公开(公告)号：US09644012B2

公开(公告)日：2017-05-09

申请号：US13634519

申请日：2010-10-27

Applicant: Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Kerstin Nordling

Inventor： Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Kerstin Nordling

IPC: C07K14/435 ,  C12N15/62

CPC classification number: C07K14/43518 ,  C12N15/62

Abstract: A method of producing a desired non-spidroin protein or polypeptide is comprising the steps of expressing in a suitable host a fusion protein, obtaining a mixture containing the fusion protein, and optionally isolating the fusion protein. The fusion protein is comprising at least one solubility-enhancing moiety which is derived from the N-terminal (NT) fragment of a spider silk protein. It is further comprising at least one moiety which is a desired non-spidroin protein or polypeptide. Each solubility-enhancing moiety is linked directly or indirectly to the desired protein or polypeptide moiety.

公开(公告)号：US08708609B2

公开(公告)日：2014-04-29

申请号：US13219025

申请日：2011-08-26

Applicant: Thomas Sågström ,  Jan Johansson

Inventor： Thomas Sågström ,  Jan Johansson

IPC: B23F21/14

CPC classification number: B23F21/14 ,  B23F21/146 ,  Y10T407/1705 ,  Y10T407/1745 ,  Y10T407/1962 ,  Y10T407/23

Abstract: Gear milling cutter with replaceable milling inserts mounted on flank sides. Some are root inserts placed in tangentially spaced-apart positions along the periphery of the basic body; others are flank inserts tangentially spaced-apart and in ring formation radially inside the root inserts. Sweep areas of radially separated inserts overlap in a ring-shaped overlapping zone by radially inner ends of root inserts being situated nearer the center axis than radially outer ends of the flank insert next inside. A part edge of the cutting edge, located between the straight main edge and one of the ends of the insert is shorter than the main edge and deviates from a straight reference line in the extension of the main edge at a deviation angle of at most 10°. Cutting edges of root inserts overlap cutting edges of flank inserts in a point of intersection situated between end points of the part edges.

Abstract translation: 齿轮铣刀，可更换的铣刀安装在侧面。 一些是沿着基体的周边沿切向间隔开的位置放置的根部插入物; 其他的是沿切向间隔的侧面插入件，并且在根部插入件的径向内部形成环形。 径向分离的插入物的扫掠区域在环形重叠区域中重叠，根部插入物的径向内端位于比中间轴线更靠近侧面插入件的内侧的径向外端。 位于直的主边缘和插入件的一端之间的切削刃的一部分边缘比主边缘短，并且偏离主边缘的延伸部中的直线参考线，偏移角最大为10° °。 根部刀片的切削刃与位于刀片边缘端点之间的相交点处的侧刀片的切削刃重叠。

公开(公告)号：US08200267B2

公开(公告)日：2012-06-12

申请号：US12239480

申请日：2008-09-26

Applicant: Aijun Cao ,  Andreas Jakobsson ,  Jan Johansson ,  Fredrik Lundberg

Inventor： Aijun Cao ,  Andreas Jakobsson ,  Jan Johansson ,  Fredrik Lundberg

IPC: H04B7/00 ,  H04B17/00 ,  H04W68/00

CPC classification number: H04W68/00 ,  H04W24/10 ,  H04W28/18

Abstract: A robust method of page indication (PI) detection improves the probability of detecting a transmitted PI under conditions that decrease the probability of accurate PI detection. The method includes choosing a standard value of a PI threshold against which to compare accumulated PI bits when the probability of correctly detecting the PI is high, and choosing a derived value of the PI threshold lower than the standard value when the probability of correctly detecting the PI is low. The derived PI threshold value determination includes a factor indicative of a desired probability of accurate PI detection.

Abstract translation: 强大的页面指示（PI）检测方法提高了在降低精确PI检测概率的条件下检测传输PI的概率。 该方法包括：当正确检测PI的概率高时，选择PI阈值的标准值，以便比较累积的PI比特，以及当正确检测到的PI的概率时，选择PI阈值的导出值低于标准值 PI低。 导出的PI阈值确定包括指示精确PI检测的期望概率的因子。

公开(公告)号：US08183210B2

公开(公告)日：2012-05-22

申请号：US12422581

申请日：2009-04-13

Applicant: Jan Johansson ,  Tore Curstedt ,  Bengt Robertson ,  Joakim Robertson, legal representative ,  Soeren Robertson, legal representative ,  Magnus Robertson, legal representative ,  Charlotte Robertson, legal representative ,  Gertie Robertson Grossmann, legal representative

Inventor： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson

IPC: A61K38/16

CPC classification number: A61K38/395 ,  A61K38/00 ,  C07K14/785

Abstract: Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders.

Abstract translation: 包含脂质载体，天然表面活性蛋白SP-C的多肽类似物和天然表面活性蛋白SP-B的多肽类似物的重构表面活性剂可用于治疗和/或预防RDS和其它呼吸系统疾病。

公开(公告)号：US20120122794A1

公开(公告)日：2012-05-17

申请号：US13145096

申请日：2010-01-29

Applicant: Jan Johansson

Inventor： Jan Johansson

IPC: A61K38/17 ,  A61P25/28

CPC classification number: A61K38/395 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/785

Abstract: An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the C-terminal domain of lung surfactant protein C precursor (CTproSP-C, “CTC”) from a mammal; and (ii) proteins comprising an amino acid sequence having at least 70% identity to the Brichos domain of CTproSP-C from a mammal, is disclosed for treatment of Alzheimer's disease in a mammal, including man.

Abstract translation: 选自以下的分离蛋白质：（i）包含与来自哺乳动物的肺表面活性蛋白C前体（CTproSP-C，“CTC”）的C-末端结构域具有至少70％同一性的氨基酸序列的蛋白质; 公开了包含与来自哺乳动物的CTproSP-C的Brichos结构域具有至少70％同一性的氨基酸序列的蛋白质，包括人在内的哺乳动物治疗阿尔茨海默氏病。

公开(公告)号：US08173772B2

公开(公告)日：2012-05-08

申请号：US12087289

申请日：2006-12-28

Applicant: Jan Johansson ,  Göran Hjälm ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

Inventor： Jan Johansson ,  Göran Hjälm ,  Margareta Stark ,  Anna Rising ,  Stefan Grip ,  Wilhelm Engström ,  My Hedhammar

IPC: C07K1/00 ,  C07K14/00

CPC classification number: C07K14/43518 ,  A61K35/12 ,  A61K47/42 ,  D01F4/00

Abstract: The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula KEP-CT. KEP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.

Abstract translation: 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式KEP-CT定义。 KEP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。

公开(公告)号：US08102185B2

公开(公告)日：2012-01-24

申请号：US12242133

申请日：2008-09-30

Applicant: Jan Johansson ,  Andrew J. Berkley

Inventor： Jan Johansson ,  Andrew J. Berkley

IPC: H01L39/22 ,  H03K19/195

CPC classification number: G06N99/002 ,  B82Y10/00

Abstract: A transverse coupling system may include a first qubit, a second qubit, a first conductive path capacitively connecting the first qubit and the second qubit, a second conductive path connecting the first qubit and the second qubit, and a dc SQUID connecting the first and the second conductive paths wherein the compound junction loop is threaded by an amount of magnetic flux.

Abstract translation: 横向耦合系统可以包括第一量子比特，第二量子比特，电容性地连接第一量子位和第二量子位的第一导电路径，连接第一量子位和第二量子位的第二导电路径，以及连接第一和第二量子位的直流SQUID 第二导电路径，其中复合连接环被一定量的磁通量穿过。

公开(公告)号：US20110306007A1

公开(公告)日：2011-12-15

申请号：US13143654

申请日：2010-01-20

Applicant: Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

Inventor： Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

IPC: A61C5/04

CPC classification number: A61C5/127 ,  A61C5/85 ,  A61C5/88

Abstract: A dental instrument, suitable for use when creating a dental filling is provided. The dental instrument comprises a wedge and a matrix. The matrix is fixedly attached to the wedge, and the wedge is adapted to be inserted into the approximal space between two teeth of a patient. The wedge comprises a bow shape along a length axis of the wedge, the matrix comprises a first bow shape along a length axis of the matrix, and the matrix comprises a second bow shape along an axis perpendicular to the length axis of the matrix. A method of using the dental instrument and a disposable system, which further comprises a protective member, is further provided.

Abstract translation: 提供适合在创建牙科填充物时使用的牙科器械。 牙科仪器包括楔形物和矩阵。 矩阵固定地附接到楔形件，楔形件适于插入患者的两个牙齿之间的近似空间中。 楔形物包括沿着楔形物的长度轴的弓形，矩阵包括沿着矩阵的长轴的第一弓形形状，并且矩阵包括沿垂直于矩阵长度轴的轴线的第二弓形形状。 还提供了一种使用牙科器械的方法和还包括保护构件的一次性系统。

公开(公告)号：US08057132B2

公开(公告)日：2011-11-15

申请号：US12488732

申请日：2009-06-22

Applicant: Jan Johansson ,  Anders Liljerehn

Inventor： Jan Johansson ,  Anders Liljerehn

IPC: B23C5/20

CPC classification number: B23C5/202 ,  B23C2200/125 ,  B23C2200/165 ,  B23C2200/286 ,  B23C2210/0407 ,  Y10T407/1924 ,  Y10T407/1936 ,  Y10T407/23

Abstract: An indexable milling insert, including an upperside, an underside parallel to an imaginary reference plane, and two cutting edges. Each cutting edge includes a cutting edge line and is formed between a chip surface included in the upperside and a first clearance surface extending between the upperside and the underside, the first clearance surface forming an acute, nominal first clearance angle (α) with a normal to the reference plane. Each cutting edge includes a main edge, which is at least partly convexly curved as viewed in plane elevation from above, and which extends from an initial end, which determines the maximal cutting depth of the milling insert, to a corner edge having a radius of curvature that is smaller than the radius of curvature of the main edge, the main edge rising in the direction from the initial end toward the corner edge such that the distance thereof to the underside successively increases in the direction. A second clearance surface is formed between the cutting edge line and the first clearance surface, the second clearance surface having a width of at most 0.3 mm and a nominal second clearance angle (λ) that is smaller than the first clearance angle. The second clearance surface is of uniform width and the second clearance angle decreases successively in the direction from the initial end toward the corner edge.

Abstract translation: 一个可转位铣削刀片，包括上侧，平行于虚拟参考平面的下侧和两个切削刃。 每个切削刃包括切削刃线，并且形成在包括在上侧的切屑表面和在上侧和下侧之间延伸的第一间隙表面之间，第一间隙表面形成具有正常的锐角的标称第一间隙角（α） 到参考平面。 每个切削刃包括主边缘，该主边缘从俯视图中至少部分地凸起弯曲，并且从初始端延伸，该初始端将铣削刀片的最大切削深度确定为具有半径为 曲率小于主边缘的曲率半径，主边沿从初始端朝向角边缘的方向上升，使得其向下侧的距离在该方向上连续增加。 第二间隙表面形成在切削刃线和第一间隙表面之间，第二间隙表面具有至多0.3mm的宽度和小于第一间隙角的标称第二间隙角（λ）。 第二间隙表面具有均匀的宽度，并且第二间隙角度在从初始端朝向拐角边缘的方向上连续减小。

公开(公告)号：US20110190196A1

公开(公告)日：2011-08-04

申请号：US12999966

申请日：2009-06-17

Applicant: John K. Bielicki ,  Jan Johansson

Inventor： John K. Bielicki ,  Jan Johansson

IPC: A61K38/10 ,  C07K4/00 ,  C07K19/00 ,  C07K1/107 ,  A61P3/00 ,  A61P9/10

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/00

Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

Abstract translation: 本发明提供了具有与全长载脂蛋白（例如Apo AI和Apo E）平行的胆固醇流出活性的非天然存在的多肽的家族，并且对于与全长载脂蛋白的ABAC1平行的ABAC1具有高选择性。 本发明还提供包含这些多肽的组合物，鉴定，筛选和合成这些多肽的方法，以及治疗，预防或诊断与血脂异常，高胆固醇血症和炎症相关的疾病和病症的方法。