公开(公告)号：US20170246191A1

公开(公告)日：2017-08-31

申请号：US15297845

申请日：2016-10-19

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Richard Thomas Beresis

IPC: A61K31/58 ,  A61K31/573

CPC classification number: A61K31/58 ,  A61K9/0019 ,  A61K31/573 ,  C07J1/0059 ,  C07J1/007 ,  C07J1/0074 ,  C07J3/00 ,  C07J5/0015 ,  C07J5/0053 ,  C07J7/00 ,  C07J7/002 ,  C07J7/007 ,  C07J7/0085 ,  C07J13/007 ,  C07J15/00 ,  C07J21/00 ,  C07J31/006 ,  C07J43/003

Abstract: Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

公开(公告)号：US20170233433A1

公开(公告)日：2017-08-17

申请号：US15519478

申请日：2015-10-16

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Francesco G. Salituro ,  Albert J. Robichaud ,  Boyd L. Harrison

IPC: C07J43/00 ,  A61K9/00 ,  A61K31/58

CPC classification number: C07J43/003 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/58 ,  A61P25/00 ,  C07D231/14 ,  C07D249/04 ,  C07D249/18 ,  C07D295/033

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R1, R2a, R2b, R3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20160031930A1

公开(公告)日：2016-02-04

申请号：US14775678

申请日：2014-03-13

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert J. Robichaud ,  Francesco G. Salituro

IPC: C07J9/00

CPC classification number: C07J9/00 ,  C07J9/005 ,  C07J13/005 ,  C07J13/007 ,  C07J21/008 ,  C07J41/0061

Abstract: (3alpha,3beta)-disubstituted 17beta steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.

Abstract translation: （3α，3β） - 二取代的17β甾体化合物及其药学上可接受的盐及其药物组合物，用于预防和治疗各种CNS相关病症。

公开(公告)号：US20240277733A1

公开(公告)日：2024-08-22

申请号：US18603816

申请日：2024-03-13

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella

IPC: A61K31/575 ,  C07J7/00 ,  C07J9/00

CPC classification number: A61K31/575 ,  C07J9/00 ,  C07J7/002 ,  C07J9/005

Abstract: Compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R6, R7, R8, and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US11993628B2

公开(公告)日：2024-05-28

申请号：US17242913

申请日：2021-04-28

Applicant: Sage Therapeutics, Inc.

Inventor： Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Boyd L. Harrison ,  Francesco G. Salituro ,  Andrew Griffin ,  Maria Jesus Blanco-Pillado

IPC: A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/20 ,  C07J1/00 ,  C07J7/00 ,  C07J41/00 ,  C07J43/00

CPC classification number: C07J43/003 ,  A61P25/00 ,  C07J1/0029 ,  C07J7/002 ,  C07J7/003 ,  C07J7/006 ,  C07J41/005 ,  C07J41/0094

Abstract: Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b, R12, R16, R17, R19, and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.

公开(公告)号：US20240132535A1

公开(公告)日：2024-04-25

申请号：US18216057

申请日：2023-06-29

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Boyd L. Harrison

IPC: C07J9/00 ,  A61P3/00 ,  A61P23/00 ,  A61P25/20 ,  C07J17/00

CPC classification number: C07J9/00 ,  A61P3/00 ,  A61P23/00 ,  A61P25/20 ,  C07J17/00 ,  C07J31/006

Abstract: Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, and R3 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US11905309B2

公开(公告)日：2024-02-20

申请号：US17381829

申请日：2021-07-21

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro

IPC: C07J9/00 ,  C07J13/00 ,  C07J21/00 ,  C07J41/00

CPC classification number: C07J9/00 ,  C07J9/005 ,  C07J13/005 ,  C07J13/007 ,  C07J21/008 ,  C07J41/0061

Abstract: 3beta, 17beta disubstituted steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.

公开(公告)号：US20230192757A1

公开(公告)日：2023-06-22

申请号：US18169964

申请日：2023-02-16

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Francesco G. Salituro ,  Albert Jean Robichaud ,  Boyd L. Harrison

IPC: C07J43/00 ,  C07D249/18 ,  C07D231/14 ,  C07D295/033 ,  C07D249/04 ,  A61P25/00 ,  C07J13/00 ,  C07J75/00 ,  A61K9/00 ,  A61K31/58

CPC classification number: C07J43/003 ,  C07D249/18 ,  C07D231/14 ,  C07D295/033 ,  C07D249/04 ,  A61P25/00 ,  C07J13/007 ,  C07J75/00 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/58

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R1, R2a, R2b, R3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US11498940B2

公开(公告)日：2022-11-15

申请号：US16843822

申请日：2020-04-08

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K31/58 ,  C07J7/00 ,  A61K45/06 ,  C07J21/00 ,  C07J1/00 ,  C07J13/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20220081465A1

公开(公告)日：2022-03-17

申请号：US17476153

申请日：2021-09-15

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Andrew Griffin ,  Boyd L. Harrison ,  Daniel La

IPC: C07J31/00 ,  C07J9/00

Abstract: Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.