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公开(公告)号：US20070020674A1
公开(公告)日：2007-01-25
申请号：US11501979
申请日：2006-08-10
申请人： Kai Krohn , Maarit Heino , Part Peterson , Hamish Scott , Stylianos Antonarakis , Maria Lalioti , Nobuyoshi Shimizu , Jun Kudoh
发明人： Kai Krohn , Maarit Heino , Part Peterson , Hamish Scott , Stylianos Antonarakis , Maria Lalioti , Nobuyoshi Shimizu , Jun Kudoh
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/4713 , A61K38/00
摘要： The present invention relates to a method for the diagnosis of a disease related to immune maturation and regulation of immune response towards self and nonself, comprising the steps of detecting in a biological specimen the presence of a DNA sequence comprising the sequence of SEQ ID NO:1.
摘要翻译： 本发明涉及一种用于诊断与免疫成熟有关的疾病和对自身和非自身的免疫应答调节的方法，包括以下步骤：在生物样本中检测包含SEQ ID NO： 1。
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公开(公告)号：US07111870B2
公开(公告)日：2006-09-26
申请号：US10795428
申请日：2004-03-09
申请人： Nobuyoshi Shimizu
发明人： Nobuyoshi Shimizu
IPC分类号： B60R21/16
CPC分类号： B60R21/017 , B60R21/0132
摘要： An airbag system comprises an airbag, an inflator, a squib, a high-side switch, a low-side switch, a firing circuit for switching the two switches, a first motion detecting circuit including an acceleration sensor, a second motion detecting circuit including an acceleration sensor, a first collision determining circuit for outputting a firing signal to the firing circuit, and a second collision determining circuit for outputting a firing signal to the firing circuit. The first collision determining circuit comprises an analog comparator for comparing a signal from the first motion detecting circuit with a reference value.
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公开(公告)号：US20050170366A1
公开(公告)日：2005-08-04
申请号：US10846374
申请日：2004-05-13
申请人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
发明人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , A01K67/027 , A61K7/06 , A61K7/11 , C07H21/04
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4741
摘要： The present invention relates to provide a protein group binding to keratin which is the major component of body hair, or genes encoding the same, particularly to keratin-associated proteins (KAP) which bind specifically and strongly to hair keratin or genes encoding the same. The base sequence of eurochromtic region of approximately 33.5 Mb of human chromosome 21 was determined, a dot-matrix analysis of the base sequence of the long arm region of chromosome 21 (21q22.3) was carried out, homology search was made to low frequency repetitive sequences and 16 KAP genes being expressed only in hair root cells were found. Moreover, the high frequency repetitive sequences present in the sequence spanning for approximately 1 Mb between CLDN8 gene and TIAM1 gene in the long arm region of chromosome 21 (21q22.11) were masked, the presence or absence of short low frequency repetitive sequence was searched, and 22 KAP genes were found. Moreover, a group of functional peptide was designed from the above mentioned KAPs.
摘要翻译： 本发明涉及提供与作为身体毛发的主要成分的角蛋白结合的蛋白质组，或编码其的基因，特别是与毛发角蛋白特异性强烈结合的角蛋白相关蛋白（KAP）或其编码基因的角蛋白相关蛋白（KAP）。 测定21号染色体约33.5Mb的欧洲色素碱基序列，对21号染色体长臂区（21q22.3）的碱基序列进行点阵分析，对低频进行同源性检索 发现重复序列和仅在发根细胞中表达的16个KAP基因。 此外，染色体21（21q22.11）的长臂区域中CLDN8基因和TIAM1基因之间跨越约1Mb的序列中存在的高频重复序列被掩蔽，搜索是否存在短的低频重复序列 ，发现22个KAP基因。 此外，从上述KAP设计了一组功能性肽。
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公开(公告)号：US20050003385A1
公开(公告)日：2005-01-06
申请号：US10776604
申请日：2004-02-12
摘要： This invention provides an isolated DNA or gene that is responsible for Parkinson's disease and is useful in diagnosing and treating the disease etc. The isolated DNA or gene according to this invention comprises a full-length base sequence according to the sequence ID. No. 1 or 3, or a partial sequence thereof, or a base sequence hybridizable thereto or hybridizable with a complementary strand thereof, and being associated with Parkinson's disease.
摘要翻译： 本发明提供了负责帕金森氏病的分离的DNA或基因，并且可用于诊断和治疗疾病等。根据本发明的分离的DNA或基因包含根据序列ID的全长碱基序列。 或其部分序列，或可与其杂交的碱基序列或与其互补链杂交，并与帕金森病相关。
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公开(公告)号：US06716621B1
公开(公告)日：2004-04-06
申请号：US09601844
申请日：2000-08-09
IPC分类号： C12N1574
摘要： This invention provides an isolated DNA or gene that is responsible for Parkinson's disease and is useful in diagnosing and treating the disease etc. The isolated DNA or gene according to this invention comprises a full-length base sequence according to the sequence ID. No. 1 or 2, or a partial sequence thereof, or a base sequence hybridizable thereto or hybridizable with a complemental strand thereof, and being associated with Parkinson's disease.
摘要翻译： 本发明提供负责帕金森病的分离的DNA或基因，并且可用于诊断和治疗疾病等。根据本发明的分离的DNA或基因包含根据序列ID的全长碱基序列。 或其部分序列，或可与其杂交的碱基序列或与其互补链杂交，并与帕金森病相关。
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公开(公告)号：US4414078A
公开(公告)日：1983-11-08
申请号：US357665
申请日：1982-03-12
申请人： Nobuyoshi Shimizu , Kinji Saijo , Kenji Hizuka , Tsuneo Inui , Yoshikazu Kondo
发明人： Nobuyoshi Shimizu , Kinji Saijo , Kenji Hizuka , Tsuneo Inui , Yoshikazu Kondo
摘要： A method for the pretreatment of tin-free steel which comprises an anodic treatment or an anodic treatment after a cathodic treatment of an acid pickled steel sheet in an alkaline electrolyte with a pH of above 8, said steel sheet consisting of an upper layer of hydrated chromium oxide and a lower layer of metallic chromium. This pretreated tin-free steel has excellent lacquer adhesion after aging in hot water and under retort conditions.
摘要翻译： 一种无锡钢的预处理方法，其特征在于，在pH值高于8的碱性电解液中对酸洗钢板进行阴极处理后进行阳极处理或阳极处理，所述钢板由上层水合物 氧化铬和下层金属铬。 这种预处理的无锡钢在热水和蒸煮条件下老化后具有优异的漆附着力。
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公开(公告)号：US08568983B2
公开(公告)日：2013-10-29
申请号：US12698074
申请日：2010-02-01
CPC分类号： C12Q1/6895
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 3 and mutated sequences thereof.
摘要翻译： 提供探针，一组探针和探针或探针载体，探针或探针组固定在其上，用于分类真菌。 探针或一组探针能够共同检测相同物种的真菌，并将这些真菌与其他物种的真菌区分开来。 探针是用于检测病原真菌DNA的寡核苷酸探针，包括SEQ ID NOS的至少一个碱基序列。 1至3及其突变序列。
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公开(公告)号：US08404447B2
公开(公告)日：2013-03-26
申请号：US12698082
申请日：2010-02-01
CPC分类号： C12Q1/6895
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 2 and mutated sequences thereof.
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公开(公告)号：US20120219951A1
公开(公告)日：2012-08-30
申请号：US13453951
申请日：2012-04-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 2 and mutated sequences thereof.
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公开(公告)号：US08140224B2
公开(公告)日：2012-03-20
申请号：US11982777
申请日：2007-11-05
申请人： Nobuyoshi Shimizu , Masahiko Itoh
发明人： Nobuyoshi Shimizu , Masahiko Itoh
IPC分类号： B60R22/00
CPC分类号： B60R21/0173
摘要： A diagnosis apparatus for an airbag system includes a squib, a driving transistor connected in series with the squib to activate the squib by driving current when driven by a control circuit. The control circuit drives the driving transistor to supply small monitoring current periodically to the squib under slew rate control. As a result, a change rate of rise and fall of each monitoring current is reduced to about 0.1 mA/μs or less thereby reducing radio noise.
摘要翻译： 一种用于气囊系统的诊断装置包括一个点火器，一个与爆管串联的驱动晶体管，通过控制电路驱动时驱动电流来激活点火器。 控制电路驱动驱动晶体管，在转换速率控制下周期性地向爆管提供小的监控电流。 结果，每个监测电流的上升和下降的变化率降低到约0.1mA /μs或更小，从而降低无线电噪声。
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