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公开(公告)号：US09237908B2
公开(公告)日：2016-01-19
申请号：US11408725
申请日：2006-04-21
CPC分类号： A61B17/7067 , A61B17/7055 , A61B17/7064 , A61B17/842 , A61B17/8875 , A61B2017/90
摘要： A system for dynamic stabilization of the spine includes a bone engaging fastener configured to be anchored in a vertebra and a deflectable element mounted on the fastener. The deflectable element or bumper is configured and arranged to contact a portion of an adjacent vertebra, such as the facet, during extension of the spine, while offering no resistance during flexion. In certain embodiments, a cable may be fastened to the bone engaging fastener and arranged to contact a portion of the adjacent vertebra, such as the spinous process, during flexion of the spine. In one surgical technique of the invention, a contralateral approach is used to introduce the bone engaging fastener through the deflectable element and into the vertebra.
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公开(公告)号：US08357168B2
公开(公告)日：2013-01-22
申请号：US11850424
申请日：2007-09-05
CPC分类号： A61M5/46 , A61B17/8808 , A61B17/8827 , A61F2/4611 , A61F2002/3085 , A61F2002/444
摘要： A kit for injecting a biomaterial into an intradiscal space accessed through an opening in the disc annulus comprises a plurality of needles, each sized for introduction through the annulus opening with a passageway for injecting the biomaterial therethrough, and each including a distal end to be disposed within the intradiscal space when the needle extends through the annulus opening. Each needle includes a stop affixed thereto at different pre-determined distances from the distal end to define the location of the distal end within the intradiscal space when the needle extends through the opening in the annulus. The kit further includes a plurality of seals defining a bore for sliding engagement with a needle, each of the plurality of seals including a sealing face for engaging the annulus around the needle. Each sealing face defines a differently configured area of contact, such as circular, elliptical, tapered and threaded.
摘要翻译： 用于将生物材料注入通过椎间盘环中的开口进入的椎间盘内空间的套件包括多个针，每个针的尺寸适于通过环形开口引入，用于将生物材料注射通过其中的通道，并且每个针包括待设置的远端 当针穿过环形开口时，在椎间盘内空间内。 每个针包括一个固定在其上的止挡件，其距离远端的预定距离不同，以限定当针穿过环形空间中的开口时的椎间盘内空间内的远端位置。 套件还包括限定用于与针滑动接合的孔的多个密封件，所述多个密封件中的每一个密封件包括用于与环周围的环接合的密封面。 每个密封面限定不同的接触面积，例如圆形，椭圆形，锥形和螺纹。
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公开(公告)号：US20120276008A1
公开(公告)日：2012-11-01
申请号：US13094512
申请日：2011-04-26
申请人： Jared W. Walkenhorst , Keith A. Collins , Dennis Y. Lee , Thomas G. Wilson , Thomas J. Douville , Ulrich Berlemann
发明人： Jared W. Walkenhorst , Keith A. Collins , Dennis Y. Lee , Thomas G. Wilson , Thomas J. Douville , Ulrich Berlemann
IPC分类号： A61K49/00
CPC分类号： A61K49/0457
摘要： In one embodiment, the invention relates to a composition suitable for preparing a hydrogel useful as replacement material for all or part of a disc nucleus. The composition comprises: a curable, cross-linkable, non-immunogenic, non-toxic protein comprising a minimum of about 10% and a maximum of about 25% of the hydrogel by weight; a metal contrast agent comprising a minimum of about 2% and a maximum of about 70% of the hydrogel by weight; and a crosslinker comprising a minimum of about 0.1% and a maximum of about 10% of the hydrogel by weight; wherein the composition has a discernable radiopacity level.
摘要翻译： 在一个实施方案中，本发明涉及适用于制备可用作全部或部分椎间盘核的替代材料的水凝胶的组合物。 该组合物包含：可固化的，可交联的，非免疫原性的无毒性蛋白，其包含至少约10重量％和最多约25重量％的水凝胶; 金属造影剂，其包含按重量计最少约2％和最多约70％的水凝胶; 和包含至少约0.1重量％和最多约10重量％的水凝胶的交联剂; 其中所述组合物具有可辨别的不透射线水平。
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公开(公告)号：US20110097376A1
公开(公告)日：2011-04-28
申请号：US12606422
申请日：2009-10-27
CPC分类号： A61K38/00 , A61F2002/444 , A61K49/04 , A61K49/0433 , A61L27/22 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/38
摘要： A composition suitable for use as replacement material for all or part of a disc nucleus during percutaneous injection, the composition comprising: an injectable, curable, cross-linkable, non-immunogenic non-toxic protein hydrogel that (i) the protein component of the protein hydrogel contains at least one crosslinkable amino acid (ii) has a static compressive modulus of at least about 10 kPa, and (iii) has a dynamic compressive modulus of at least about 10 kPa; an iodinated contrast solution comprising an amount of an iodine compound sufficient to increase radiopacity to a discernable level, wherein the solution causes a decrease in the static and/or dynamic compressive modulus; and an amount of a crosslinker sufficient to restore at least about 100% of the decrease in static and/or dynamic compressive modulus caused by addition of the iodinated contrast solution.
摘要翻译： 一种组合物，其适用于在经皮注射期间用作全部或部分椎间盘核的替代材料，所述组合物包含：可注射的，可固化的，可交联的，非免疫原性的无毒蛋白质水凝胶，其（i）所述蛋白质组分 蛋白质水凝胶含有至少一种可交联氨基酸（ii）具有至少约10kPa的静态压缩模量，和（iii）动态压缩模量为至少约10kPa; 碘化对比溶液，其包含一定量的碘化合物，其足以将不透射线性增加到可辨别的水平，其中所述溶液导致静态和/或动态压缩模量的降低; 和一定量的交联剂足以恢复通过加入碘化对比溶液引起的静态和/或动态压缩模量的降低的至少约100％。
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公开(公告)号：US4903182A
公开(公告)日：1990-02-20
申请号：US325751
申请日：1989-03-20
IPC分类号： H02M3/28 , H02M3/338 , H03K17/0412
CPC分类号： H03K17/04123 , H02M3/3385
摘要： A self oscillating converter with regenerative switching includes circuitry to enhance the gain of circuity to turn off a MOSFET power switch and enhance the regenerative action culminating in turn off in order to eliminate bursting at low loads. The MOSFET power switching device turn off circuitry includes the addition of a supplementary drive transistor operative for counteracting the effects of the parasitic capacitances of the MOSFET power switching device. This permits the converter to operate with the shorter on times and to provide a low ripple output at very low load.
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6.发明授权公开(公告)号：US09073630B2
公开(公告)日：2015-07-07
申请号：US13492385
申请日：2012-06-08
CPC分类号： B64D33/00 , B32B37/18 , B32B38/0004 , B32B2038/0076 , B32B2305/08 , B32B2305/77 , B32B2439/02 , B64C27/04 , B64C27/12 , F16N31/002 , F16N31/006 , Y10T29/49815 , Y10T156/1052 , Y10T156/1082
摘要： A drip pan apparatus for a helicopter includes a frame and a drip pan. The frame is secured to a skirt on the airframe of the helicopter. The apparatus includes a drip pan for cooperation with a frame to cover an access opening to a transmission. The drip pan includes a substantially planar member of a fiber-reinforced composite and has a seal surface that is configured to cooperate with a seal surface of the frame. A seal member may be disposed between the substantially planar member and the frame to form a fluid-tight seal. The fiber-reinforced composite may be a carbon fiber-reinforced composite. A method of making the drip pan apparatus includes placing a plurality of sheets of an uncured fiber-reinforced composite material on one another to form an uncured stack. The uncured stack is then cured. A frame and a drip pan may be cut from the cured stack.
摘要翻译： 用于直升机的滴水盘装置包括框架和滴水盘。 框架固定在直升机的机身上的裙子上。 该装置包括与框架配合以覆盖变速器的进入开口的滴盘。 滴水盘包括纤维增强复合材料的基本平坦的构件，并且具有构造成与框架的密封表面配合的密封表面。 密封构件可以设置在基本平坦的构件和框架之间以形成流体密封。 纤维增强复合材料可以是碳纤维增强复合材料。 制造滴水盘装置的方法包括将多片未固化的纤维增强复合材料片彼此放置以形成未固化的叠层。 然后固化未固化的叠层。 可以从固化的堆叠中切割框架和滴盘。
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7.发明授权Apparatus and kit for injecting a curable biomaterial into an intervertebral space 有权用于将可固化生物材料注射到椎间空间中的装置和试剂盒公开(公告)号：US08337557B2
公开(公告)日：2012-12-25
申请号：US11170657
申请日：2005-06-29
申请人： Keith Collins , Thomas G. Wilson , Andrew Carter
发明人： Keith Collins , Thomas G. Wilson , Andrew Carter
IPC分类号： A61F2/44
CPC分类号： A61F2/4657 , A61B17/70 , A61B17/8811 , A61B17/8827 , A61B2017/0256 , A61B2017/564 , A61F2/4611 , A61F2/4684 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61M29/02
摘要： A kit of parts is provided that comprises: a cannula, the distal end of the cannula adapted to be inserted through the disc annulus; an injection needle, the distal end adapted to be inserted into the proximal end of the cannula and configured for relatively close sliding fit therewithin; and a syringe for containing a quantity of curable biomaterial, the syringe adapted to be coupled to the proximal end of the needle and to inject the biomaterial into the needle under pressure. The kit may further comprise a quantity of curable biomaterial that is selected to have upon curing strong adhesive properties such as a protein polymer.
摘要翻译： 提供了一套零件，其包括：插管，插管的远端适于插入穿过盘环; 注射针，所述远端适于插入所述套管的近端并且被配置为在其中相对较紧的滑动配合; 以及用于容纳一定量的可固化生物材料的注射器，所述注射器适于联接到所述针的近端并且在压力下将所述生物材料注射到所述针中。 该试剂盒还可以包含一定量的可固化生物材料，其被选择为在固化强粘合性能如蛋白质聚合物时具有。
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8.发明申请公开(公告)号：US20120312914A1
公开(公告)日：2012-12-13
申请号：US13492385
申请日：2012-06-08
CPC分类号： B64D33/00 , B32B37/18 , B32B38/0004 , B32B2038/0076 , B32B2305/08 , B32B2305/77 , B32B2439/02 , B64C27/04 , B64C27/12 , F16N31/002 , F16N31/006 , Y10T29/49815 , Y10T156/1052 , Y10T156/1082
摘要： A drip pan apparatus for a helicopter includes a frame and a drip pan. The frame is secured to a skirt on the airframe of the helicopter. The apparatus includes a drip pan for cooperation with a frame to cover an access opening to a transmission. The drip pan includes a substantially planar member of a fiber-reinforced composite and has a seal surface that is configured to cooperate with a seal surface of the frame. A seal member may be disposed between the substantially planar member and the frame to form a fluid-tight seal. The fiber-reinforced composite may be a carbon fiber-reinforced composite. A method of making the drip pan apparatus includes placing a plurality of sheets of an uncured fiber-reinforced composite material on one another to form an uncured stack. The uncured stack is then cured. A frame and a drip pan may be cut from the cured stack.
摘要翻译： 用于直升机的滴水盘装置包括框架和滴水盘。 框架固定在直升机的机身上的裙子上。 该装置包括与框架配合以覆盖变速器的进入开口的滴盘。 滴水盘包括纤维增强复合材料的基本平坦的构件，并且具有构造成与框架的密封表面配合的密封表面。 密封构件可以设置在基本平坦的构件和框架之间以形成流体密封。 纤维增强复合材料可以是碳纤维增强复合材料。 制造滴水盘装置的方法包括将多片未固化的纤维增强复合材料片彼此放置以形成未固化的叠层。 然后固化未固化的叠层。 可以从固化的堆叠中切割框架和滴盘。
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9.发明授权公开(公告)号：US07789913B2
公开(公告)日：2010-09-07
申请号：US11170577
申请日：2005-06-29
申请人： Keith Collins , Thomas G. Wilson , Jared Walkenhorst , Dennis Lee , Andrew Carter , John Pafford , Mark D. LoGuidice , Lance Middleton , Lawrence Boyd
发明人： Keith Collins , Thomas G. Wilson , Jared Walkenhorst , Dennis Lee , Andrew Carter , John Pafford , Mark D. LoGuidice , Lance Middleton , Lawrence Boyd
IPC分类号： A61F2/44
CPC分类号： A61F2/4657 , A61B17/70 , A61B17/8811 , A61B17/8827 , A61B2017/0256 , A61B2017/564 , A61F2/4611 , A61F2/4684 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61M29/02
摘要： A method for treating a diseased or damaged spinal disc comprises the steps of: (a) providing access to the nucleus pulposus through the annulus; (b) removing at least a portion of the nucleus pulposus to create an intradiscal space; determining the size of the intradiscal space; and (c) sealably introducing under pressure a curable biomaterial through the annulus directly into the intradiscal space. The method may include the additional steps of applying a force to distract the opposing vertebral bodies about the intradiscal space and then removing the distraction force after the biomaterial has cured. The step of determining the size of the intradiscal space may be accomplished by expanding a compliant balloon within the intradiscal space using a contrast medium capable of visualization under fluoroscopy. The curable material is sealably introduced through a vented needle inserted through the opening. The curable biomaterial is introduced until a quantity of the material flows into the vent.
摘要翻译： 用于治疗患病或损伤的椎间盘的方法包括以下步骤：（a）通过所述环提供进入髓核的通路; （b）去除髓核的至少一部分以产生椎间盘内空间; 确定椎间盘内空间的大小; 和（c）在压力下可密封地将可固化生物材料通过环形物直接引入椎间盘内空间。 该方法可以包括额外的步骤：施加力以分散相对的椎体围绕椎间盘内空间，然后在生物材料固化后去除牵引力。 确定椎间盘内空间大小的步骤可以通过使用能够在荧光透视下可视化的造影剂来扩展椎间盘内空间内的顺应气囊来实现。 可固化材料通过穿过开口插入的通气针密封地引入。 引入可固化的生物材料，直到一定量的材料流入通气口。
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10.发明授权公开(公告)号：US07722579B2
公开(公告)日：2010-05-25
申请号：US11170010
申请日：2005-06-29
申请人： Keith Collins , Lawrence Boyd , Andrew Carter , Dennis Lee , John Pafford , Jared Walkenhorst , Thomas G. Wilson , Mark D. LoGuidice , Lance Middlelton
发明人： Keith Collins , Lawrence Boyd , Andrew Carter , Dennis Lee , John Pafford , Jared Walkenhorst , Thomas G. Wilson , Mark D. LoGuidice , Lance Middlelton
IPC分类号： A61M25/00
CPC分类号： A61F2/4657 , A61B17/70 , A61B17/8811 , A61B17/8827 , A61B2017/0256 , A61B2017/564 , A61F2/4611 , A61F2/4684 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61M29/02
摘要： A vented needle assembly is provided for sealably injecting biomaterial into an intradiscal space interiorly of the annulus of a spinal disc and for providing an exhaust for the intradiscal space. The vented needle assembly comprises a compressible seal body for pressing against an outer surface of the annulus, and a needle extending through the seal. The needle may be configured to connect to a syringe for pressure injection of the biomaterial. The seal includes a vent extending therethrough with an opening for communication with the intradiscal space and an opening for the discharge of excess biomaterial filling the intradiscal space. A kit of parts is also provided for use in the treatment of a spinal disc, the kit comprising the vented needle assembly and an inflatable trial device. The trial device is removably introduced into the intradiscal space and inflated to determine the available size of the intradiscal space.
摘要翻译： 提供了一种排气针组件，用于将生物材料密封地注入椎间盘环的内部的椎间盘内空间，并为椎间盘内空间提供排气。 排气针组件包括用于压靠环形空间的外表面的可压缩密封体和延伸穿过密封件的针。 针可以被配置为连接到注射器以用于压力注射生物材料。 密封件包括通过其延伸的通气口，其具有用于与椎间盘内空间连通的开口和用于排出填充椎间盘内空间的多余生物材料的开口。 还提供了一套用于治疗脊椎盘的部件，该套件包括通气针组件和可充气试验装置。 试验装置可拆卸地引入椎间盘内空间并充气以确定椎间盘内空间的可用尺寸。
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