公开(公告)号：US06546269B1

公开(公告)日：2003-04-08

申请号：US09755528

申请日：2001-01-05

申请人： Ronald T. Kurnik

发明人： Ronald T. Kurnik

IPC分类号： A61B500

CPC分类号： A61B5/14532

摘要： A method and device are provided for measuring the concentration of target chemical analytes present in a biological system, and then predicting a future or past concentration of an analyte using a series of such measurements. One important application of the invention involves predicting future or past blood glucose concentrations using a series of measured blood glucose values.

摘要翻译： 提供了一种用于测量存在于生物系统中的目标化学分析物的浓度，然后使用一系列这样的测量来预测分析物的未来或过去浓度的方法和装置。 本发明的一个重要应用涉及使用一系列测量的血糖值来预测未来或过去的血糖浓度。

公开(公告)号：US06370410B2

公开(公告)日：2002-04-09

申请号：US09764550

申请日：2001-01-18

申请人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

发明人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

IPC分类号： A61B507

CPC分类号： A61B5/1486 ,  A61N1/30 ,  C12Q1/001 ,  C12Q1/002 ,  C12Q1/006

摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

摘要翻译： 化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。 掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输 基本上垂直于掩模的位置和工作电极的催化表面。 通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。 通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

公开(公告)号：US6139718A

公开(公告)日：2000-10-31

申请号：US824143

申请日：1997-03-25

申请人： Ronald T. Kurnik ,  Janet Tamada ,  Michael J. Tierney

发明人： Ronald T. Kurnik ,  Janet Tamada ,  Michael J. Tierney

IPC分类号： A61B5/0408 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1477 ,  C12Q1/54 ,  G01N27/30 ,  G01N27/327 ,  G01N27/26

CPC分类号： A61B5/1486 ,  C12Q1/54

摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.

摘要翻译： 公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，其由多个基本上分离的工作电极表面组成。 本发明的电极包括1）由多个工作电极表面或部件组成的工作电极，以及2）由相邻边缘限定的电绝缘间隙，1）将工作电极表面或部件彼此绝缘。 工作电极部件被配置成从两个或优选三个维度同时接收电化学信号。 配置在与单个电极相同的表面上的工作电极组件提供（1）通过降低噪声与单个电极相比提高了信噪比，以及（2）在感测到给定时间段之后提供总体增强的信号 。