公开(公告)号：US4127454A

公开(公告)日：1978-11-28

申请号：US826794

申请日：1977-08-22

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masashi Ukida

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masashi Ukida

IPC分类号： C07D277/80 ,  C25B3/10 ,  C25B3/02 ,  C07D277/60

CPC分类号： C07D277/80

摘要： Benzothiazolylsulfenamides are prepared in a high yield and substantially without a side reaction, via direct electrolytic oxidation, by cross-coupling (1) 2-mercaptobenzothiazole or dibenzothiazyl disulfide or an alkali metal salt of 2-mercaptobenzothiazole with (2) a primary or secondary amine, in the presence of a solvent selected from a dipolar aprotic solvent, a protic solvent, water and mixtures thereof, as well as a supporting electrolyte having adaptability to the solvent.

摘要翻译： 通过直接电解氧化，通过交联（1）2-巯基苯并噻唑或二苯并噻唑二硫化物或2-巯基苯并噻唑的碱金属盐与（2）伯胺或仲胺反应制备苯并噻唑亚磺酰胺 在选自偶极非质子溶剂，质子溶剂，水及其混合物的溶剂的存在下，以及对溶剂具有适应性的支持电解质。

公开(公告)号：US4898939A

公开(公告)日：1990-02-06

申请号：US316632

申请日：1989-02-28

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

IPC分类号： C07D499/87 ,  C07D499/00 ,  C07D499/86 ,  C07D499/897 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D499/00 ,  Y02P20/55

摘要： A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula ##STR1## wherein --N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R.sub.1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula ##STR2## wherein R.sub.1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula ##STR3## wherein ##STR4## is as defined above in the presence of a metal compound.

公开(公告)号：US4238615A

公开(公告)日：1980-12-09

申请号：US884222

申请日：1978-03-07

申请人： Sigeru Torii ,  Hideo Tanaka ,  Toshihiro Kudai

发明人： Sigeru Torii ,  Hideo Tanaka ,  Toshihiro Kudai

IPC分类号： C07C45/67 ,  C07D277/74 ,  C07D277/64

CPC分类号： C07D277/74 ,  C07C45/673

摘要： 2-Substituted-cyclopentanone derivatives represented by the formula ##STR1## are prepared by subjecting a 2-benzothiazolylsulfenamide derivative represented by the formula ##STR2## and cyclopentanone to condensation reaction, or by reacting the resulting condensation product with a hydrocarbon halide represented by the formulaR.sub.1 X.

摘要翻译： 由式“IMAGE”表示的2-取代的环戊酮衍生物是通过使由式＆lt; IMAGE＆gt;表示的2-苯并噻唑基亚磺酰胺衍生物和环戊酮进行缩合反应，或通过使所得缩合产物与由式 R1X。

公开(公告)号：US06339152B1

公开(公告)日：2002-01-15

申请号：US09380582

申请日：1999-09-07

申请人： Sigeru Torii ,  Hideo Tanaka ,  Yutaka Kameyama ,  Yoshihisa Tokumaru

发明人： Sigeru Torii ,  Hideo Tanaka ,  Yutaka Kameyama ,  Yoshihisa Tokumaru

IPC分类号： C07D49987

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up to −0.3 (V/SCE) in an amount of at least one mole per mole of the cephem compound and with a metal compound having a higher standard oxidation reduction potential than the metal and in an amount of 0.001 to 10 moles per mole of the cephem compound and wherein X is a halogen atom, lower alkylsulfonyloxy, trifluoromethanesulfonyloxy, trichloromethanesulfonyloxy, arylsulfonyloxy, toluenesulfonyloxy, or halogenated sulfonyloxy

摘要翻译： 本发明涉及一种制备外亚甲基环戊二烯化合物的方法，其中头孢烯化合物以至少为1摩尔量的标准氧化还原电位高达-0.3（V / SCE）的金属还原 和具有比金属高的标准氧化还原电位的金属化合物，并且每摩尔头孢烯化合物的量为0.001至10摩尔，其中X为卤素原子，低级烷基磺酰氧基，三氟甲磺酰氧基，三氯甲磺酰氧基， 芳基磺酰氧基，甲苯磺酰氧基或卤代磺酰氧基

公开(公告)号：US4891369A

公开(公告)日：1990-01-02

申请号：US123631

申请日：1987-11-23

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D499/44 ,  C07D499/86

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Disclosed are 2.beta.-substituted-methylpenicillanic acid compounds of the formula ##STR1## wherein n is 0, 1 or 2; and ##STR2## is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.These compounds are useful as .beta.-lactamase inhibitor.

公开(公告)号：US4120764A

公开(公告)日：1978-10-17

申请号：US869409

申请日：1978-01-16

申请人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

发明人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

IPC分类号： C25B3/02 ,  C07C155/10

CPC分类号： C25B3/02

摘要： A process for producing a tetraalkylthiuram disulfide which comprises electrolytically oxidizing a dialkylammonium dialkyldithiocarbamate having the formula ##STR1## wherein each R represents an alkyl group having from 1 to 4 carbon atoms, in the presence or absence of a supporting electrolyte to produce a tetraalkylthiuram disulfide, the electrolytic oxidation being carried out in one or more solvents which dissolve at least one of the starting dialkylammonium dialkyldithiocarbamate and the resulting tetraalkylthiuram disulfide.

摘要翻译： 一种生产四烷基秋兰姆二硫化物的方法，其包括电解氧化具有式“IMAGE”的二烷基二烷基二硫代氨基甲酸二烷基铵，其中每个R表示具有1至4个碳原子的烷基，在存在或不存在支持电解质的情况下，产生四烷基秋兰姆二硫化物， 电解氧化在一种或多种溶剂中进行，所述溶剂溶解起始二烷基二烷基二硫代氨基甲酸烷基酯和所得的四烷基秋兰姆二硫化物中的至少一种。

公开(公告)号：US07931782B2

公开(公告)日：2011-04-26

申请号：US10577510

申请日：2004-03-26

申请人： Sigeru Torii ,  Kouichi Miki

发明人： Sigeru Torii ,  Kouichi Miki

IPC分类号： B01D1/00 ,  B01D3/10 ,  B01D3/34 ,  B01D3/42 ,  B01D5/00

CPC分类号： B01D1/0047 ,  B01D1/0052 ,  B01D1/02 ,  B01D1/14 ,  B01D3/10 ,  B01D3/346 ,  B01D5/0063 ,  B01D5/009 ,  G01N2001/4066 ,  Y10S159/16 ,  Y10S159/901 ,  Y10S203/11

摘要： A method of recovering a liquid medium from a mixture containing the liquid medium, the method including: (a) blowing a first gas into the mixture containing the liquid medium to vaporize the liquid medium, in a first vaporizing means, thereby to form a second gas containing which is a mixture of the first gas and vaporized liquid medium; (b) continuously dropwise feeding the mixture containing the liquid medium into a second vaporizing means and counter-flowingly contacting the mixture containing the liquid medium, with the second gas to vaporize additional liquid medium to form a third gas which is a mixture of the second gas and additional vaporized liquid medium; and (c) feeding the third gas into a condensing means to condense the vaporized liquid medium into a liquid and separate the first gas, which is then blown into the first vaporizing means in step (a).

摘要翻译： 一种从含有液体介质的混合物中回收液体介质的方法，所述方法包括：（a）在第一蒸发装置中将第一气体吹入含有液体介质的混合物中以使液体介质蒸发，由此形成第二气体 含有第一气体和汽化液体介质的混合物的气体; （b）连续地将含有液体介质的混合物逐滴送入第二蒸发装置，并使包含液体介质的混合物与第二气体相反流接触，以蒸发附加的液体介质以形成第三气体，其是第二气体的混合物 气体和附加汽化液体介质; 和（c）将第三气体进料到冷凝装置中以将蒸发的液体介质冷凝成液体并分离第一气体，然后将其吹入步骤（a）中的第一蒸发装置。

公开(公告)号：US20080035467A1

公开(公告)日：2008-02-14

申请号：US10577510

申请日：2004-03-26

申请人： Sigeru Torii ,  Kouichi Miki

发明人： Sigeru Torii ,  Kouichi Miki

IPC分类号： B01D3/14 ,  B01D3/34

CPC分类号： B01D1/0047 ,  B01D1/0052 ,  B01D1/02 ,  B01D1/14 ,  B01D3/10 ,  B01D3/346 ,  B01D5/0063 ,  B01D5/009 ,  G01N2001/4066 ,  Y10S159/16 ,  Y10S159/901 ,  Y10S203/11

摘要： A method for recovering a liquid medium, comprising gas to be compulsorily contacted with the liquid medium to gasify the liquid medium, and condensing the gasified medium, and a device for recovering a liquid medium. Further, the present invention is directed to a device for recovering a liquid medium, wherein the device comprises: a gasifying means for bringing gas into contact with a mixed liquid comprising a liquid medium and a nonvolatile substance to gasify the liquid medium; a condensing-separating means for cooling the gas and the gasified medium fed from the gasifying means to separate the condensed medium from the separated gas; and a gas feeding means for feeding the separated gas as the gas to the gasifying means.

摘要翻译： 一种用于回收液体介质的方法，包括与液体介质强制接触的气体，以使液体介质气化，并冷凝气化介质，以及用于回收液体介质的装置。 此外，本发明涉及一种用于回收液体介质的装置，其中该装置包括：气体装置，用于使气体与包括液体介质和不挥发物质的混合液体接触，以使液体介质气化; 用于冷却气体的冷凝分离装置和从气化装置供给的气化介质，用于将冷凝介质与分离气体分离; 以及用于将分离的气体作为气体供给到气化装置的气体供给装置。

公开(公告)号：US4336202A

公开(公告)日：1982-06-22

申请号：US264463

申请日：1981-05-18

申请人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

发明人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

IPC分类号： C07C49/517 ,  C07D209/08 ,  C07D307/83 ,  C07C49/403

CPC分类号： C07D307/83 ,  C07C49/517 ,  C07D209/08

摘要： Novel cyclohexanone derivatives of general formula: ##STR1## (wherein R.sup.1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: ##STR2## (wherein R.sup.1 and R.sup.2 each is a hydrocarbon group of 1 to 15 carbon atoms) are produced by an electrooxidative coupling of 1,3-cyclohexanedione with a vinyl ether of general formula:CH.sub.2 .dbd.CH-O-R.sup.1(wherein R.sup.1 is as defined above) in the presence or absence of an alcohol of general formula:R.sup.2 OH(wherein R.sup.2 is as defined above). These new cyclohexanone derivatives can be easily converted to N-substituted or unsubstituted-4-oxo-4,5,6,7-tetrahydroindoles, which are of value as intermediates for the production of N-substituted or unsubstituted-4-hydroxyindoles and, thence, to pindolol and its analogs.

摘要翻译： 新型的通式为：IMA（其中R 1为1至15个碳原子的烃基）的环己酮衍生物和通式为新的环己酮衍生物：其中R1和R2各自为1至15个碳原子的烃基 原子）通过在通式R 2 OH的存在或不存在的情况下，通过1,3-环己二酮与通式为CH 2 = CH-O-R 1（其中R 1如上定义）的乙烯基醚的电氧偶合而产生 （其中R2如上所定义）。 这些新的环己酮衍生物可以容易地转化成N-取代或未取代的-4-氧代-4,5,6,7-四氢吲哚，它们作为制备N-取代或未取代的4-羟基吲哚的中间体， 因此，对吲哚洛尔及其类似物。