公开(公告)号：US20110004208A1

公开(公告)日：2011-01-06

申请号：US12605742

申请日：2009-10-26

申请人： Csaba Truckai ,  John Shadduck ,  James Baker

发明人： Csaba Truckai ,  John Shadduck ,  James Baker

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B17/32 ,  A61B2017/2945 ,  A61B2018/00619 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1432 ,  A61B2018/1495

摘要： Various embodiments provide an electrosurgical instrument with a disposable electrosurgical cartridge. In one embodiment, the cartridge has first and second energy-delivery surfaces that carry first and second opposing polarity conductors coupled to a voltage source, together with first and second temperature-responsive variable impedance bodies exposed partly in the respective-delivery surfaces. The cartridge further carries a slidable blade member. The temperature-responsive variable impedance bodies are coupled to the voltage source by series and parallel circuitry. In use, the variable impedance bodies are adapted to modulate current flow and ohmic heating in engaged tissue by providing controlled current paths in the tissue and through the variable impedance bodies as the temperature-responsive bodies sense the temperature of adjacent engaged tissue. The engagement surfaces are capable of highly localized modulation of Rf energy application to engaged tissue to provide high and low temperatures, voltage and current in the tissue to create high strength welds.

摘要翻译： 各种实施例提供具有一次性电外科手术盒的电外科器械。 在一个实施例中，盒具有第一和第二能量传递表面，其承载耦合到电压源的第一和第二相对极性导体以及部分地暴露在相应输送表面中的第一和第二温度响应可变阻抗体。 该盒还带有可滑动的刀片部件。 温度响应可变阻抗体通过串联和并联电路耦合到电压源。 在使用中，可变阻抗体适于通过在温度响应体感测相邻接合组织的温度时通过在组织中和通过可变阻抗体中提供受控的电流路径来调制接合组织中的电流和欧姆加热。 接合表面能够对接合组织进行Rf能量的高度局部调节，以在组织中提供高和低温度，电压和电流以产生高强度焊缝。

公开(公告)号：US20050267464A1

公开(公告)日：2005-12-01

申请号：US10973818

申请日：2004-10-25

申请人： Csaba Truckai ,  John Shadduck ,  Bruno Strul ,  James Baker

发明人： Csaba Truckai ,  John Shadduck ,  Bruno Strul ,  James Baker

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B2018/00619

摘要： An embodiment of a method of the invention provides a method for welding tissue comprising providing a tissue welding device having first and second tissue engaging surfaces with at least one surface including an electrode surface that defines a plurality of surface portions having different resistances to electrical current flow therethrough. A target tissue volume is engaged with the tissue engaging surfaces. Rf energy is delivered to the target volume to create a substantially even temperature distribution across at least a portion of the target tissue volume to substantially uniformly weld at least a portion of the target tissue volume.

摘要翻译： 本发明的方法的一个实施例提供了一种焊接组织的方法，包括提供具有第一和第二组织接合表面的组织焊接装置，其中至少一个表面包括限定对电流流动具有不同电阻的多个表面部分的电极表面 通过。 目标组织体积与组织接合表面接合。 将Rf能量传递到目标体积以在目标组织体积的至少一部分上产生基本均匀的温度分布，以基本均匀地焊接目标组织体积的至少一部分。

公开(公告)号：US20050192568A1

公开(公告)日：2005-09-01

申请号：US11118881

申请日：2005-04-29

申请人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John Shadduck

发明人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John Shadduck

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063 ,  A61B2018/00809

摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.

摘要翻译： 手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。 在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。 接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。 钳口的内部承载耦合到Rf源和控制器的导电材料或电极。 在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

公开(公告)号：US07632269B2

公开(公告)日：2009-12-15

申请号：US11038930

申请日：2005-01-18

申请人： Csaba Truckai ,  John Shadduck ,  James Baker

发明人： Csaba Truckai ,  John Shadduck ,  James Baker

IPC分类号： A61B18/18

CPC分类号： A61B18/1442 ,  A61B17/32 ,  A61B2017/2945 ,  A61B2018/00619 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1432 ,  A61B2018/1495

摘要： An electrosurgical instrument with a disposable electrosurgical cartridge is provided. The cartridge has first and second energy-delivery surfaces that carry first and second opposing polarity conductors coupled to a voltage source, together with first and second temperature-responsive variable impedance bodies exposed partly in the respective-delivery surfaces. The cartridge further carries a slidable blade member. The temperature-responsive variable impedance bodies are coupled to the voltage source by series and parallel circuitry. In use, the variable impedance bodies are adapted to modulate current flow and ohmic heating in engaged tissue by providing controlled current paths in the tissue and through the variable impedance bodies as the temperature-responsive bodies sense the temperature of adjacent engaged tissue. The engagement surfaces are capable of highly localized modulation of Rf energy application to engage engaged tissue to provide high and low temperatures, voltage and current in the tissue to create high strength welds.

摘要翻译： 提供具有一次性电外科手术盒的电外科器械。 盒具有第一和第二能量传递表面，其承载耦合到电压源的第一和第二相对极性导体以及部分地暴露在相应输送表面中的第一和第二温度响应可变阻抗体。 该盒还带有可滑动的刀片部件。 温度响应可变阻抗体通过串联和并联电路耦合到电压源。 在使用中，可变阻抗体适于通过在温度响应体感测相邻接合组织的温度时通过在组织中和通过可变阻抗体中提供受控的电流路径来调制接合组织中的电流和欧姆加热。 接合表面能够高度局部调节Rf能量施加以接合啮合组织，以在组织中提供高温和低温，电压和电流以产生高强度焊缝。

公开(公告)号：US20050159745A1

公开(公告)日：2005-07-21

申请号：US11038930

申请日：2005-01-18

申请人： Csaba Truckai ,  John Shadduck ,  James Baker

发明人： Csaba Truckai ,  John Shadduck ,  James Baker

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B17/32 ,  A61B2017/2945 ,  A61B2018/00619 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1432 ,  A61B2018/1495

摘要： Various embodiments provide an electrosurgical instrument with a disposable electrosurgical cartridge. In one embodiment, the cartridge has first and second energy-delivery surfaces that carry first and second opposing polarity conductors coupled to a voltage source, together with first and second temperature-responsive variable impedance bodies exposed partly in the respective-delivery surfaces. The cartridge further carries a slidable blade member. The temperature-responsive variable impedance bodies are coupled to the voltage source by series and parallel circuitry. In use, the variable impedance bodies are adapted to modulate current flow and ohmic heating in engaged tissue by providing controlled current paths in the tissue and through the variable impedance bodies as the temperature-responsive bodies sense the temperature of adjacent engaged tissue. The engagement surfaces are capable of highly localized modulation of Rf energy application to engaged tissue to provide high and low temperatures, voltage and current in the tissue to create high strength welds.

摘要翻译： 各种实施例提供具有一次性电外科手术盒的电外科器械。 在一个实施例中，盒具有第一和第二能量传递表面，其承载耦合到电压源的第一和第二相对极性导体以及部分地暴露在相应输送表面中的第一和第二温度响应可变阻抗体。 该盒还带有可滑动的刀片部件。 温度响应可变阻抗体通过串联和并联电路耦合到电压源。 在使用中，可变阻抗体适于通过在温度响应体感测相邻接合组织的温度时通过在组织中和通过可变阻抗体中提供受控的电流路径来调制接合组织中的电流和欧姆加热。 接合表面能够对接合组织进行Rf能量的高度局部调节，以在组织中提供高和低温度，电压和电流以产生高强度焊缝。

公开(公告)号：US07186253B2

公开(公告)日：2007-03-06

申请号：US11118881

申请日：2005-04-29

申请人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John H. Shadduck

发明人： Csaba Truckai ,  James Baker ,  Bruno Strul ,  John H. Shadduck

IPC分类号： A61B18/14 ,  A61B18/12

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063 ,  A61B2018/00809

摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.

摘要翻译： 手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。 在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。 接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。 钳口的内部承载耦合到Rf源和控制器的导电材料或电极。 在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

公开(公告)号：US20080045942A1

公开(公告)日：2008-02-21

申请号：US11925092

申请日：2007-10-26

申请人： CSABA TRUCKAI ,  James Baker ,  John Shaddock

发明人： CSABA TRUCKAI ,  James Baker ,  John Shaddock

IPC分类号： A61B18/12

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063 ,  A61B2018/00654 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00809 ,  A61B2018/1467

摘要： An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a variable resistive body of a positive temperature coefficient material that has a selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The variable resistive body can be engineered to bracket a targeted thermal treatment range, for example about 60° C. to 80° C., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application across micron-scale portions of the engagement surface. In another mode of operation, a variable resistive body will focus conductive heating in a selected portion of the engagement surface.

摘要翻译： 一种用于在接合组织中产生热焊缝的电外科医疗装置和方法。 在一个实施例中，仪器的至少一个钳口限定了携带正温度系数材料的可变电阻体的组织接合平面，其在目标治疗范围内的每个选定的升高温度下具有选定的降低的电导率。 可变电阻体可以被设计成支撑目标热处理范围，例如约60℃至80℃，在该热处理范围内可以实现组织焊接。 在一种操作模式中，接合平面将自动地调节并且在接合表面的微米级部分的Rf能量施加之间空间地定位所接合组织内的欧姆加热。 在另一种操作模式中，可变电阻体将导电加热聚焦在接合表面的选定部分中。

公开(公告)号：US20070118109A1

公开(公告)日：2007-05-24

申请号：US11656062

申请日：2007-01-22

申请人： James Baker ,  John Shadduck

发明人： James Baker ,  John Shadduck

IPC分类号： A61B18/14 ,  A61F7/00 ,  A61F7/12

CPC分类号： A61B18/1485 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00505 ,  A61B2018/00553 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/126

摘要： Apparatus and methods for treating tissue at or near a sphincter provide for transluminal introduction of an energy delivery device. The device includes a tissue compression member to compress target tissue at or near the sphincter. A radiofrequency energy source is coupleable to the delivery device to deliver radiofrequency energy to the target tissue. Energy is delivered to heat the tissue to a desired temperature. The desired temperature is selected to induce an injury-healing response or to inducing shrinkage of collagen fibers in the target tissue to thereby reduce laxity in the target tissue.

公开(公告)号：US20130018776A1

公开(公告)日：2013-01-17

申请号：US13182228

申请日：2011-07-13

申请人： Jianjun Xie ,  Hoi-Ming Chi ,  Roger Noe ,  Mike Barnett ,  Brent Gaddis ,  James Baker

发明人： Jianjun Xie ,  Hoi-Ming Chi ,  Roger Noe ,  Mike Barnett ,  Brent Gaddis ,  James Baker

IPC分类号： G06Q40/02

CPC分类号： G06Q40/02

摘要： A method of income validation and evaluation for income risk assessment is disclosed in one embodiment. The method includes receiving a borrower loan request including a plurality of borrower data selected from the group consisting of: an employment type code, a borrower date-of-birth, a borrower zip code and a stated monthly income. The method further includes analyzing the received plurality of borrower data with respect to a stored plurality of borrower data to generate a normalized plurality of borrower data, implementing, if the stated monthly income is non-zero, an income fraud model utilizing at least the normalized plurality of borrower data including the employment type code, the borrower date-of-birth and the borrower zip code to determine an income fraud score based on the normalized plurality of borrower data, implementing an income estimation model utilizing at least the normalized plurality of borrower data and an age-band to determine a predicted income, and determining a risk assessment value as a function of the income fraud model and the income estimation mode.

摘要翻译： 在一个实施例中公开了收入风险评估的收入确认和评估方法。 该方法包括接收借款人贷款请求，其中包括从由以下各项组成的组中选择的多个借款人数据：雇佣类型代码，借款人出生日期，借款人邮政编码和所述月收入。 该方法还包括分析所接收的多个借款人数据相对于所存储的多个借款人数据以产生归一化的多个借款人数据，如果所述月收入不为零，则实施至少使用归一化的收入欺诈模型 多个借款人数据，包括就业类型代码，借款人出生日期和借款人邮政编码，以根据归一化的多个借款人数据确定收入欺诈分数，实施利用至少归一化的多个借款人的收入估计模型 数据和年龄段来确定预测收入，以及确定风险评估值作为收入欺诈模型和收入估计模式的函数。

公开(公告)号：US20120190124A1

公开(公告)日：2012-07-26

申请号：US13389625

申请日：2010-08-09

申请人： Mark Smith ,  Stephen Caddick ,  James Baker

发明人： Mark Smith ,  Stephen Caddick ,  James Baker

IPC分类号： C07K1/00 ,  C07D207/456 ,  C07K1/14 ,  C07D237/04 ,  G01N21/75 ,  C07K14/655 ,  C07D495/04

CPC分类号： C07K14/655 ,  A61K47/551 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0017 ,  C07D207/416 ,  C07D207/456 ,  C07D209/52 ,  C07K14/435 ,  G01N33/58 ,  Y02P20/55

摘要： The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

摘要翻译： 本发明涉及含有式（I）部分的化合物作为将包含式F1的第一功能部分的式R 1 -H的化合物与式F2的第二功能部分连接的试剂的用途，其中X， X'，Y，R1，F1和F2如本文所定义。 本发明还提供了相关的方法和产品。 本发明可用于产生功能性缀合化合物，特别是缀合物，其中至少一种构成分子携带巯基。