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    Methods for treating defects and injuries of an intervertebral disc
    51.
    发明授权
    Methods for treating defects and injuries of an intervertebral disc 有权
    治疗椎间盘缺损和损伤的方法

    公开(公告)号：US07740660B2

    公开(公告)日：2010-06-22

    申请号：US11169405

    申请日：2005-06-29

    申请人： Keith Collins ,  Thomas G. Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark D. LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    发明人： Keith Collins ,  Thomas G. Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark D. LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

    摘要： A method for treating a herniated spinal disc between opposing vertebral bodies having a damaged outer annulus and an inner nucleus pulposus comprises the steps of: providing access to the nucleus pulposus through the annulus; removing at least a portion of the nucleus pulposus to create an intradiscal space; applying a first distraction force on the opposing vertebral bodies from within the intradiscal space; applying a second distraction force on the opposing vertebral bodies externally of the intradiscal space; and introducing a curable biomaterial through the annulus access directly into the intradiscal space. The first distraction force is applied within the disc space to distract the anterior aspect of the intradiscal space, while the second distraction force is applied exterior to the disc to act on the posterior aspect of the vertebral bodies. The first distraction force is applied prior to the application of the second distraction force and then removed. The second distraction force is maintained during the introduction of the biomaterial into the intradiscal space.

    摘要翻译： 一种治疗椎间盘突出症的方法，该脊椎椎间盘具有损伤的外环和内髓髓的相对的椎体之间包括以下步骤：提供穿过环的进入髓核的步骤; 去除髓核的至少一部分以产生椎间盘内空间; 在椎间盘内空间内对相对的椎体施加第一分心力; 对椎间盘内空间的相对椎体施加第二分心力; 并通过环形通道将可固化生物材料直接引入椎间盘内空间。 第一牵引力被施加在椎间盘空间内以分散椎间盘内空间的前部，而第二牵引力被施加在椎间外部作用于椎体的后部。 第一牵引力在施加第二牵引力之前施加，然后移除。 在将生物材料引入椎间盘内空间期间，维持第二个牵引力。

    Pre-ignition fuel treatment system
    52.
    发明授权
    Pre-ignition fuel treatment system 失效
    预燃燃油处理系统

    公开(公告)号：US07487764B2

    公开(公告)日：2009-02-10

    申请号：US11889226

    申请日：2007-08-10

    申请人： Dennis Lee

    发明人： Dennis Lee

    IPC分类号： F02M31/18

    CPC分类号： F02M27/02 ,  F02M27/045 ,  F02M31/18 ,  Y02T10/126

    摘要： A method and apparatus for reforming a hydrocarbon fuel which increases the efficiency with which said fuel's energy content may be extracted resulting in improved combustibility and reduction of by-products produced. The hydrocarbon fuel is cracked and ionized in a reactor vessel by means of a feedback loop of electro-chemical interactions with a reactor rod comprised of materials which are both magnetic and catalytic.

    摘要翻译： 一种用于重整碳氢化合物燃料的方法和装置，其提高了可以提取所述燃料的能量含量的效率，从而提高了所产生的副产物的可燃性和还原性。 碳氢化合物燃料通过与包括磁性和催化材料的反应器的电化学相互作用的反馈回路在反应器容器中裂化和离子化。

    Chemical Compounds
    53.
    发明申请
    Chemical Compounds 审中-公开
    化学化合物

    公开(公告)号：US20080275062A1

    公开(公告)日：2008-11-06

    申请号：US10597473

    申请日：2005-01-28

    申请人： David Harold Drewry ,  David Kendall Jung ,  James Andrew Linn ,  Robert Neil Hunter ,  Dennis Lee ,  Robert A. Stavenger ,  Clark Sehon

    发明人： David Harold Drewry ,  David Kendall Jung ,  James Andrew Linn ,  Robert Neil Hunter ,  Dennis Lee ,  Robert A. Stavenger ,  Clark Sehon

    IPC分类号： A61K31/4409 ,  C07D213/04 ,  A61K31/415 ,  C07D231/10 ,  C07D239/42 ,  A61K31/505 ,  C07D239/24 ,  C07D231/56 ,  C07D401/10

    CPC分类号： C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D239/42 ,  C07D403/04

    摘要： There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-4alkyl, C1-4alkanoyl, C1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy and C1-4alkoxycarbonyl; and X is indazolyl, pyrazolyl or a group: wherein G is CH or N; and Y1 and Y2 are independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, C1-6alkyl or C2-6alkenyl).

    摘要翻译： 提供式（I）化合物及其盐，溶剂化物和生理功能衍生物：其中R1是氢或C 1-6烷基; n为1,2,3或4; R2是芳基，任选地被一个或两个选自卤素，羟基，氰基，C 1-4烷基，C 1-4烷氧基，C 1-4烷基， 烷基，卤代C 1-4烷基，卤代C 1-4烷氧基，芳基，芳氧基，C 1-4烷基， 烷氧基羰基，C 1-4烷基磺酰基和基团R 3 R 4 NSO 2（其中R 3和R 4独立地是氢或C 1-4烷基 ）和5-或6-元杂芳基; 或n为0，并且R 1和R 2与它们连接的氮原子一起形成5-或6-元单环杂环或9-或10-元双环杂环，其中至少含有 R 1和R 2连接的氮原子是非芳族的，其中5或6元单环杂环或9或10元双环杂环任选被一个或两个选自以下的基团取代： 卤素，羟基，氰基，氧代，C 1-4烷基，C 1-4烷酰基，C 1-4烷氧基，卤代C 1-4烷基， 烷基，卤代C 1-4烷氧基，芳基，芳氧基和C 1-4烷氧基羰基; 并且X是吲唑基，吡唑基或基团：其中G是CH或N; 和Y 1和Y 2独立地是氢，卤素和基团NR 5 R 6（其中R 5和R 6独立地是氢，C 1-6烷基 或C 2-6烯基）。

    Devices for injecting a curable biomaterial into a intervertebral space
    59.
    发明申请
    Devices for injecting a curable biomaterial into a intervertebral space 有权
    用于将可固化生物材料注射到椎间空间中的装置

    公开(公告)号：US20060009779A1

    公开(公告)日：2006-01-12

    申请号：US11170010

    申请日：2005-06-29

    申请人： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    发明人： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    IPC分类号： A61F2/46

    CPC分类号： A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

    摘要： A vented needle is provided for use in sealably injecting biomaterial into an intradiscal space interiorly of the annulus of a spinal disc and for providing an exhaust for the intradiscal space. The vented needle comprises a compressible seal body for pressing against an outer surface of the annulus, and a needle extending through the seal. The needle may be configured to connect to a syringe for pressure injection of the biomaterial into the needle. The seal includes a vent extending therethrough the seal with an opening for communication with the intradiscal space and an opening for the discharge of excess biomaterial filling the intradiscal space. A kit of parts is also provided for use in the treatment of a spinal disc, the kit comprising the vented needle and an inflatable trial device. The trial device is adapted to be removably introduced into the intradiscal space and inflated therein with a medium capable of determining the size of said intradiscal space created by the removal of at least a portion of said nucleus pulposus.

    摘要翻译： 提供通气针用于将生物材料密封地注入脊椎盘环形内部的椎间盘内空间，并为椎间盘内空间提供排气。 排气针包括用于压靠环形空间的外表面的可压缩密封体和延伸穿过密封件的针。 针可以被配置成连接到注射器，用于将生物材料压入注射针。 密封件包括通过密封件延伸的通气口，其具有用于与椎间盘内空间连通的开口和用于排出填充椎间盘内空间的多余生物材料的开口。 还提供了一套用于治疗脊椎盘的部件，该试剂盒包括通气针和可充气试验装置。 试验装置适于可移除地引入椎间盘内空间，并用能够确定通过去除髓核的至少一部分而产生的所述椎间盘内空间的尺寸的介质膨胀。

    Methods for treating defects and injuries of an intervertebral disc
    60.
    发明申请
    Methods for treating defects and injuries of an intervertebral disc 有权
    治疗椎间盘缺损和损伤的方法

    公开(公告)号：US20060009778A1

    公开(公告)日：2006-01-12

    申请号：US11169405

    申请日：2005-06-29

    申请人： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    发明人： Keith Collins ,  Thomas Wilson ,  Jared Walkenhorst ,  Dennis Lee ,  Andrew Carter ,  John Pafford ,  Mark LoGuidice ,  Lance Middleton ,  Lawrence Boyd

    IPC分类号： A61F2/46 ,  A61F2/44 ,  A61B17/88

    CPC分类号： A61F2/4657 ,  A61B17/70 ,  A61B17/8811 ,  A61B17/8827 ,  A61B2017/0256 ,  A61B2017/564 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61M29/02

    摘要： A method for treating a herniated spinal disc between opposing vertebral bodies having a damaged outer annulus and an inner nucleus pulposus comprises the steps of: providing access to the nucleus pulposus through the annulus; removing at least a portion of the nucleus pulposus to create an intradiscal space; applying a first distraction force on the opposing vertebral bodies from within the intradiscal space; applying a second distraction force on the opposing vertebral bodies externally of the intradiscal space; and introducing a curable biomaterial through the annulus access directly into the intradiscal space. The first distraction force is applied within the disc space to distract the anterior aspect of the intradiscal space, while the second distraction force is applied exterior to the disc to act on the posterior aspect of the vertebral bodies. The first distraction force is applied prior to the application of the second distraction force and then removed. The second distraction force is maintained during the introduction of the biomaterial into the intradiscal space.

    摘要翻译： 一种治疗椎间盘突出症的方法，该脊椎椎间盘具有损伤的外环和内髓髓的相对的椎体之间包括以下步骤：提供穿过环的进入髓核的步骤; 去除髓核的至少一部分以产生椎间盘内空间; 在椎间盘内空间内对相对的椎体施加第一分心力; 对椎间盘内空间的相对椎体施加第二分心力; 并通过环形通道将可固化生物材料直接引入椎间盘内空间。 第一牵引力被施加在椎间盘空间内以分散椎间盘内空间的前部，而第二牵引力被施加在椎间外部作用于椎体的后部。 第一牵引力在施加第二牵引力之前施加，然后移除。 在将生物材料引入椎间盘内空间期间，维持第二个牵引力。