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    Bituminous coal reagent and flotation process
    51.
    发明授权
    Bituminous coal reagent and flotation process 失效
    烟煤试剂和浮选工艺

    公开(公告)号：US4308132A

    公开(公告)日：1981-12-29

    申请号：US838237

    申请日：1977-09-30

    申请人： James R. McCarthy

    发明人： James R. McCarthy

    IPC分类号： B03B1/04 ,  B03D1/00 ,  B03D1/006 ,  B03D1/012 ,  B03D1/02 ,  B03B1/00

    CPC分类号： B03D1/00 ,  B03B1/04 ,  B03D1/002 ,  B03D1/006 ,  B03D1/012 ,  B03D1/018 ,  B03D1/02 ,  B03D2201/007 ,  B03D2203/08

    摘要： A reagent and a method for using the reagent for treating a solid material disposed in a liquid medium and having an oxygen-controlled surface condition. The reagent includes a liquid hydrocarbon, a reducing material and an activator material. The liquid hydrocarbon has a specific gravity different from the specific gravity of the liquid medium. The reducing material is present in an amount sufficient to establish a reducing environment around the solid material for breaking the oxygen control on the surface of the solid material. The activator material is present in an amount sufficient to establish an electrostatic charge on the solid material after the oxygen-controlled surface condition has been broken. A more specific feature of the invention is directed to the method of flotation of extremely fine bituminous coal having an oxygen-controlled surface condition. The reagent is useful in froth flotation processes and in bath flotation and separation processes.

    摘要翻译： 一种试剂和使用该试剂处理设置在液体介质中并具有氧控制表面状态的固体材料的方法。 试剂包括液体烃，还原材料和活化剂材料。 液体烃具有与液体介质的比重不同的比重。 还原材料以足以在固体材料周围建立还原环境的量存在，以破坏固体材料表面上的氧气控制。 活化剂材料的存在量足以在氧气控制的表面状态被破坏之后在固体材料上形成静电荷。 本发明的更具体的特征涉及具有氧控制表面状态的极细煤烟的浮选方法。 该试剂可用于泡沫浮选工艺和浴浮选和分离工艺。

    Processes for preparing linezolid
    52.
    发明授权
    Processes for preparing linezolid 有权
    制备利奈唑胺的方法

    公开(公告)号：US09206141B2

    公开(公告)日：2015-12-08

    申请号：US13695211

    申请日：2011-04-28

    申请人： James R. McCarthy

    发明人： James R. McCarthy

    IPC分类号： C07D265/30 ,  C07D263/20

    CPC分类号： C07D263/20

    摘要： Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.

    摘要翻译： 本文描述了制备利奈唑胺的方法和中间体及其药学上可接受的盐。

    Thiophenopyrimidines
    54.
    发明授权
    Thiophenopyrimidines 有权
    噻吩并嘧啶

    公开(公告)号：US06469166B2

    公开(公告)日：2002-10-22

    申请号：US09896250

    申请日：2001-06-29

    申请人： Thomas R. Webb ,  Chen Chen ,  James R. McCarthy ,  Terence J. Moran

    发明人： Thomas R. Webb ,  Chen Chen ,  James R. McCarthy ,  Terence J. Moran

    IPC分类号： C07D49504

    CPC分类号： C07D495/04

    摘要： This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein X is S, SO or SO2; R1 is NR4R5 or OR5; R2 is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R4 is hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxyC1-6alkyl; R5 is C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar1CH2, C1-6alkyloxy-C1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl; or a radical of formula -Alk-O—CO-Ar1; or R4 and R5 taken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group; Ar is phenyl, substituted phenyl, pyridinyl or substituted pyridinyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

    摘要翻译： 本发明涉及包括立体异构体及其药学上可接受的酸加成盐形式的化合物，其中X是S，SO或SO 2; R1是NR4R5或OR5; R2是C1-6烷基，C1-6烷氧基或C1-6烷硫基; R3是氢，C1-6烷基，C1-6烷基磺酰基，C1-6烷基亚磺酰基或C1-6烷硫基; R4是氢，C1-6烷基，一或二（C3-6环烷基）甲基，C3-6环烷基，C3-6烯基，羟基C1-6烷基，C1-6烷基羰基氧基C 1-6烷基或C 1-6烷氧基C 1-6烷基; R5是C1-6烷基，单或二（C3-6环烷基）甲基，Ar1CH2，C1-6烷氧基-C 1-6烷基，羟基C 1-6烷基，C 3-6烯基，噻吩基甲基，呋喃基甲基，C 1-6烷硫基C 1-6烷基，吗啉基，单或 二（C 1-6烷基）氨基C 1-6烷基，二（C 1-6烷基）氨基，C 1-6烷基羰基C 1-6烷基，被咪唑基取代的C 1-6烷基; 或式-Alk-O-CO-Ar1基团; 或R 4和R 5与它们所连接的氮原子一起可以形成任选取代的吡咯烷基，哌啶基，高哌啶基或吗啉基; Ar是苯基，取代的苯基，吡啶基或取代的吡啶基; 具有CRF受体拮抗特性; 含有这些化合物作为活性成分的药物组合物; 通过施用有效量的式（I）化合物来治疗与CRF过度分泌有关的疾病的方法，例如抑郁症，焦虑症，药物滥用。

    Fluorinated neurokinin A antagonists
    55.
    发明授权
    Fluorinated neurokinin A antagonists 失效
    氟化神经激肽A拮抗剂

    公开(公告)号：US06218364B1

    公开(公告)日：2001-04-17

    申请号：US08638407

    申请日：1996-04-26

    申请人： Scott L. Harbeson ,  James R. McCarthy

    发明人： Scott L. Harbeson ,  James R. McCarthy

    IPC分类号： A61K3800

    CPC分类号： C07K5/0207 ,  A61K38/00 ,  C07K5/0212 ,  C07K7/22 ,  Y10S514/803

    摘要： Peptide derivatives which are antagonists of neurokinin A. The derivatives have a modified peptide bond having a reduced amide and a fluorinated alkyl attached to the nitrogen atom of the modified peptide bond. For example, Asp-Ser-Phe-Val-Gly-Leu&PSgr;[CH2N(CH2CF3)]Leu(NH2).

    摘要翻译： 作为神经激肽A拮抗剂的肽衍生物。该衍生物具有修饰的肽键，其具有还原的酰胺和与修饰的肽键的氮原子连接的氟化烷基。 例如，Asp-Ser-Phe-Val-Gly-Leu＆PSgr; [CH2N（CH2CF3）] Leu（NH2）。

    Allenyl amines
    60.
    发明授权
    Allenyl amines 失效
    烯丙基胺

    公开(公告)号：US5112852A

    公开(公告)日：1992-05-12

    申请号：US341518

    申请日：1989-04-21

    申请人： James R. McCarthy ,  Thomas M. Bargar ,  Charlotte L. Barney ,  Donald P. Matthews ,  Robert J. Broersma

    发明人： James R. McCarthy ,  Thomas M. Bargar ,  Charlotte L. Barney ,  Donald P. Matthews ,  Robert J. Broersma

    IPC分类号： C07D213/38 ,  C07D231/12 ,  C07D233/54 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D333/58

    CPC分类号： C07D231/12 ,  C07D213/38 ,  C07D233/64 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D333/58 ,  Y02P20/55

    摘要： The present invention relates to allenyl amines, more specifically, .beta.-ethenylidene(substituted) ethanamines, possessing antihypertensive activity, and having the general formula ##STR1## wherein n is the integer 0, 1 or 2; each X independently is a substituent selected from the group consisting of loweralkyl, halo, --O--(loweralkyl), --S--(loweralkyl), --SO--(loweralkyl), --SO.sub.2 --(loweralkyl), CO.sub.2 R and CH.sub.2 OR, wherein R is loweralkyl and each loweralkyl group is from 1 to about 6 carbon atoms, or the pharmaceutically-acceptable addition salts thereof. These compounds are prepared by a novel reaction of a protected N,N-bis(trimethylsilyl)-4-methoxy-2-butynylamine compound with a metallo-organic compound, with subsequent removal of the silyl protecting groups to provide the desired compound.

    摘要翻译： 本发明涉及具有抗高血压活性的具有抗高血压活性的β-亚乙基（取代的）乙胺的亚烯基胺，更具体地，具有通式为：其中n为整数0,1或2; 每个X独立地是选自低级烷基，卤素，-O-（低级烷基），-S-（低级烷基）， - SO-（低级烷基），-SO 2 - （低级烷基），CO 2 R和CH 2 OR的取代基，其中R 是低级烷基，每个低级烷基是1至约6个碳原子，或其药学上可接受的加成盐。 这些化合物通过受保护的N，N-双（三甲基甲硅烷基）-4-甲氧基-2-丁炔胺化合物与金属有机化合物的新反应制备，随后除去甲硅烷基保护基以提供所需化合物。