Benzimidazole vascular damaging agents
    51.
    发明申请
    Benzimidazole vascular damaging agents 失效
    苯并咪唑血管损伤剂

    公开(公告)号:US20060264492A1

    公开(公告)日:2006-11-23

    申请号:US11483639

    申请日:2006-07-11

    申请人: Peter Davis

    发明人: Peter Davis

    IPC分类号: A61K31/4184 C07D235/28

    摘要: Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula I wherein A represents a multi-substituted alkyl group or aromatic ring.

    摘要翻译: 提供由取代的5(6) - 取代的苯并咪唑-2-氨基甲酸酯组成的血管损伤剂。 这些试剂可用于制备用于治疗涉及新血管形成的疾病的药物,特别是用于治疗实体瘤,黄斑变性,糖尿病性视网膜病,类风湿性关节炎,牛皮癣和动脉粥样硬化。 实施方案包括式I的5(6) - 取代的苯并咪唑-2-氨基甲酸酯,其中A表示多取代的烷基或芳环。

    Bioreductively activated stilbene prodrugs
    52.
    发明申请
    Bioreductively activated stilbene prodrugs 审中-公开
    生物还原活化的二苯乙烯前药

    公开(公告)号:US20060223827A1

    公开(公告)日:2006-10-05

    申请号:US10550982

    申请日:2004-03-26

    CPC分类号: C07D333/44 C07D209/12

    摘要: A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3); R1 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R2 is alkyl, alkoxy, thialkoxy or halo; R3, R4 and R5 are each independently alkyl, alkoxy, thialkoxy or halo with the proviso that at least two of R3, R4 or R5 are alkoxy; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is O, S or NR7; Y is hydrogen, alkyl, alkoxy, thialkoxy, halo, hydroxy or dihydrogenphosphate; R6 is hydrogen or alkyl; R7 is hydrogen or alkyl; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; R10 is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11, and R12 are independently hydrogen, alkyl, alkoxy, thialkoxy, amono alkylamino, dialkylamino, morpholino, alkylmorpholino, piperidino, alkylpiperidiono, piperazino, alkylpiperazino or 1-aziridinyl; and A, together with the carbon atoms to which it is fused, is an optionally substituted aryl or heteroaryl ring.

    摘要翻译: 式(1)化合物或其药学上可接受的盐,其中Ar是带有至少一个硝基或叠氮基的取代杂芳基,或者是式(2)或(3)的基团。 R 1是氢,任选取代的烷基,任选取代的芳基或任选取代的杂芳基; R 2是烷基,烷氧基,硫烷氧基或卤素; R 3,R 4和R 5各自独立地为烷基,烷氧基,硫烷氧基或卤素,条件是R 3,R 4或R 5是烷氧基; L是-OC(O) - 或-OP(O)(OR 6) - ; n为0或1; X是O,S或NR 7; Y是氢,烷基,烷氧基,硫烷氧基,卤素,羟基或磷酸二氢酯; R 6是氢或烷基; R 7是氢或烷基; R 8是氢,烷氧基或二烷基氨基烷基; R 9是任选取代的烷基; R 10是氢,烷基,烷氧基或二烷基氨基烷基; R 11和R 12独立地是氢,烷基,烷氧基,硫烷氧基,氨基烷基氨基,二烷基氨基,吗啉代,烷基吗啉代,哌啶子基,烷基哌啶子基,哌嗪基,烷基哌嗪基或1-氮丙啶基 ; 和A与其稠合的碳原子一起是任选取代的芳基或杂芳基环。

    Method and apparatus for removing die from a wafer and conveying die to a pickup location
    53.
    发明授权
    Method and apparatus for removing die from a wafer and conveying die to a pickup location 有权
    用于从晶片去除模具并将模具输送到拾取位置的方法和装置

    公开(公告)号:US06173750B1

    公开(公告)日:2001-01-16

    申请号:US09251541

    申请日:1999-02-17

    IPC分类号: B32B3500

    摘要: A direct die feeder picks known good die from a wafer and places them on a conveyor belt, which conveys the die to a pickup location. Frame (111) supports a wafer (105) which is a wafer that is sawed while adhered onto a flexible film, which is then stretched and mounted in a ring (110). A fork member (125), on which a pick head (150) is mounted slides along a horizontal axis and frame (111) slides along a vertical axis to allow the pick head (150) to access any die from the wafer. A camera (160) is directed downward at a 45° mirror (162) adjacent to the pick head to capture images of the wafer and determine the precise locations of die and qualify them. The pick head (150) can pick die from the wafer and place them directly on the conveyor belt (170) in the conventional orientation, or pass the die to a flip head (140) which then shifts to the left and lowers the die down past the pick head, placing the die on the conveyor belt in the flipped orientation. The conveyor belt operates until a die is detected at a pickup location (173) at one end of the conveyor except during placing operations of the pick head or flip head or during burst mode operations, during which the conveyor belt is loaded with closely spaced die, then fed in rapid succession to a multi-head host pick and place machine.

    摘要翻译: 直接模具进料器从晶片上拾取已知的良好模具并将它们放置在传送带上,该输送带将模具传送到拾取位置。 框架(111)支撑晶片(105),其是在粘附到柔性膜上时被锯切的晶片,然后将其拉伸并安装在环(110)中。 其中安装有拾取头(150)的叉构件(125)沿着水平轴线滑动并且框架(111)沿着垂直轴线滑动以允许拾取头(150)从晶片进入任何管芯。 相机(160)向下指向与拾取头相邻的45°反射镜(162),以捕获晶片的图像并确定模具的精确位置并对其进行限定。 拾取头(150)可以从晶片上取出模具,并将它们以常规方向直接放置在传送带(170)上,或者将模具传递到翻转头(140),然后将翻转头向左移动并将模具降下 通过捡拾头,将模具放置在传送带上,翻转方向。 输送带工作直到在输送机的一端处的拾取位置(173)检测到模具,除了在拾取头或翻盖头的放置操作期间或在突发模式操作期间,输送带装载有紧密间隔的模具 ,然后快速连续送入多头主机拾放机。

    Traffic Control System, Congestion Control Method, Information Processing Apparatus, and Control Method and Storage Medium Therefor
    54.
    发明申请
    Traffic Control System, Congestion Control Method, Information Processing Apparatus, and Control Method and Storage Medium Therefor 审中-公开
    交通控制系统,拥塞控制方法,信息处理装置及其控制方法及存储介质

    公开(公告)号:US20140172521A1

    公开(公告)日:2014-06-19

    申请号:US14235444

    申请日:2012-07-26

    IPC分类号: G07B15/06

    摘要: A traffic control system (100) is provided with: a road information database (101) that accumulates road information including congestion degree; a reservation fee setter (102) that refers to the accumulated road information and sets a road passage reservation fee for a user; a reservation collector (103) that collects a road passage reservation from a user for the road passage reservation fee being set; and a congestion degree predictor (104) that predicts congestion degree of a road, including a user who passes without making a road passage reservation, by using information of the collected road passage reservation. The predicted congestion degree is used for alleviating congestion of a road.

    摘要翻译: 交通控制系统(100)具备:道路信息数据库(101),累积道路信息,包括拥挤度; 参考所累积的道路信息并为用户设定道路通行预约费的预约费设定者(102) 预约收集器(103),其从用户收集路段预约费用,设定路段预约费用; 以及拥挤度预测器(104),其通过使用所收集的道路通道预约的信息来预测包括通过而不进行道路通道预约的用户的道路的拥挤程度。 预测的拥挤度用于减轻道路拥堵。

    COMMUNICATION SUPPORT SYSTEM, COMMUNICATION SUPPORT METHOD, AND RECORDING MEDIUM
    56.
    发明申请
    COMMUNICATION SUPPORT SYSTEM, COMMUNICATION SUPPORT METHOD, AND RECORDING MEDIUM 有权
    通信支持系统,通信支持方法和记录媒体

    公开(公告)号:US20120331101A1

    公开(公告)日:2012-12-27

    申请号:US13520417

    申请日:2010-12-28

    IPC分类号: G06F15/16

    摘要: A communication information registering unit (11) acquires communication information that contains a sender, a receiver, and a sending time of information communicated between users that are communicating, and stores the communication information in a storage unit (12). A response time calculation unit (13) finds response time of the users from the communication information. A threshold value setting unit (14) finds a threshold value for determining the statuses of the users from distribution of frequencies of the response time. A current status determination unit (15) determines the status of a counterpart user from the response time by using the threshold value. A notification unit (16) notifies a user of the current status of its counterpart user.

    摘要翻译: 通信信息登记单元(11)获取包含在正在通信的用户之间传送的信息的发送者,接收者和发送时间的通信信息,并将通信信息存储在存储单元(12)中。 响应时间计算单元(13)从通信信息中发现用户的响应时间。 阈值设定单元(14)从响应时间的频率分布中求出用于确定用户状态的阈值。 当前状态确定单元(15)通过使用阈值从响应时间确定对方用户的状态。 通知单元(16)向用户通知其对方用户的当前状态。

    Predicting candidates using information sources
    58.
    发明授权
    Predicting candidates using information sources 有权
    使用信息源预测候选人

    公开(公告)号:US07953692B2

    公开(公告)日:2011-05-31

    申请号:US11952600

    申请日:2007-12-07

    IPC分类号: G06F17/00 G06F17/20 G06F17/18

    CPC分类号: G06F17/276

    摘要: Embodiments are configured to provide one or more candidates based in part on an input. In an embodiment, a system includes a prediction engine which can be configured to provide one or more ranked candidates using one or more configurable data sources and/or candidate providers. Each data source can be configured to include a candidate provider to predict and return predicted candidates. The prediction engine can use a predicted candidate to rank and return a ranked candidate to a user interface, process, or other application. In one embodiment, a computing device can include and use a prediction engine which can use a customized ranking component to rank and return ranked candidates based in part on a query type. The customized ranking component can use predicted candidates provided by one or more data sources and/or candidate providers when making a ranking determination.

    摘要翻译: 实施例被配置为部分地基于输入来提供一个或多个候选。 在一个实施例中,系统包括可以被配置为使用一个或多个可配置数据源和/或候选提供者来提供一个或多个排名候选的预测引擎。 每个数据源可以被配置为包括候选提供者来预测和返回预测的候选。 预测引擎可以使用预测的候选者将排名的候选者排序并返回给用户界面,处理或其他应用。 在一个实施例中,计算设备可以包括并使用预测引擎,其可以使用定制的排名组件来部分地基于查询类型来排序和返回排名的候选。 定制排名组件可以在进行排名确定时使用由一个或多个数据源和/或候选提供者提供的预测候选者。