-Zheng ,  Michael Zellerhoff

IPC分类号： H05G1/64 ,  H05G1/60 ,  H05G1/58 ,  G01N23/083

CPC分类号： A61B6/504 ,  A61B5/055 ,  A61B6/4458 ,  A61B6/481 ,  A61B6/488 ,  A61B6/541

摘要： The invention relates to a method for the production of angiography recordings. First, a mask image is recorded with a first modality. A contrast medium is injected after the first recording. A control image is recorded with a second modality after the injection of the contrast medium. A spreading of the contrast medium is determined based on the images and the control of subsequent recordings is analyzed. A recording criterion is checked to determine whether the recording criterion has been achieved. If it has not been achieved, the control image is repeatedly recorded for repeatedly determining the spreading of the contrast medium. If it has been achieved, a contrast image is recorded with the first modality and the mask image and the contrast image are processed and analyzed.

摘要翻译： 本发明涉及一种生产血管造影记录的方法。 首先，以第一模式记录掩模图像。 在第一次记录之后注射造影剂。 在注射造影剂之后，以第二模态记录控制图像。 基于图像确定造影剂的扩展，并分析后续记录的控制。 检查记录标准以确定是否已经实现了记录标准。 如果还没有实现，则重复记录控制图像以重复确定造影剂的扩展。 如果已经实现，则用第一模态记录对比度图像，并且处理和分析掩模图像和对比度图像。

公开(公告)号：US20110268341A1

公开(公告)日：2011-11-03

申请号：US13094423

申请日：2011-04-26

申请人： Jan Boese ,  Frank Dennerlein

发明人： Jan Boese ,  Frank Dennerlein

IPC分类号： G06K9/00 ,  G01N23/04 ,  B82Y99/00

CPC分类号： A61B6/4007 ,  A61B6/4021 ,  A61B6/5205 ,  A61B2090/3764 ,  G06T11/006 ,  G06T2211/412 ,  H01J35/065 ,  H01J2201/30469 ,  H01J2235/062 ,  H01J2235/068

摘要： A method for reconstruction of an actual three-dimensional image dataset of an object during a monitoring process is proposed. Two-dimensional. X-ray projection images which correspond to a recording geometry are continuously recorded from different projection angles. The three-dimensional image dataset are reconstructed from a first number of these projection images, especially by a back projection method. The proportion of the oldest projection image contained in the current three-dimensional image dataset is removed from the three-dimensional image dataset and the proportion of the actual projection image is inserted in the three-dimensional image dataset after each recording of the actual projection image.

摘要翻译： 提出了一种用于在监视过程中重建对象的实际三维图像数据集的方法。 二维。 对应于记录几何的X射线投影图像从不同的投影角度连续记录。 从第一数量的这些投影图像，特别是通过反投影方法重构三维图像数据集。 将包含在当前三维图像数据集中的最旧的投影图像的比例从三维图像数据集中去除，并且在每次记录实际投影图像之后将实际投影图像的比例插入到三维图像数据集中 。

公开(公告)号：US08045780B2

公开(公告)日：2011-10-25

申请号：US11904583

申请日：2007-09-27

申请人： Jan Boese ,  Matthias John ,  Norbert Rahn

发明人： Jan Boese ,  Matthias John ,  Norbert Rahn

IPC分类号： G06K9/00

CPC分类号： G06T15/08 ,  G06T7/38 ,  G06T11/008 ,  G06T2207/10072

摘要： The invention relates to a device for merging a 2D radioscopy image with an image obtained from a 3D image data record, having a memory unit that stores the 2D radioscopy image and the 3D image data record, a segmentation unit that segments an inner surface of a hollow organ from the 3D image data record, a registration unit that registers the 2D radioscopy image with the 3D image data record, a back-projection unit that back-projects the pixels of the 2D radioscopy image onto the segmented surface, taking account of the projection geometry of the 2D radioscopy image and the registration, and an image merger unit that generates a virtual endoscopy view of the surface from the segmented surface using the back-projected pixels. The device primarily allows 2D radioscopy images to be superimposed during interventional procedures with a fly display of the interior of an interesting organ.

摘要翻译： 本发明涉及一种用于将2D放射线图像与从3D图像数据记录获得的图像合并的装置，具有存储2D放射线图像和3D图像数据记录的存储单元，分割单元，其将 来自3D图像数据记录的空心器官，将2D放射线图像与3D图像数据记录注册的登记单元，将2D放射线图像的像素反投影到分割表面上的背投影单元，考虑到 2D放射线图像的投影几何图像和配准，以及图像合并单元，其使用后投影像素从分割表面生成表面的虚拟内窥镜视图。 该装置主要允许在介入手术过程中叠加2D放射成像图像，并显示有趣器官内部的飞行显示。

公开(公告)号：US08023707B2

公开(公告)日：2011-09-20

申请号：US12079142

申请日：2008-03-25

申请人： Jan Boese ,  Yu Deuerling-Zheng

发明人： Jan Boese ,  Yu Deuerling-Zheng

IPC分类号： G06K9/00 ,  A61B6/00

CPC分类号： A61B6/481 ,  A61B6/4441 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  G06T5/50 ,  G06T7/0012 ,  G06T2207/10116 ,  G06T2207/30048

摘要： The invention relates to an evaluation method for mapping the myocardium of a patient, in particular the automated, functional evaluation, for instance the heart perfusion, in angiographic series with the steps: recording a series of angiographic recordings directly after administering a contrast agent to the patient; determining a reference area in an angiographic recording; determining a trend pattern of the contrast agent as a reference curve within the reference area from the series of angiographic recordings; obtaining trend patterns of the contrast agent from all areas of the angiographic recordings; determining the correlation between the trend patterns and the reference curve as a measure for the interrelationship between statistical variables, comparison with stored reference curve; comparison of the correlation coefficient with a threshold value; and reproduction of a marker identifying the myocardium.

摘要翻译： 本发明涉及用于映射患者心肌的评估方法，特别是血管造影系列中的自动功能评估（例如心脏灌注），其步骤为：在将造影剂施用于患者之后直接记录一系列血管造影记录 患者; 确定血管造影记录中的参考区域; 确定造影剂的趋势图案作为来自该系列血管造影记录的参考区域内的参考曲线; 从血管造影记录的所有区域获得造影剂的趋势图; 确定趋势模式和参考曲线之间的相关性，作为统计变量之间相互关系的度量，与存储的参考曲线进行比较; 相关系数与阈值的比较; 以及识别心肌的标记物的繁殖。