公开(公告)号：US20110004208A1

公开(公告)日：2011-01-06

申请号：US12605742

申请日：2009-10-26

申请人： Csaba Truckai ,  John Shadduck ,  James Baker

发明人： Csaba Truckai ,  John Shadduck ,  James Baker

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B17/32 ,  A61B2017/2945 ,  A61B2018/00619 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1432 ,  A61B2018/1495

摘要： Various embodiments provide an electrosurgical instrument with a disposable electrosurgical cartridge. In one embodiment, the cartridge has first and second energy-delivery surfaces that carry first and second opposing polarity conductors coupled to a voltage source, together with first and second temperature-responsive variable impedance bodies exposed partly in the respective-delivery surfaces. The cartridge further carries a slidable blade member. The temperature-responsive variable impedance bodies are coupled to the voltage source by series and parallel circuitry. In use, the variable impedance bodies are adapted to modulate current flow and ohmic heating in engaged tissue by providing controlled current paths in the tissue and through the variable impedance bodies as the temperature-responsive bodies sense the temperature of adjacent engaged tissue. The engagement surfaces are capable of highly localized modulation of Rf energy application to engaged tissue to provide high and low temperatures, voltage and current in the tissue to create high strength welds.

摘要翻译： 各种实施例提供具有一次性电外科手术盒的电外科器械。 在一个实施例中，盒具有第一和第二能量传递表面，其承载耦合到电压源的第一和第二相对极性导体以及部分地暴露在相应输送表面中的第一和第二温度响应可变阻抗体。 该盒还带有可滑动的刀片部件。 温度响应可变阻抗体通过串联和并联电路耦合到电压源。 在使用中，可变阻抗体适于通过在温度响应体感测相邻接合组织的温度时通过在组织中和通过可变阻抗体中提供受控的电流路径来调制接合组织中的电流和欧姆加热。 接合表面能够对接合组织进行Rf能量的高度局部调节，以在组织中提供高和低温度，电压和电流以产生高强度焊缝。

公开(公告)号：US20080070266A1

公开(公告)日：2008-03-20

申请号：US11827232

申请日：2007-07-11

申请人： Andrzej Myc ,  Istvan Majoros ,  Thommey Thomas ,  James Baker

发明人： Andrzej Myc ,  Istvan Majoros ,  Thommey Thomas ,  James Baker

IPC分类号： C12Q1/37 ,  C12Q1/02

CPC分类号： G01N33/542

摘要： The present invention relates to compositions comprising a FRET-based substrate, a cell-targeting moiety and a dendrimer, and methods for generating and using the same.

摘要翻译： 本发明涉及包含基于FRET的底物，细胞靶向部分和树枝状大分子的组合物及其生产和使用方法。

公开(公告)号：US20080069437A1

公开(公告)日：2008-03-20

申请号：US11898636

申请日：2007-09-13

申请人： James Baker

发明人： James Baker

IPC分类号： G06K9/62

CPC分类号： G06K9/6256 ,  G06K9/6262

摘要： A computer-implemented pattern recognition method, system and program product, the method comprising in one embodiment: creating electronically a linkage between a plurality of models within a classifier module within a pattern recognition system such that any one of said plurality of models may be selected as an active model in a recognition process; creating electronically a null hypothesis between at least one model of said plurality of linked models and at least a second model among said plurality of linked models; accumulating electronically evidence to accept or reject said null hypothesis until sufficient evidence is accumulated to reject said null hypothesis in favor of one of said plurality of linked models or until a stopping criterion is met; and transmitting at least a portion of the electronically accumulated evidence or a summary thereof to accept or reject said null hypothesis to a pattern classifier module.

摘要翻译： 一种计算机实现的模式识别方法，系统和程序产品，所述方法包括在一个实施例中：电子地创建模式识别系统内的分类器模块内的多个模型之间的链接，使得可以选择所述多个模型中的任何一个 作为识别过程中的积极模式; 在所述多个链接模型的至少一个模型和所述多个链接模型中的至少第二模型之间以电子方式创建零假设; 积累电子证据以接受或拒绝所述零假设，直到足够的证据被累积以拒绝所述零假设以有利于所述多个链接模型中的一个或直到满足停止标准为止; 以及传送所述电子累积证据的至少一部分或其摘要，以将所述零假设接受或拒绝给模式分类器模块。

公开(公告)号：US20070066063A1

公开(公告)日：2007-03-22

申请号：US11231249

申请日：2005-09-20

申请人： Anthony DiCarlo ,  Jingqiu Chen ,  Yanghua He ,  James Baker ,  David Rothenbury

发明人： Anthony DiCarlo ,  Jingqiu Chen ,  Yanghua He ,  James Baker ,  David Rothenbury

IPC分类号： H01L21/302

CPC分类号： G03F7/40 ,  G02B26/0841

摘要： The present invention provides a method for planarizing a metal layer, and a method for manufacturing a micro pixel array. The method for planarizing the metal layer, without limitation, may include the steps of forming a metal layer over a photoresist layer, and then planarizing the metal layer using a chemical mechanical planarization process.

摘要翻译： 本发明提供了一种用于平坦化金属层的方法和一种用于制造微像素阵列的方法。 用于平坦化金属层的方法，但不限于，可以包括在光致抗蚀剂层上形成金属层，然后使用化学机械平坦化工艺平坦化金属层的步骤。

公开(公告)号：US07186253B2

公开(公告)日：2007-03-06

申请号：US11118881

申请日：2005-04-29

申请人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John H. Shadduck

发明人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John H. Shadduck

IPC分类号： A61B18/14 ,  A61B18/12

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063 ,  A61B2018/00809

摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.

摘要翻译： 手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。 在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。 接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。 钳口的内部承载耦合到Rf源和控制器的导电材料或电极。 在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

公开(公告)号：US20070041934A1

公开(公告)日：2007-02-22

申请号：US11503742

申请日：2006-08-14

申请人： Bernell William ,  Rameshwer Shukla ,  James Baker

发明人： Bernell William ,  Rameshwer Shukla ,  James Baker

IPC分类号： A61K31/787 ,  G01N33/567 ,  C08G73/02

CPC分类号： C08G73/0206 ,  A61K31/787 ,  Y02A50/401 ,  Y02A50/465 ,  Y02A50/478

摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及用于疾病诊断和治疗（例如，癌症诊断和治疗）的基于树枝状大分子的组合物和系统。 组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的反应的一种或多种组分。

公开(公告)号：US20060184206A1

公开(公告)日：2006-08-17

申请号：US11058403

申请日：2005-02-15

申请人： Rex Baker ,  James Baker

发明人： Rex Baker ,  James Baker

IPC分类号： A61N1/378

CPC分类号： A61N1/3785

摘要： An implantable generating system includes a generator assembly for converting mechanical motion into electrical energy. A linkage assembly, which is mechanically coupled to the generator assembly, converts respiratory motion into mechanical motion.

摘要翻译： 可植入发电系统包括用于将机械运动转换为电能的发电机组件。 机械地联接到发电机组件的连杆组件将呼吸运动转换成机械运动。

公开(公告)号：US20060093953A1

公开(公告)日：2006-05-04

申请号：US10978703

申请日：2004-10-31

申请人： Charles Simpson ,  Ronald Moudry ,  James Baker

发明人： Charles Simpson ,  Ronald Moudry ,  James Baker

IPC分类号： G03G9/13

CPC分类号： G03G9/125 ,  G03G9/133 ,  G03G9/135

摘要： The invention provides liquid electrographic toner compositions comprising a liquid carrier having toner particles dispersed in the liquid carrier. The liquid carrier has a Kauri-Butanol number less than about 30 mL. The toner particles comprise polymeric binder comprising at least one amphipathic copolymer comprising one or more S material portions and one or more D material portions. The toner composition additionally comprises a dispersed wax component associated with the toner particle. These toner particles can exhibit excellent final image durability characteristics, and can also provide toner compositions that provide excellent images at low fusion temperatures on a final image receptor.

摘要翻译： 本发明提供液体电摄影调色剂组合物，其包括具有分散在液体载体中的调色剂颗粒的液体载体。 液体载体的贝壳胡丁醇数小于约30mL。 调色剂颗粒包含聚合物粘合剂，其包含至少一种包含一种或多种S材料部分和一种或多种D材料部分的两亲共聚物。 调色剂组合物另外包含与调色剂颗粒相关联的分散的蜡组分。 这些调色剂颗粒可以表现出优异的最终图像耐久性特征，并且还可以提供在最终图像受体的低熔融温度下提供优异图像的调色剂组合物。

公开(公告)号：US20060093948A1

公开(公告)日：2006-05-04

申请号：US10975527

申请日：2004-10-28

申请人： Susan Hill ,  Gay Herman ,  James Baker

发明人： Susan Hill ,  Gay Herman ,  James Baker

IPC分类号： G03G9/13

CPC分类号： G03G9/08797 ,  G03G9/08711 ,  G03G9/08722 ,  G03G9/08724 ,  G03G9/08728 ,  G03G9/08733 ,  G03G9/08782 ,  G03G9/08786 ,  G03G9/08788 ,  G03G9/08791 ,  G03G9/08795 ,  G03G9/125 ,  G03G9/131 ,  G03G9/133

摘要： The invention provides liquid electrographic toner compositions comprising a liquid carrier having toner particles and at least one soluble polymer dispersed in the liquid carrier. The liquid carrier has a Kauri-Butanol number less than about 30 mL. The toner particles comprise polymeric binder comprising at least one amphipathic copolymer comprising one or more S material portions and one or more D material portions. The soluble polymer is present in an amount of from about 1% to about 10% by weight based on toner particle weight. The absolute difference in Hildebrand solubility parameters between the soluble polymer and the liquid carrier is less than about 3.0 MPa1/2. In one aspect of the invention, the soluble polymer that is incorporated in the toner composition has no more than about 30% weight ratio chemical constitution variance from the chemical constitution of the S material portion of the amphipathic copolymer. In another aspect of the invention, the soluble polymer that is incorporated in the toner composition has no acidic functionality having a pKa greater than 8, and has no basic functionality having a pKa of its conjugate acid that is greater than 8. Methods of making these compositions are also provided.

摘要翻译： 本发明提供液体电摄影调色剂组合物，其包含具有调色剂颗粒和分散在液体载体中的至少一种可溶性聚合物的液体载体。 液体载体的贝壳胡丁醇数小于约30mL。 调色剂颗粒包含聚合物粘合剂，其包含至少一种包含一种或多种S材料部分和一种或多种D材料部分的两亲共聚物。 基于调色剂颗粒重量，可溶性聚合物的存在量为约1重量％至约10重量％。 可溶性聚合物和液体载体之间的希尔德布兰德溶解度参数的绝对差值小于约3.0MPa 1/2。 在本发明的一个方面，掺入调色剂组合物中的可溶性聚合物与两亲共聚物的S材料部分的化学构成不同于化学结构的30％重量比。 在本发明的另一方面，引入到调色剂组合物中的可溶性聚合物不具有pKa大于8的酸性官能团，并且不具有大于8的共轭酸的pKa的碱性官能度。制备这些 还提供了组合物。

公开(公告)号：US20060093945A1

公开(公告)日：2006-05-04

申请号：US10978911

申请日：2004-10-31

申请人： Eric Dalzell ,  Timothy Roberts ,  Susan Hill ,  Charles Simpson ,  James Baker

发明人： Eric Dalzell ,  Timothy Roberts ,  Susan Hill ,  Charles Simpson ,  James Baker

IPC分类号： G03G9/087

CPC分类号： G03G9/08708 ,  G03G9/0806 ,  G03G9/08711 ,  G03G9/08722 ,  G03G9/08724 ,  G03G9/08726 ,  G03G9/08728 ,  G03G9/08733 ,  G03G9/08755 ,  G03G9/08782 ,  G03G9/08786 ,  G03G9/08788 ,  G03G9/08791 ,  G03G9/08795 ,  G03G9/08797 ,  G03G9/09733 ,  G03G9/125 ,  G03G9/131 ,  G03G9/133 ,  G03G9/135 ,  G03G9/1355

摘要： A low temperature fusing dry electrographic toner composition has a plurality of dry toner particles, wherein the toner particles comprise polymeric binder comprising at least one amphipathic copolymer comprising one or more S material portions and one or more D material portions. The dry electrographic toner composition comprises a volatile plasticizer in an amount effective to reduce the First Heat Exposure Tg by at least about 10° C. as compared to a like electrographic toner composition that does not comprise volatile plasticizer. The plasticizer is sufficiently volatile that the Second Heat Exposure Tg will increase by at least about 5° C. above the First Heat Exposure Tg. Methods of making and of using these compositions are also provided.

摘要翻译： 低温熔化干电摄影调色剂组合物具有多个干调色剂颗粒，其中调色剂颗粒包含聚合物粘合剂，其包含至少一种包含一个或多个S材料部分和一个或多个D材料部分的两亲共聚物。 与不含挥发性增塑剂的类似电摄影调色剂组合物相比，干电摄影调色剂组合物包含有效量的第一热曝光度至少约10℃的挥发性增塑剂 。 增塑剂具有足够的挥发性，使得第二热处理暴露于第一热曝晒后将至少增加约5℃。 还提供了制备和使用这些组合物的方法。