-
公开(公告)号：US08173772B2
公开(公告)日：2012-05-08
申请号：US12087289
申请日：2006-12-28
申请人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
发明人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00
摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula KEP-CT. KEP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
摘要翻译： 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式KEP-CT定义。 KEP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。
-
公开(公告)号：US08278416B1
公开(公告)日：2012-10-02
申请号：US13441118
申请日：2012-04-06
申请人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
发明人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00
摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
摘要翻译： 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式REP-CT定义。 REP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。
-
公开(公告)号：US20120329992A1
公开(公告)日：2012-12-27
申请号：US13598119
申请日：2012-08-29
申请人： Jan JOHANSSON , Göran HJÄLM , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
发明人： Jan JOHANSSON , Göran HJÄLM , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
IPC分类号： C07K14/435 , C12P21/02 , C12N15/62 , C07K19/00 , C12N15/12
CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00
摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
-
公开(公告)号：US20090226969A1
公开(公告)日：2009-09-10
申请号：US12087289
申请日：2006-12-28
申请人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
发明人： Jan Johansson , Göran Hjälm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
IPC分类号： C12P21/00 , C07K14/435 , C07H21/00 , C07K1/107
CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00
摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula KEP-CT. KEP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
摘要翻译： 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式KEP-CT定义。 KEP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。
-
公开(公告)号：US08618255B2
公开(公告)日：2013-12-31
申请号：US13598119
申请日：2012-08-29
申请人： Jan Johansson , Göran Hjäm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
发明人： Jan Johansson , Göran Hjäm , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar
CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00
摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
摘要翻译： 本发明提供了一种分离的主要的安瓿蛋白质宿主蛋白，其由150至420个氨基酸残基组成，并由式REP-CT定义。 REP是具有80至300个氨基酸残基的重复的N末端衍生的蛋白质片段。 CT是具有70至120个氨基酸残基的C末端衍生的蛋白质片段。 本发明进一步提供了由第一蛋白片段（其是主要的安非他索特灵素蛋白质）和包含融合配偶体和切割剂识别位点的第二蛋白质片段组成的分离的融合蛋白质。 第一个蛋白质片段通过所述切割剂识别位点连接到融合配偶体。 本发明还提供了一种生产主要的安非他命复合蛋白及其聚合物的方法。
-
-
-
-
搜索结果
5 条记录 (耗时 0.029 秒)
