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    Compositions and methods for the diagnosis and treatment of tumor
    57.
    发明授权
    Compositions and methods for the diagnosis and treatment of tumor 失效
    用于诊断和治疗肿瘤的组合物和方法

    公开(公告)号：US08398982B2

    公开(公告)日：2013-03-19

    申请号：US12422424

    申请日：2009-04-13

    申请人： Patrick Dowd ,  Gretchen Frantz ,  Paul Polakis ,  Victoria Smith ,  Susan D. Spencer ,  Thomas D. Wu ,  Zemin Zhang

    发明人： Patrick Dowd ,  Gretchen Frantz ,  Paul Polakis ,  Victoria Smith ,  Susan D. Spencer ,  Thomas D. Wu ,  Zemin Zhang

    IPC分类号： A61K39/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/18 ,  C07K2317/73

    摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody. Methods of diagnosing the presence of a tumor in a mammal using such antibodies are disclosed, wherein detection of the formation of a complex between an antibody and a protein in a test sample is indicative of the presence of a tumor in said mammal. Methods of inhibiting the growth of a cancer cell that expresses a protein comprising the amino acid sequence of SEQ ID NO: 2, are disclosed, where the binding of the antibody to the protein inhibits the growth of the cell. Methods of inhibiting the growth of a cancer cell include methods wherein the antibody binds to the epitope bound by an antibody produced by a disclosed hybridoma cell line.

    摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 公开了包含SEQ ID NO：2的氨基酸序列的TAT113多肽。 公开了结合TAT113多肽，包括单克隆，嵌合，人源化，单链和其他抗体及其片段的抗体。 提供了鉴定结合这些抗体结合表位的抗体的方法，包括由本申请中公开的杂交瘤细胞系产生的抗体，其中一种抗体阻断另一种抗体与TAT113多肽的结合的能力表明一种抗体结合 到由另一抗体结合的表位。 公开了使用这种抗体诊断哺乳动物肿瘤存在的方法，其中检测样品中抗体与蛋白质之间的复合物的形成是指示所述哺乳动物中肿瘤的存在。 公开了抑制表达包含SEQ ID NO：2的氨基酸序列的蛋白质的癌细胞的生长的方法，其中抗体与蛋白质的结合抑制细胞的生长。 抑制癌细胞生长的方法包括其中抗体结合由所公开的杂交瘤细胞系产生的抗体结合的表位的方法。