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公开(公告)号：US07745639B2
公开(公告)日：2010-06-29
申请号：US10506702
申请日：2003-03-04
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , J. Christopher Culberson , George D. Hartman , Brenda J. Mariano , Maricel Torrent
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , J. Christopher Culberson , George D. Hartman , Brenda J. Mariano , Maricel Torrent
IPC分类号： C07D231/06 , A01N43/56
CPC分类号： C07D401/04 , C04B35/632 , C07D231/06 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080194582A1
公开(公告)日：2008-08-14
申请号：US11886274
申请日：2006-03-10
IPC分类号： A61K31/496 , A61K31/415 , C07D231/06 , C07D403/02 , A61P35/00
CPC分类号： C07D231/06
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080102068A1
公开(公告)日：2008-05-01
申请号：US11795440
申请日：2006-01-13
申请人： Paul J. Coleman , George D. Hartman
发明人： Paul J. Coleman , George D. Hartman
IPC分类号： A61K31/519 , A61K39/395 , A61P35/00 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to fluorinated 2-aminomethylthienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的氟化2-氨基甲基噻吩并嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07632839B2
公开(公告)日：2009-12-15
申请号：US11795435
申请日：2006-01-13
申请人： Paul J. Coleman , George D. Hartman
发明人： Paul J. Coleman , George D. Hartman
IPC分类号： C07D471/04 , A61K31/519 , C07D498/04 , C07D213/75 , C07F7/04 , A61P35/00
CPC分类号： C07D417/04
摘要： The present invention relates to fluorinated aminoalkyl-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的氟化氨基烷基-4-氧代-3,4-二氢吡啶并[3,4-d]嘧啶衍生物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20090118200A1
公开(公告)日：2009-05-07
申请号：US11920596
申请日：2006-05-22
申请人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
发明人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
IPC分类号： A61K38/05 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/4184 , A61P25/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20080207693A1
公开(公告)日：2008-08-28
申请号：US11886282
申请日：2006-03-10
IPC分类号： A61K31/454 , C07D263/52 , C07D295/00 , A61P35/00 , A61K31/424
CPC分类号： C07D401/12 , C07D207/20
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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![Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor](/abs-image/US/2007/08/28/US07262186B2/abs.jpg.150x150.jpg)
57.发明授权Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor 失效取代的吡唑并[3,4-d]嘧啶酮作为有丝分裂驱动蛋白抑制剂公开(公告)号：US07262186B2
公开(公告)日：2007-08-28
申请号：US10497385
申请日：2002-12-02
IPC分类号： C07D487/04 , C07D413/12 , C07D243/08 , A61K31/519 , A61K31/497 , A61K31/5355 , A61K31/551
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的偶氮吡啶酮酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07109204B2
公开(公告)日：2006-09-19
申请号：US10485296
申请日：2002-07-26
申请人： Mark E. Fraley , Kenneth L. Arrington , William F. Hoffman , George D. Hartman , Jennifer P. Peckham
发明人： Mark E. Fraley , Kenneth L. Arrington , William F. Hoffman , George D. Hartman , Jennifer P. Peckham
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US20080274107A1
公开(公告)日：2008-11-06
申请号：US12148649
申请日：2008-04-21
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： A61K39/395 , C07D215/20 , A61K31/337 , A61K31/445 , A61K31/47 , A61P43/00
CPC分类号： C07D401/14 , A61K31/495 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法 ，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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公开(公告)号：US07378411B2
公开(公告)日：2008-05-27
申请号：US10497553
申请日：2002-12-02
IPC分类号： C07D495/04 , C07D413/06 , C07D413/08 , C07D243/08 , C07D243/14 , C07D245/02 , C07D245/06 , A61K31/519 , A61K31/5355 , A61K31/551 , A61K31/5513 , A61P35/04
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的噻吩并嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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