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    Simplified Approach for Service Composition and Orchestration
    51.
    发明申请
    Simplified Approach for Service Composition and Orchestration 审中-公开
    服务组合和编排的简化方法

    公开(公告)号：US20100262451A1

    公开(公告)日：2010-10-14

    申请号：US12423493

    申请日：2009-04-14

    申请人： Ali Bahrami ,  Jun Yuan

    发明人： Ali Bahrami ,  Jun Yuan

    IPC分类号： G06Q10/00 ,  G06F17/30

    CPC分类号： G06Q10/0633 ,  G06Q10/06

    摘要： The different advantageous embodiments provide a method, apparatus, and computer program product for improved workflow management. A workflow model is executed. The workflow model may include a number of worklets. Each worklet in the number of worklets may have a number of associated assistlets. A determination is made as to whether a number of associated assistelets for a first worklet in the number of worklets execute during execution of the workflow model. In response to a determination that the number of associated assistlets for the first worklet execute, the number of associated assistlets for the first worklet are executed.

    摘要翻译： 不同的有利实施例提供了用于改进的工作流管理的方法，装置和计算机程序产品。 执行工作流模型。 工作流模型可以包括多个工作单。 工作台数量上的每个工作台可能具有多个关联的辅助部件。 确定在工作流模型的执行期间是否在工作台数中执行用于第一工作台的多个关联的辅助工具的执行。 响应于确定第一工作台的相关联的辅助件的数量的执行，执行第一工件的相关联的辅助件的数量。

    Configuring or reconfiguring a multi-master information sharing environment
    52.
    发明授权
    Configuring or reconfiguring a multi-master information sharing environment 有权
    配置或重新配置多主信息共享环境

    公开(公告)号：US07702741B2

    公开(公告)日：2010-04-20

    申请号：US11831810

    申请日：2007-07-31

    申请人： Jun Yuan ,  Alan Downing ,  Lik Wong ,  Nimar Arora ,  Patricia H. McElroy ,  Byron Wang ,  Lei Gao ,  Anand Lakshminath ,  Ramkumar Venkatesan

    发明人： Jun Yuan ,  Alan Downing ,  Lik Wong ,  Nimar Arora ,  Patricia H. McElroy ,  Byron Wang ,  Lei Gao ,  Anand Lakshminath ,  Ramkumar Venkatesan

    IPC分类号： G06F15/173

    CPC分类号： G06F17/30575

    摘要： Configuring an n-way multi-master information sharing topology. Adding a new node (e.g., database server) to the information sharing topology can be implemented as follows. Initially, the new node is added as a slave of a particular co-master in the information sharing topology. The objects to replicate are instantiated on the new node by propagating data from the particular co-master to the new node. Furthermore, a capture process is created on the particular co-master to send changes to the objects to the slave. Meanwhile, the co-masters continue to propagate changes to each other. To promote the slave to a master, changes to objects stored at the slave are propagated to each of the co-masters. Furthermore, changes at each of the masters are propagated to the promoted node.

    摘要翻译： 配置n-way多主机信息共享拓扑。 将新节点（例如，数据库服务器）添加到信息共享拓扑可以如下实现。 最初，新的节点被添加为信息共享拓扑中特定共主机的从属。 通过将数据从特定共主机传播到新节点，将在新节点上实例化要复制的对象。 此外，在特定共同主机上创建捕获过程，以将对象的更改发送到从站。 同时，联合主人继续传播变化。 为了将从属设备升级到主设备，将存储在从站中的对象的更改传播到每个主站。 此外，每个主机的变化被传播到被推进的节点。

    Configuring or Reconfiguring a Multi-Master Information Sharing Environment
    53.
    发明申请
    Configuring or Reconfiguring a Multi-Master Information Sharing Environment 有权
    配置或重新配置多主信息共享环境

    公开(公告)号：US20090037553A1

    公开(公告)日：2009-02-05

    申请号：US11831810

    申请日：2007-07-31

    申请人： Jun Yuan ,  Alan Downing ,  Lik Wong ,  Nimar Arora ,  Patricia H. McElroy ,  Byron Wang ,  Lei Gao ,  Anand Lakshminath ,  Ramkumar Venkatesan

    发明人： Jun Yuan ,  Alan Downing ,  Lik Wong ,  Nimar Arora ,  Patricia H. McElroy ,  Byron Wang ,  Lei Gao ,  Anand Lakshminath ,  Ramkumar Venkatesan

    IPC分类号： G06F15/16

    CPC分类号： G06F17/30575

    摘要： Configuring an n-way multi-master information sharing topology. Adding a new node (e.g., database server) to the information sharing topology can be implemented as follows. Initially, the new node is added as a slave of a particular co-master in the information sharing topology. The objects to replicate are instantiated on the new node by propagating data from the particular co-master to the new node. Furthermore, a capture process is created on the particular co-master to send changes to the objects to the slave. Meanwhile, the co-masters continue to propagate changes to each other. To promote the slave to a master, changes to objects stored at the slave are propagated to each of the co-masters. Furthermore, changes at each of the masters are propagated to the promoted node.

    摘要翻译： 配置n-way多主机信息共享拓扑。 将新节点（例如，数据库服务器）添加到信息共享拓扑可以如下实现。 最初，新的节点被添加为信息共享拓扑中特定共主机的从属。 通过将数据从特定共主机传播到新节点，将在新节点上实例化要复制的对象。 此外，在特定共同主机上创建捕获过程，以将对象的更改发送到从站。 同时，联合主人继续传播变化。 为了将从属设备升级到主设备，将存储在从站中的对象的更改传播到每个主站。 此外，每个主机的变化被传播到被推进的节点。

    Bicyclic and tricyclic heteroaromatic compounds
    54.
    发明授权
    Bicyclic and tricyclic heteroaromatic compounds 失效
    双环和三环杂芳族化合物

    公开(公告)号：US07326709B2

    公开(公告)日：2008-02-05

    申请号：US11442812

    申请日：2006-05-30

    申请人： Jun Yuan ,  Pamela A. Albaugh ,  Kenneth Shaw ,  Alan J. Hutchison

    发明人： Jun Yuan ,  Pamela A. Albaugh ,  Kenneth Shaw ,  Alan J. Hutchison

    IPC分类号： C07D487/04 ,  A61K31/5025

    CPC分类号： C07D217/26 ,  C07D237/30 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  G01N2333/70571

    摘要： Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and are therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.

    摘要翻译： 公开了下式的化合物及其药学上可接受的盐，其中W，Q，X，X 1，Y和Z如本文所定义。 这些化合物以高选择性和/或高亲和力结合GABA A A受体的苯并二氮杂位点，因此可用于治疗中枢神经系统（CNS）疾病和用作GABA < 组织样品中的受体。 还公开了可用于制备这些化合物的中间体。

    Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
    58.
    发明申请
    Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands 审中-公开

    公开(公告)号：US20060142324A1

    公开(公告)日：2006-06-29

    申请号：US11355439

    申请日：2006-02-15

    申请人： Jun Yuan ,  George Maynard ,  Alan Hutchison

    发明人： Jun Yuan ,  George Maynard ,  Alan Hutchison

    IPC分类号： A61K31/4745 ,  C07D471/02

    CPC分类号： C07D471/04 ,  C07D495/04

    摘要： Disclosed are compounds of formula (I) or pharmaceutically acceptable non-toxic salts or pharmaceutically acceptable solvates thereof wherein: (II) represents (a), (b), (c) or (d) and W, X, Y, A, B, C, D, E are variables as described herein. These compounds are highly selective agonists or antagonists at NK3 receptors or prodrugs thereof. The novel tachykinin NK-3 receptor antagonists contained in this invention have potential utility in the treatment of a broad array of disorders and diseases of the central nervous system (CNS) and periphery in mammals in which activation of NK-3 receptors is of importance.

    System and method for multiple pass cooperative processing
    59.
    发明授权
    System and method for multiple pass cooperative processing 有权
    多通道协同处理系统和方法

    公开(公告)号：US07003512B1

    公开(公告)日：2006-02-21

    申请号：US10912174

    申请日：2004-08-06

    申请人： Jeffrey A. Bedell ,  William Hurwood ,  Benjamin Z. Li ,  Sadanand Sahasrabudhe ,  Xinyi Wang ,  Jun Yuan

    发明人： Jeffrey A. Bedell ,  William Hurwood ,  Benjamin Z. Li ,  Sadanand Sahasrabudhe ,  Xinyi Wang ,  Jun Yuan

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30595 ,  G06F17/30592 ,  G06Q10/10 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935

    摘要： A system for collaborative processing, comprising a controlling module with access to at least one relational database capable of performing a first set of functions on the data in the database and at least one external analytical engine, the external analytical engine being external to the relational database and being capable of a second set of functions on the data in the database. The controlling module is capable of iteratively processing a multi-step calculation including generating SQL statements to the relational database, passing preliminary results to an external analytical engine and saving data back into the relational database for further processing until the multi-step calculation is performed.

    摘要翻译： 一种用于协同处理的系统，包括控制模块，该控制模块可访问至少一个能够对数据库中的数据执行第一组功能的关系数据库和至少一个外部分析引擎，所述外部分析引擎在关系数据库外部 并且能够对数据库中的数据进行第二组功能。 控制模块能够迭代处理多步计算，包括生成SQL语句到关系数据库，将初步结果传递给外部分析引擎，并将数据保存回关系数据库进行进一步处理，直到执行多步计算。

    Antimicrobial theta defensins and methods of using same
    60.
    发明申请
    Antimicrobial theta defensins and methods of using same 审中-公开
    抗微生物θ防御素及其使用方法

    公开(公告)号：US20050261193A1

    公开(公告)日：2005-11-24

    申请号：US11126468

    申请日：2005-05-10

    申请人： Michael Selsted ,  Yi-Quan Tang ,  Jun Yuan ,  Andre Ouellette

    发明人： Michael Selsted ,  Yi-Quan Tang ,  Jun Yuan ,  Andre Ouellette

    IPC分类号： A61K38/00 ,  A61K38/10 ,  A61K38/12 ,  C07K7/08 ,  C07K14/47 ,  C12N15/12 ,  C12P21/00

    CPC分类号： C07K7/08 ,  A61K38/12 ,  C07K14/4723 ,  C12P21/00 ,  Y02A50/473 ,  Y02A50/481

    摘要： The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cy-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also relates to antibodies that specifically bind a theta defensin and to isolated nucleic acid molecules encoding a theta defensin. In addition, the invention relates to methods of using theta defensin or a theta defensin analog to reduce or inhibit microbial growth or survival in an environment capable of sustaining microbial growth or survival by contacting the environment with the theta defensin.

    摘要翻译： 本发明涉及具有抗微生物活性的分离的环肽，θ防御素，以及θ防御素类似物。 θ防御素可以具有氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa5，其中Xaa1至Xaa8是 定义 其中Xaa1可通过肽键与Xaa8连接; 并且其中可以在Xaa3和Xaa3之间，Xaa5和Xaa5之间以及Xaa7和Xaa7之间形成交联。 例如，本发明提供具有氨基酸序列Gly-Phe-Cy-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg的θ防御素 SEQ ID NO：1），其中位置1处的Gly（Gly-1）通过肽键与Arg-18连接，并且其中二硫键存在于Cys-3和Cys-16之间，Cys-5和Cys之间 -14，以及Cys-7和Cys-12之间。 本发明还涉及特异性结合θ防御素和编码θ防御素的分离的核酸分子的抗体。 此外，本发明涉及使用θ防御素或θ防御素类似物以通过使环境与θ防御素接触来在能够维持微生物生长或存活的环境中减少或抑制微生物生长或存活的方法。