摘要:
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula I wherein A represents a multi-substituted alkyl group or aromatic ring.
摘要:
A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3); R1 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R2 is alkyl, alkoxy, thialkoxy or halo; R3, R4 and R5 are each independently alkyl, alkoxy, thialkoxy or halo with the proviso that at least two of R3, R4 or R5 are alkoxy; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is O, S or NR7; Y is hydrogen, alkyl, alkoxy, thialkoxy, halo, hydroxy or dihydrogenphosphate; R6 is hydrogen or alkyl; R7 is hydrogen or alkyl; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; R10 is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11, and R12 are independently hydrogen, alkyl, alkoxy, thialkoxy, amono alkylamino, dialkylamino, morpholino, alkylmorpholino, piperidino, alkylpiperidiono, piperazino, alkylpiperazino or 1-aziridinyl; and A, together with the carbon atoms to which it is fused, is an optionally substituted aryl or heteroaryl ring.
摘要翻译:式(1)化合物或其药学上可接受的盐,其中Ar是带有至少一个硝基或叠氮基的取代杂芳基,或者是式(2)或(3)的基团。 R 1是氢,任选取代的烷基,任选取代的芳基或任选取代的杂芳基; R 2是烷基,烷氧基,硫烷氧基或卤素; R 3,R 4和R 5各自独立地为烷基,烷氧基,硫烷氧基或卤素,条件是R 3,R 4或R 5是烷氧基; L是-OC(O) - 或-OP(O)(OR 6) - ; n为0或1; X是O,S或NR 7; Y是氢,烷基,烷氧基,硫烷氧基,卤素,羟基或磷酸二氢酯; R 6是氢或烷基; R 7是氢或烷基; R 8是氢,烷氧基或二烷基氨基烷基; R 9是任选取代的烷基; R 10是氢,烷基,烷氧基或二烷基氨基烷基; R 11和R 12独立地是氢,烷基,烷氧基,硫烷氧基,氨基烷基氨基,二烷基氨基,吗啉代,烷基吗啉代,哌啶子基,烷基哌啶子基,哌嗪基,烷基哌嗪基或1-氮丙啶基 ; 和A与其稠合的碳原子一起是任选取代的芳基或杂芳基环。
摘要:
A direct die feeder picks known good die from a wafer and places them on a conveyor belt, which conveys the die to a pickup location. Frame (111) supports a wafer (105) which is a wafer that is sawed while adhered onto a flexible film, which is then stretched and mounted in a ring (110). A fork member (125), on which a pick head (150) is mounted slides along a horizontal axis and frame (111) slides along a vertical axis to allow the pick head (150) to access any die from the wafer. A camera (160) is directed downward at a 45° mirror (162) adjacent to the pick head to capture images of the wafer and determine the precise locations of die and qualify them. The pick head (150) can pick die from the wafer and place them directly on the conveyor belt (170) in the conventional orientation, or pass the die to a flip head (140) which then shifts to the left and lowers the die down past the pick head, placing the die on the conveyor belt in the flipped orientation. The conveyor belt operates until a die is detected at a pickup location (173) at one end of the conveyor except during placing operations of the pick head or flip head or during burst mode operations, during which the conveyor belt is loaded with closely spaced die, then fed in rapid succession to a multi-head host pick and place machine.
摘要:
A traffic control system (100) is provided with: a road information database (101) that accumulates road information including congestion degree; a reservation fee setter (102) that refers to the accumulated road information and sets a road passage reservation fee for a user; a reservation collector (103) that collects a road passage reservation from a user for the road passage reservation fee being set; and a congestion degree predictor (104) that predicts congestion degree of a road, including a user who passes without making a road passage reservation, by using information of the collected road passage reservation. The predicted congestion degree is used for alleviating congestion of a road.
摘要:
When wireless communications are made between a first wireless device and a second wireless device along a route, two wireless devices which exist between the first and second wireless devices each determine the lowest maximum transmission rate (11 Mbps) in the wireless intervals on the route from themselves to the second wireless device to be their own transmission rate txRate (11 Mbps) and two other wireless devices which exist between the first and second wireless devices each determine the lowest maximum transmission rate (54 Mbps) in the wireless intervals on the route from themselves to the second wireless device to be their own transmission rate txRate (54 Mbps).
摘要:
A communication information registering unit (11) acquires communication information that contains a sender, a receiver, and a sending time of information communicated between users that are communicating, and stores the communication information in a storage unit (12). A response time calculation unit (13) finds response time of the users from the communication information. A threshold value setting unit (14) finds a threshold value for determining the statuses of the users from distribution of frequencies of the response time. A current status determination unit (15) determines the status of a counterpart user from the response time by using the threshold value. A notification unit (16) notifies a user of the current status of its counterpart user.
摘要:
In wireless communication using links with neighbor wireless devices, a wireless device calculates ratios of throughput to maximum throughput for the links and calculates the costs of the links using the calculated ratios. Then the wireless device finds, for each destination, a route in which the sum of such calculated link costs is the minimum, and sends a packet to the destination using the route. As a consequence, routing can be done according to an isotonic, easy-to-implement routing protocol.
摘要:
Embodiments are configured to provide one or more candidates based in part on an input. In an embodiment, a system includes a prediction engine which can be configured to provide one or more ranked candidates using one or more configurable data sources and/or candidate providers. Each data source can be configured to include a candidate provider to predict and return predicted candidates. The prediction engine can use a predicted candidate to rank and return a ranked candidate to a user interface, process, or other application. In one embodiment, a computing device can include and use a prediction engine which can use a customized ranking component to rank and return ranked candidates based in part on a query type. The customized ranking component can use predicted candidates provided by one or more data sources and/or candidate providers when making a ranking determination.
摘要:
The route maintenance unit outputs a period setting request to the period setting unit when the communication unit normally receives a Hello packet for the first time. The period setting unit sets a link connection confirmation period in response to the period setting request and outputs the set period to the route maintenance unit. The route maintenance unit maintains a radio link between the radio device in which the route maintenance unit is provided and an adjacent device upon receiving a data packet other than a Hello packet from the adjacent radio device even if a Hello packet is not received in the link connection confirmation period. Consequently, route disconnection or switching occurs less often.
摘要:
A virtual private network device enables individual machines at a remote subnet to be visible and addressable from a central site by establishing a private address range for the remote machines, forming a virtual private network tunnel from the virtual private network device to the central site, and communicating the private address range to the central site to enable connections from the central site to individual machines on the remote subnet.