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公开(公告)号:US09707330B2
公开(公告)日:2017-07-18
申请号:US14240129
申请日:2012-08-22
申请人: Thomas D. Kelly , SuPing Lyu
发明人: Thomas D. Kelly , SuPing Lyu
CPC分类号: A61M1/1696 , A61M1/16 , A61M1/3609 , A61M2205/15 , A61M2205/3313 , A61M2205/3317 , A61M2205/50 , A61M2205/75 , A61M2209/082 , A61M2230/65 , B01D15/00 , B01D15/02 , B01D2313/44 , B01J20/0211 , B01J20/0292 , B01J20/20 , B01J20/24 , B01J2220/62
摘要: Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
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公开(公告)号:US08708946B2
公开(公告)日:2014-04-29
申请号:US13412249
申请日:2012-03-05
申请人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
发明人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
CPC分类号: A61M1/3669 , A61M1/30 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , Y10S439/909
摘要: An extracorporeal blood machine includes a blood circuit; an access device enabling the blood circuit to be connected to a patient; first and second coupling devices for connecting to first and second tubes of the circuit; first and second electrodes held by the first and second coupling devices to contact blood flowing through the blood circuit, the electrodes enabling an electrical signal to be injected into the circuit; first and second contact members contacting the first and second electrodes, wherein at least one of the coupling devices includes a stem portion enabling at least one of the first and second contact members to contact at least one of the first and second electrodes, respectively, on an outer portion of the at least one electrode without disturbing blood flowing through the coupling device; and electronics coupled operably to the first and second contact members for applying the electrical signal.
摘要翻译: 体外血液机器包括血液回路; 使得血液回路连接到患者的进入装置; 用于连接到电路的第一和第二管的第一和第二耦合装置; 由第一和第二耦合装置保持的第一和第二电极,以接触流过血液回路的血液,所述电极使得电信号被注入到电路中; 第一和第二接触构件与第一和第二电极接触,其中至少一个联接装置包括杆部分,使得第一和第二接触构件中的至少一个能够分别接触第一和第二电极中的至少一个, 所述至少一个电极的外部部分,而不扰动血液流过所述联接装置; 以及可操作地耦合到第一和第二接触构件的电子装置,用于施加电信号。
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公开(公告)号:US20120215151A1
公开(公告)日:2012-08-23
申请号:US13412249
申请日:2012-03-05
申请人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
发明人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
IPC分类号: A61M1/14
CPC分类号: A61M1/3669 , A61M1/30 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , Y10S439/909
摘要: An extracorporeal blood machine includes a blood circuit; an access device enabling the blood circuit to be connected to a patient; first and second coupling devices for connecting to first and second tubes of the circuit; first and second electrodes held by the first and second coupling devices to contact blood flowing through the blood circuit, the electrodes enabling an electrical signal to be injected into the circuit; first and second contact members contacting the first and second electrodes, wherein at least one of the coupling devices includes a stem portion enabling at least one of the first and second contact members to contact at least one of the first and second electrodes, respectively, on an outer portion of the at least one electrode without disturbing blood flowing through the coupling device; and electronics coupled operably to the first and second contact members for applying the electrical signal.
摘要翻译: 体外血液机器包括血液回路; 使得血液回路连接到患者的进入装置; 用于连接到电路的第一和第二管的第一和第二耦合装置; 由第一和第二耦合装置保持的第一和第二电极,以接触流过血液回路的血液,所述电极使得电信号被注入到电路中; 第一和第二接触构件与第一和第二电极接触,其中至少一个联接装置包括杆部分,使得第一和第二接触构件中的至少一个能够分别接触第一和第二电极中的至少一个, 所述至少一个电极的外部部分,而不扰动血液流过所述联接装置; 以及可操作地耦合到第一和第二接触构件的电子装置,用于施加电信号。
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公开(公告)号:US08137300B2
公开(公告)日:2012-03-20
申请号:US12727993
申请日:2010-03-19
申请人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
发明人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
CPC分类号: A61M1/3669 , A61M1/30 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , Y10S439/909
摘要: An extracorporeal blood system includes: an extracorporeal blood machine including an extracorporeal blood circuit; an access device enabling the extracorporeal blood circuit to be connected to a patient; first and second tube connecting members for connecting respectively to first and second tubes of the extracorporeal circuit; first and second electrodes held, at least in part, by the first and second tube connecting members so as to contact blood flowing through the extracorporeal blood circuit, the first and second electrodes enabling an electrical signal to be injected into the extracorporeal blood circuit; first and second contact members contacting the first and second electrodes respectively; and electronics coupled operably to the first and second contact members for applying the electrical signal, the signal used to monitor the access device.
摘要翻译: 体外血液系统包括:体外血液机器,包括体外血液回路; 允许体外血液回路连接到患者的进入装置; 第一和第二管连接构件,用于分别连接到体外回路的第一和第二管; 第一和第二电极至少部分地由第一和第二管连接构件保持以接触流过体外血液回路的血液,第一和第二电极能够将电信号注射到体外血液回路中; 分别与第一和第二电极接触的第一和第二接触构件; 以及可操作地耦合到第一和第二接触构件的电子装置,用于施加电信号,用于监测接入装置的信号。
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公开(公告)号:US07682328B2
公开(公告)日:2010-03-23
申请号:US11331609
申请日:2006-01-16
申请人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
发明人: James Han , Thomas P. Hartranft , Thomas D. Kelly , Angel Lasso
CPC分类号: A61M1/3669 , A61M1/30 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , Y10S439/909
摘要: An extracorporeal blood system includes: (i) an extracorporeal blood machine; an extracorporeal blood circuit coupled operably to the machine, the extracorporeal blood circuit including first and second blood lines, the blood lines configured to be in blood flow communication with a patient; (ii) an electrical loop including first and second electrodes placed in contact with blood flowing through the extracorporeal blood circuit; (iii) a device configured to inject an electrical signal into the blood circuit via the loop; and (iv) a third electrode placed in contact with blood flowing through the extracorporeal blood circuit, the third electrode configured to enable a change in an electrical value to be measured so that an access disconnection of the extracorporeal blood circuit from the patient can be measured.
摘要翻译: 体外血液系统包括:(i)体外血液机器; 体外血液循环,其可操作地耦合到所述机器,所述体外血液回路包括第一和第二血液线,所述血液线被配置为与患者血液流通; (ii)电回路,其包括与流过所述体外血液回路的血液接触的第一和第二电极; (iii)被配置为经由环路将电信号注入到血液回路中的装置; 以及(iv)与流过所述体外血液回路的血液接触的第三电极,所述第三电极被配置为能够测量要测量的电值的变化,从而可以测量体外血液回路与患者的进入断开 。
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公开(公告)号:US07303680B2
公开(公告)日:2007-12-04
申请号:US10461272
申请日:2003-06-13
申请人: Mark E. Connell , Robert A. Bedient , Raymond Elsen , Michael E. Hogard , Harley D. Johnson , Thomas D. Kelly , Jean McEvoy Long , Bruce A. Peterson , William G. Preston, Jr. , Dalibor J. Smejtek
发明人: Mark E. Connell , Robert A. Bedient , Raymond Elsen , Michael E. Hogard , Harley D. Johnson , Thomas D. Kelly , Jean McEvoy Long , Bruce A. Peterson , William G. Preston, Jr. , Dalibor J. Smejtek
IPC分类号: B01D61/32
CPC分类号: G06F3/04847 , A61M1/16 , A61M1/1607 , A61M1/1613 , A61M1/165 , A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/168 , A61M1/1684 , A61M1/1686 , A61M1/1688 , A61M1/169 , A61M1/1692 , A61M1/1694 , A61M1/341 , A61M1/3626 , A61M2039/1005 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3368 , A61M2205/505 , A61M2205/52 , G06F3/0482 , G06F19/00 , G06Q50/22 , G16H40/63 , Y10S210/929
摘要: A number of improvements relating to methods and apparatuses for kidney dialysis are disclosed. These include checking of dialysate bypass status using flow measurement; using a flow sensor to confirm the absence of ultrafiltration during bypass; automatic testing of ultrafiltration function by removal of a discrete volume from a portion of the dialysate flow path coupled with a pressure test of that part of the flow path; using a touch screen user interface; bar graph profile programming of ultrafiltration, sodium, and bicarbonate parameters; using a RAM card to upload treatment instructions to, and to download treatment data from, the machine; automatic setting of proportioning mode (acetate or bicarbonate) based on connections of concentrate lines; predicting dialysate conductivity values based on brand and formulation of concentrates; minimizing no-flow dead time between dialysate pulses; initiating operation in a timed mode from a machine power-off condition; preserving machine mode during machine power-fail condition; calibration scheduling and reminding; automatic level adjusting; and blood leak flow rate detecting.
摘要翻译: 公开了关于肾透析的方法和装置的许多改进。 这些包括使用流量测量检查透析液旁路状态; 使用流量传感器确认旁路过程中不存在超滤; 通过从与该流路的该部分的压力测试相结合的透析液流动路径的一部分去除离散体积来自动测试超滤功能; 使用触摸屏用户界面; 超滤,钠和碳酸氢盐参数的条形图配置文件; 使用RAM卡上传治疗指示,并从机器下载治疗数据; 基于浓缩液线的连接自动设定比例模式(乙酸盐或碳酸氢盐); 根据浓缩品牌和配方预测透析液电导率值; 减少透析脉冲之间的无流失死时间; 从机器关机状态开始定时模式运行; 机器停电时保存机器模式; 校准调度和提醒; 自动电平调节; 和血液泄漏流量检测。
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公开(公告)号:US5730712A
公开(公告)日:1998-03-24
申请号:US374485
申请日:1995-01-17
CPC分类号: B01D61/243 , A61M1/16 , A61M1/3427 , B01D61/32 , B01D63/02 , B01D63/04 , B01D2313/19
摘要: Dialyzers and methods are disclosed for performing shortened extracorporeal blood treatments. A flow restriction is provided in a dialyzer serving to partially impede flow of dialysate through the dialysate compartment of the dialyzer. As a result, the pressure of the dialysate upstream of the flow restriction is sufficient to cause the pressure profile of the dialysate from the dialysate inlet to the dialysate outlet of the dialyzer to be non-linear, in contrast to prior-art dialyzers. This perturbation of the dialysate pressure profile permits a single dialyzer to be used to remove large amounts of blood water from a patient's blood and re-infuse large amounts of liquid to the blood while still attaining a desired net ultrafiltration of the patient without the need for more than one dialyzer per treatment or for a separate replacement fluid.
摘要翻译: 透析器和方法被公开用于进行缩短的体外血液处理。 在透析器中提供流量限制,其用于部分阻止透析液流过透析器的透析液室。 结果,与现有技术的透析器相反,流量限制上游的透析液的压力足以使得透析液的压力分布从透析器的透析液入口到透析器的透析液出口是非线性的。 透析液压力曲线的这种扰动允许使用单一透析器从患者的血液中除去大量的血液,并将大量的液体重新注入到血液中,同时仍然达到患者的期望的净超滤,而不需要 每次治疗多于一个透析器或单独更换液体。
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公开(公告)号:US5247434A
公开(公告)日:1993-09-21
申请号:US688174
申请日:1991-04-19
申请人: Bruce A. Peterson , Michael E. Hogard , Harley D. Johnson , Thomas D. Kelly , Jean M. Long , William G. Preston, Jr.
发明人: Bruce A. Peterson , Michael E. Hogard , Harley D. Johnson , Thomas D. Kelly , Jean M. Long , William G. Preston, Jr.
CPC分类号: G06F3/0488 , A61M1/16 , A61M1/1607 , A61M1/1613 , A61M1/1639 , A61M1/165 , A61M1/1656 , A61M1/1662 , A61M1/169 , G06F3/0482 , A61M1/168 , A61M1/1692 , A61M1/1694 , A61M1/3626 , A61M2039/1005 , A61M2205/505 , A61M2205/52 , A61M2205/705
摘要: A number of improvements relating to methods and apparatuses for kidney dialysis are disclosed. These include checking of dialysate bypass status using flow measurement; using a flow sensor to confirm the absence of ultrafiltration during bypass; automatic testing of ultrafiltration function by removal of a discrete volume from a portion of the dialysate flow path coupled with a pressure test of that part of the flow path; using a touch screen user interface; bar graph profile programming of ultrafiltration, sodium, and bicarbonate parameters; using a RAM card to upload treatment instructions to, and to download treatment data from, the machine; automatic setting of proportioning mode (acetate or bicarbonate) based on connections of concentrate lines; predicting dialysate conductivity values based on brand and formulation of concentrates; minimizing no-flow dead time between dialysate pulses; initiating operation in a timed mode from a machine power-off condition; preserving machine mode during machine power-fail condition; calibration scheduling and reminding; automatic level adjusting; and blood leak flow rate detecting.
摘要翻译: 公开了关于肾透析的方法和装置的许多改进。 这些包括使用流量测量检查透析液旁路状态; 使用流量传感器确认旁路过程中不存在超滤; 通过从与该流路的该部分的压力测试相结合的透析液流动路径的一部分去除离散体积来自动测试超滤功能; 使用触摸屏用户界面; 超滤,钠和碳酸氢盐参数的条形图配置文件; 使用RAM卡上传治疗指示,并从机器下载治疗数据; 基于浓缩液线的连接自动设定比例模式(乙酸盐或碳酸氢盐); 根据浓缩品牌和配方预测透析液电导率值; 减少透析脉冲之间的无流失死时间; 从机器关机状态开始定时模式运行; 机器停电时保存机器模式; 校准调度和提醒; 自动电平调节; 和血液泄漏流量检测。
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