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1.发明授权公开(公告)号：US07702741B2
公开(公告)日：2010-04-20
申请号：US11831810
申请日：2007-07-31
申请人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
发明人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
IPC分类号： G06F15/173
CPC分类号： G06F17/30575
摘要： Configuring an n-way multi-master information sharing topology. Adding a new node (e.g., database server) to the information sharing topology can be implemented as follows. Initially, the new node is added as a slave of a particular co-master in the information sharing topology. The objects to replicate are instantiated on the new node by propagating data from the particular co-master to the new node. Furthermore, a capture process is created on the particular co-master to send changes to the objects to the slave. Meanwhile, the co-masters continue to propagate changes to each other. To promote the slave to a master, changes to objects stored at the slave are propagated to each of the co-masters. Furthermore, changes at each of the masters are propagated to the promoted node.
摘要翻译： 配置n-way多主机信息共享拓扑。 将新节点（例如，数据库服务器）添加到信息共享拓扑可以如下实现。 最初，新的节点被添加为信息共享拓扑中特定共主机的从属。 通过将数据从特定共主机传播到新节点，将在新节点上实例化要复制的对象。 此外，在特定共同主机上创建捕获过程，以将对象的更改发送到从站。 同时，联合主人继续传播变化。 为了将从属设备升级到主设备，将存储在从站中的对象的更改传播到每个主站。 此外，每个主机的变化被传播到被推进的节点。
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2.发明申请公开(公告)号：US20090037553A1
公开(公告)日：2009-02-05
申请号：US11831810
申请日：2007-07-31
申请人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
发明人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
IPC分类号： G06F15/16
CPC分类号： G06F17/30575
摘要： Configuring an n-way multi-master information sharing topology. Adding a new node (e.g., database server) to the information sharing topology can be implemented as follows. Initially, the new node is added as a slave of a particular co-master in the information sharing topology. The objects to replicate are instantiated on the new node by propagating data from the particular co-master to the new node. Furthermore, a capture process is created on the particular co-master to send changes to the objects to the slave. Meanwhile, the co-masters continue to propagate changes to each other. To promote the slave to a master, changes to objects stored at the slave are propagated to each of the co-masters. Furthermore, changes at each of the masters are propagated to the promoted node.
摘要翻译： 配置n-way多主机信息共享拓扑。 将新节点（例如，数据库服务器）添加到信息共享拓扑可以如下实现。 最初，新的节点被添加为信息共享拓扑中特定共主机的从属。 通过将数据从特定共主机传播到新节点，将在新节点上实例化要复制的对象。 此外，在特定共同主机上创建捕获过程，以将对象的更改发送到从站。 同时，联合主人继续传播变化。 为了将从属设备升级到主设备，将存储在从站中的对象的更改传播到每个主站。 此外，每个主机的变化被传播到被推进的节点。
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公开(公告)号：US07899785B2
公开(公告)日：2011-03-01
申请号：US11831798
申请日：2007-07-31
申请人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
发明人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
IPC分类号： G06F17/30
CPC分类号： G06F17/30575
摘要： Splitting and merging database object information sharing streams. Streams are also referred to herein as “propagations”. Splitting and merging information sharing streams can be used to improve performance in a information sharing environment when a failed or slow DBS impacts the performance. In one embodiment, an auto split process monitors the progress of applying changes at each node and detects the presence of a failed or a slow node. Once the failed or slow node is identified, the auto split process splits the propagation such that the offending node is sent through a separate propagation. Furthermore, an auto merge process can be started to monitor the newly created separate propagation. At a later point, the new propagation can be merged back into the original stream. For example, if the offending node catches up with other nodes, the auto merge process merges the newly created propagation back to the original propagation.
摘要翻译： 分割和合并数据库对象信息共享流。 流在本文中也称为“传播”。 当失败或缓慢的DBS影响性能时，可以使用分割和合并信息共享流来提高信息共享环境中的性能。 在一个实施例中，自动拆分过程监视在每个节点处应用变化的进度，并检测故障或慢节点的存在。 一旦确定了故障或慢节点，自动拆分过程就会分裂传播，从而通过单独的传播发送违规节点。 此外，可以开始自动合并处理来监视新创建的单独传播。 稍后，新的传播可以合并回原始流。 例如，如果违规节点赶上其他节点，则自动合并过程将新创建的传播合并到原始传播。
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公开(公告)号：US20090037442A1
公开(公告)日：2009-02-05
申请号：US11831798
申请日：2007-07-31
申请人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
发明人： Jun Yuan , Alan Downing , Lik Wong , Nimar Arora , Patricia H. McElroy , Byron Wang , Lei Gao , Anand Lakshminath , Ramkumar Venkatesan
IPC分类号： G06F17/30
CPC分类号： G06F17/30575
摘要： Splitting and merging database object information sharing streams. Streams are also referred to herein as “propagations”. Splitting and merging information sharing streams can be used to improve performance in a information sharing environment when a failed or slow DBS impacts the performance. In one embodiment, an auto split process monitors the progress of applying changes at each node and detects the presence of a failed or a slow node. Once the failed or slow node is identified, the auto split process splits the propagation such that the offending node is sent through a separate propagation. Furthermore, an auto merge process can be started to monitor the newly created separate propagation. At a later point, the new propagation can be merged back into the original stream. For example, if the offending node catches up with other nodes, the auto merge process merges the newly created propagation back to the original propagation.
摘要翻译： 分割和合并数据库对象信息共享流。 流在本文中也称为“传播”。 当失败或缓慢的DBS影响性能时，可以使用分割和合并信息共享流来提高信息共享环境中的性能。 在一个实施例中，自动拆分过程监视在每个节点处应用变化的进度，并检测故障或慢节点的存在。 一旦确定了故障或慢节点，自动拆分过程就会分裂传播，从而通过单独的传播发送违规节点。 此外，可以开始自动合并处理来监视新创建的单独传播。 稍后，新的传播可以合并回原始流。 例如，如果违规节点赶上其他节点，则自动合并过程将新创建的传播合并到原始传播。
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公开(公告)号：US20080126354A1
公开(公告)日：2008-05-29
申请号：US11604529
申请日：2006-11-27
申请人： Byron Wang , Nimar Arora , Lik Wong , Jingwei Wu , Jun Yuan
发明人： Byron Wang , Nimar Arora , Lik Wong , Jingwei Wu , Jun Yuan
IPC分类号： G06F17/30
CPC分类号： G06F17/30575 , G06F11/3409 , G06F11/3452 , G06F11/3495 , G06F2201/80 , Y10S707/966
摘要： Systems, methodologies, media, and other embodiments associated with managing of a distributed database are described. One exemplary system embodiment includes an input logic configured to obtain information associated with a distributed database where the distributed database comprises a plurality of databases. An analysis logic analyzes the information obtained from the distributed database to determine performance information associated with the distributed database and, an output logic can provide information regarding the performance information associated with the distributed database.
摘要翻译： 描述了与分布式数据库的管理相关联的系统，方法，介质和其他实施例。 一个示例性系统实施例包括被配置为获得与分布式数据库相关联的信息的输入逻辑，其中分布式数据库包括多个数据库。 分析逻辑分析从分布式数据库获得的信息以确定与分布式数据库相关联的性能信息，并且输出逻辑可以提供关于与分布式数据库相关联的性能信息的信息。
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公开(公告)号：US07925674B2
公开(公告)日：2011-04-12
申请号：US11604529
申请日：2006-11-27
申请人： Byron Wang , Nimar Arora , Lik Wong , Jingwei Wu , Jun Yuan
发明人： Byron Wang , Nimar Arora , Lik Wong , Jingwei Wu , Jun Yuan
CPC分类号： G06F17/30575 , G06F11/3409 , G06F11/3452 , G06F11/3495 , G06F2201/80 , Y10S707/966
摘要： Systems, methodologies, media, and other embodiments associated with managing of a distributed database are described. One exemplary system embodiment includes an input logic configured to obtain information associated with a distributed database where the distributed database comprises a plurality of databases. An analysis logic analyzes the information obtained from the distributed database to determine performance information associated with the distributed database and, an output logic can provide information regarding the performance information associated with the distributed database.
摘要翻译： 描述了与分布式数据库的管理相关联的系统，方法，介质和其他实施例。 一个示例性系统实施例包括被配置为获得与分布式数据库相关联的信息的输入逻辑，其中分布式数据库包括多个数据库。 分析逻辑分析从分布式数据库获得的信息以确定与分布式数据库相关联的性能信息，并且输出逻辑可以提供关于与分布式数据库相关联的性能信息的信息。
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公开(公告)号：US07783601B2
公开(公告)日：2010-08-24
申请号：US11937414
申请日：2007-11-08
申请人： Lik Wong , Thuvan Hoang , Nimar Singh Arora , Jun Yuan
发明人： Lik Wong , Thuvan Hoang , Nimar Singh Arora , Jun Yuan
IPC分类号： G06F17/30
CPC分类号： G06F17/30566
摘要： In accordance with an embodiment of the present invention, a heterogeneous data sharing mechanism comprising a capture process and an apply process may be provided in a database system. The capture process mines or receives, at the source entity, a plurality of records that belong to a plurality of transactions. Here, first records from a first transaction in the plurality of transactions are interleaved with one or more records from one or more different transactions in the plurality of transactions. The capture process orders the plurality of records into a stream of ordered records such that all records that belong to a transaction are stored contiguously in a single block of records in the stream. Subsequently, the capture process sends the stream of ordered records from the source entity to the sink entity. Alternatively, the apply process retrieves the stream of ordered records from the capture process.
摘要翻译： 根据本发明的实施例，可以在数据库系统中提供包括捕获处理和应用处理的异构数据共享机制。 捕获过程在源实体上挖掘或接收属于多个事务的多个记录。 这里，来自多个事务中的第一事务的第一记录与来自多个事务中的一个或多个不同事务的一个或多个记录进行交织。 捕获过程将多个记录命令为有序记录流，使得属于事务的所有记录连续存储在流中的单个记录块中。 随后，捕获进程将有序记录流从源实体发送到汇点实体。 或者，应用进程从捕获进程检索有序记录流。
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公开(公告)号：US20090125563A1
公开(公告)日：2009-05-14
申请号：US11937414
申请日：2007-11-08
申请人： Lik Wong , Thuvan Hoang , Nimar Singh Arora , Jun Yuan
发明人： Lik Wong , Thuvan Hoang , Nimar Singh Arora , Jun Yuan
IPC分类号： G06F17/30
CPC分类号： G06F17/30566
摘要： In accordance with an embodiment of the present invention, a heterogeneous data sharing mechanism comprising a capture process and an apply process may be provided in a database system. The capture process mines or receives, at the source entity, a plurality of records that belong to a plurality of transactions. Here, first records from a first transaction in the plurality of transactions are interleaved with one or more records from one or more different transactions in the plurality of transactions. The capture process orders the plurality of records into a stream of ordered records such that all records that belong to a transaction are stored contiguously in a single block of records in the stream. Subsequently, the capture process sends the stream of ordered records from the source entity to the sink entity. Alternatively, the apply process retrieves the stream of ordered records from the capture process.
摘要翻译： 根据本发明的实施例，可以在数据库系统中提供包括捕获处理和应用处理的异构数据共享机制。 捕获过程在源实体上挖掘或接收属于多个事务的多个记录。 这里，来自多个事务中的第一事务的第一记录与来自多个事务中的一个或多个不同事务的一个或多个记录进行交织。 捕获过程将多个记录命令为有序记录流，使得属于事务的所有记录连续存储在流中的单个记录块中。 随后，捕获进程将有序记录流从源实体发送到汇点实体。 或者，应用进程从捕获进程检索有序记录流。
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公开(公告)号：US09683019B2
公开(公告)日：2017-06-20
申请号：US14963391
申请日：2015-12-09
申请人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
发明人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US09340582B2
公开(公告)日：2016-05-17
申请号：US14336290
申请日：2014-07-21
申请人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
发明人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , A61K47/542 , A61K47/643 , A61K47/68 , A61K47/6811 , C07K14/47 , C07K14/765 , C07K2319/30 , C07K2319/31
摘要： The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供包含式I'（SEQ ID NO：1）的合成多肽的生物缀合物或其酰胺，其酯或其盐，其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，X 8，X 9 ，X10，X11，X12和X13在本文中定义并且半衰期延长部分，其中肽和半衰期延长部分任选地经由连接体共价连接或融合。 多肽是APJ受体的激动剂。 本发明还涉及本发明的生物缀合物的制备方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，布鲁加达综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。
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