公开(公告)号：US20090004171A1

公开(公告)日：2009-01-01

申请号：US12101719

申请日：2008-04-11

Applicant: Masato Miyake ,  Yoshiji Fujita

Inventor： Masato Miyake ,  Yoshiji Fujita

IPC: A61K38/44 ,  C12Q1/68 ,  C40B30/06 ,  A61P35/00 ,  C12M1/34

CPC classification number: G01N33/5026 ,  C12Q1/6886 ,  C12Q2600/178 ,  G01N33/5011 ,  G16B5/00

Abstract: The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.

Abstract translation: 本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径 并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

公开(公告)号：US5143921A

公开(公告)日：1992-09-01

申请号：US533395

申请日：1990-06-04

Applicant: Koichi Kanehira ,  Katsushi Eziri ,  Manzo Shiono ,  Yoshiji Fujita ,  Johji Yamahara

Inventor： Koichi Kanehira ,  Katsushi Eziri ,  Manzo Shiono ,  Yoshiji Fujita ,  Johji Yamahara

IPC: C07D211/58 ,  C07D213/74 ,  C07D213/80 ,  C07D213/82 ,  C07D215/38 ,  C07D233/60 ,  C07D235/26 ,  C07D295/088 ,  C07D295/13 ,  C07D521/00

CPC classification number: C07D213/74 ,  C07D211/58 ,  C07D213/80 ,  C07D213/82 ,  C07D215/38 ,  C07D231/12 ,  C07D233/56 ,  C07D235/26 ,  C07D249/08 ,  C07D295/088 ,  C07D295/13

Abstract: Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.

Abstract translation: 提供具有抗过敏活性的新型萜烯氨基醇或改善脑功能的活性。 还提供了醇的药用。

公开(公告)号：US4886916A

公开(公告)日：1989-12-12

申请号：US168408

申请日：1988-03-15

Applicant: Takashi Onishi ,  Shigeaki Suzuki ,  Toshiki Mori ,  Hiroshi Fujii ,  Yoshiji Fujita

Inventor： Takashi Onishi ,  Shigeaki Suzuki ,  Toshiki Mori ,  Hiroshi Fujii ,  Yoshiji Fujita

IPC: C07C20060101 ,  C07C317/04 ,  C07C317/14

CPC classification number: C07C317/00

Abstract: A process for preparing an allylic sulfone of the following general formula (I), ##STR1## wherein, R is a hydrogen atom or a lower alkyl group, and containing both cis and trans isomers, by a reaction of a compound selected from the group consisting of geranyl chloride, neryl chloride, and linalyl chloride with a phenyl sulfinate of the following general formula (III), ##STR2## wherein, R is a hydrogen atom, or a lower alkyl group, and M is a sodium atom or potassium atom, in the presence of (i) tetralkylammonium iodide in an anhydrous condition or (ii) a zinc halide and an iodide.

公开(公告)号：US4827056A

公开(公告)日：1989-05-02

申请号：US164917

申请日：1988-03-07

Applicant: Shigeaki Suzuki ,  Toshiki Mori ,  Takashi Onishi ,  Yoshiji Fujita

Inventor： Shigeaki Suzuki ,  Toshiki Mori ,  Takashi Onishi ,  Yoshiji Fujita

IPC: C07C17/00 ,  C07C17/02 ,  C07C17/10 ,  C07C21/04 ,  C07C21/19 ,  C07C22/04 ,  C07C41/00 ,  C07C41/22 ,  C07C43/17 ,  C07C43/174 ,  C07C67/00 ,  C07C67/287 ,  C07C69/025

CPC classification number: C07C17/00 ,  C07C41/22 ,  C07C67/287 ,  C07C67/58

Abstract: Chlorinated olefins of general formula (I), ##STR1## wherein R is an alkyl, aralkyl, or alkenyl group substituted or not substituted by a lower acyloxy, lower alkyloxy, alkenyloxy or benzyloxy group, are prepared by the reaction of hypochlorous acid, generated by the reaction of sodium hypochlorite with a strong mineral acid, and olefins of general formula (II), ##STR2## wherein R is the same as defined above, in a two-phase system of water phase and organic solvent phase, not being miscible with water.

公开(公告)号：US4659510A

公开(公告)日：1987-04-21

申请号：US671194

申请日：1984-11-14

Applicant: Takashi Ohnishi ,  Shigeaki Suzuki ,  Yoshiji Fujita ,  Takashi Nishida

Inventor： Takashi Ohnishi ,  Shigeaki Suzuki ,  Yoshiji Fujita ,  Takashi Nishida

IPC: A23L27/29 ,  C07C45/51 ,  C07C45/72 ,  C07C49/573 ,  C11B9/00 ,  A61K7/46 ,  C07C49/21

CPC classification number: C11B9/0034 ,  A23L27/29 ,  C07C45/511 ,  C07C45/72 ,  C07C49/573

Abstract: Novel trimethylcyclohexenyl compounds of the 1,3,3-trimethyl-1-cyclohexene type having a 3-hydroxy-3-lower alkylpropionyl group at the 6-position of the cyclohexene are provided. These trimethylcyclohexenyl compounds have a floral note reminiscent of a variety of odors. There are also provided aroma compositions containing these compounds.

Abstract translation: 提供了在环己烯的6位具有3-羟基-3-低级烷基丙酰基的1,3,3-三甲基-1-环己烯型的新型三甲基环己烯化合物。 这些三甲基环己烯基化合物具有令人联想到各种气味的花香。 还提供含有这些化合物的香气组合物。

公开(公告)号：US4436939A

公开(公告)日：1984-03-13

申请号：US411481

申请日：1982-08-25

Applicant: Takehiro Amano ,  Kensei Yoshikawa ,  Tatsuhiko Sano ,  Yutaka Ohuchi ,  Michihiro Ishiguro ,  Manzo Shiono ,  Yoshiji Fujita ,  Takashi Nishida

Inventor： Takehiro Amano ,  Kensei Yoshikawa ,  Tatsuhiko Sano ,  Yutaka Ohuchi ,  Michihiro Ishiguro ,  Manzo Shiono ,  Yoshiji Fujita ,  Takashi Nishida

IPC: C07C27/00 ,  C07C29/40 ,  C07C33/30 ,  C07C67/00 ,  C07F3/02 ,  C07C33/28

CPC classification number: C07C29/40 ,  C07C33/30 ,  C07F3/02

Abstract: A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100.degree. C. and 150.degree. C. to form a Grignard reagent, and then reacting it with acetaldehyde.

Abstract translation: 一种生产1-（对异戊基苯基）乙醇的方法，其包括在100℃至150℃的温度下使对氯丙烯基苯与镁反应，形成格氏试剂，然后与乙醛反应。

公开(公告)号：US4433160A

公开(公告)日：1984-02-21

申请号：US411480

申请日：1982-08-25

Applicant: Takehiro Amano ,  Kensei Yoshikawa ,  Tatsuhiko Sano ,  Yutaka Ohuchi ,  Michihiro Ishiguro ,  Manzo Shiono ,  Yoshiji Fujita ,  Takashi Nishida

Inventor： Takehiro Amano ,  Kensei Yoshikawa ,  Tatsuhiko Sano ,  Yutaka Ohuchi ,  Michihiro Ishiguro ,  Manzo Shiono ,  Yoshiji Fujita ,  Takashi Nishida

IPC: C07C69/003 ,  B01J27/128 ,  B01J31/18 ,  C07B61/00 ,  C07C57/30 ,  C07C57/42 ,  C07C67/30 ,  C07C69/612 ,  C07D207/20 ,  C07D263/56 ,  C07D263/57 ,  C07D333/24 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052

CPC classification number: C07D263/57 ,  C07C57/30 ,  C07C57/42 ,  C07D207/20 ,  C07D333/24 ,  C07D471/04 ,  C07D491/04

Abstract: A process for producing an .alpha.-arylalkanoic acid ester represented by the general formula ##STR1## wherein Ar represents an aryl group which may optionally be substituted, and R.sup.1 and R.sup.2, independently from each other, represent a lower alkyl group,which comprises reacting a Grignard reagent prepared from an aryl halide of the general formulaAr--X.sup.1 (II)wherein Ar is as defined above and X.sup.1 represents a halogen atom,and magnesium, with an .alpha.-haloalkanoic acid ester of the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and X.sup.2 represents a halogen atom,said reaction of the Grignard reagent with the .alpha.-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.

Abstract translation: 制备由通式（I）表示的α-芳基链烷酸酯的方法，其中Ar表示可任意取代的芳基，R 1和R 2彼此独立地表示低级烷基，其中 包括使由通式Ar-X1（II）的芳基卤制得的格利雅试剂与其中Ar定义如上并且X1表示卤素原子的镁反应，与通式为“IMAGE”的α-卤代链烷酸酯反应， （III）其中R1和R2如上定义，X​​2表示卤素原子，所述格利雅试剂与通式（III）的α-卤代烷酸酯的反应在镍化合物的存在下进行。

公开(公告)号：USRE31330E

公开(公告)日：1983-08-02

申请号：US200087

申请日：1980-10-23

Applicant: Yoshiji Fujita ,  Yoshiaki Omura ,  Fumio Mori ,  Kazuo Itoi ,  Takashi Nishida ,  Yoshin Tamai ,  Sukeji Aihara ,  Takeo Hosogai ,  Fumio Wada

Inventor： Yoshiji Fujita ,  Yoshiaki Omura ,  Fumio Mori ,  Kazuo Itoi ,  Takashi Nishida ,  Yoshin Tamai ,  Sukeji Aihara ,  Takeo Hosogai ,  Fumio Wada

IPC: C07C17/00 ,  C07C17/10 ,  C07C17/25 ,  C07C17/278 ,  C07C17/35 ,  C07C17/358 ,  C07C17/361 ,  C07C21/02 ,  C07C21/04 ,  C07C29/62 ,  C07C31/36 ,  C07C43/12 ,  C07C43/174

CPC classification number: C07C21/04 ,  C07C17/00 ,  C07C17/10 ,  C07C17/25 ,  C07C17/278 ,  C07C17/35 ,  C07C17/358 ,  C07C17/361 ,  C07C21/02 ,  C07C29/62 ,  C07C31/36 ,  C07C43/12 ,  C07C43/174

Abstract: 1,1,1-Trihalogeno-4-methyl pentenes and 1,1-dihalogeno-4-methyl-1,3-pentadienes are produced. These compounds are of value as intermediates for the production of pyrethrin analogs which are of use as insecticides or agricultural chemicals.

公开(公告)号：US4315029A

公开(公告)日：1982-02-09

申请号：US128717

申请日：1980-03-10

Applicant: Fumio Mori ,  Yoshiaki Omura ,  Yoshiji Fujita ,  Takashi Nishida ,  Takeo Hosogai ,  Fumio Wada ,  Sukeji Aihara ,  Yoshin Tamai ,  Kazuo Itoi

Inventor： Fumio Mori ,  Yoshiaki Omura ,  Yoshiji Fujita ,  Takashi Nishida ,  Takeo Hosogai ,  Fumio Wada ,  Sukeji Aihara ,  Yoshin Tamai ,  Kazuo Itoi

IPC: A01N53/00 ,  A01N53/08 ,  C07C121/75

CPC classification number: A01N53/00

Abstract: Racemic modifications each consisting of specific isomers of .alpha.-cyano-3-phenoxybenzyl cis- or trans-2,2-dimethyl-3-(2,2,2-trichloroethyl)cyclopropanecarboxylate with the absolute configurations [.alpha.S, 1R] an [.alpha.R, 1S] with respect to the asymmetric carbon atoms in the alcohol and acid moieties, a method of producing the same and pesticidal compositions containing the same as active ingredient are provided. .alpha.-Cyano-3-phenoxybenzyl cis- or trans-2,2-dimethyl-3-(2,2,2-trichloroethyl)cyclopropanecarboxylate has higher pesticidal activities than those pesticides that are in general use and consequently selective production of the above specific racemic modification as defined by the combinations of the absolute configuration with respect to the asymmetric carbon atom at the position in the alcohol moiety and the absolute configuration with respect to the asymmetric carbon atom in the acid moiety provides compounds having still higher pesticidal activities.

Abstract translation: 由绝对构型[α，1R]代表的α-氰基-3-苯氧基苄基顺式或反式-2,2-二甲基-3-（2,2,2-三氯乙基）环丙烷羧酸酯的外消旋体改性， αR，1S]相对于醇和酸部分中的不对称碳原子，提供其制备方法和含有与活性成分相同的杀虫组合物。 环烷基-3-苯氧基苄基顺式或反式-2,2-二甲基-3-（2,2,2-三氯乙基）环丙烷羧酸酯的杀虫活性高于一般使用的农药，因此选择性地生产上述具体的 通过绝对构型相对于醇部分中位置上的不对称碳原子和相对于酸部分中的不对称碳原子的绝对构型的组合定义的外消旋改性提供具有更高杀虫活性的化合物。

公开(公告)号：US4303588A

公开(公告)日：1981-12-01

申请号：US132408

申请日：1980-03-21

Applicant: Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

Inventor： Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

IPC: A01N37/20 ,  A61K31/16 ,  A61K31/40 ,  A61K31/495 ,  A61P1/04 ,  C07C233/38 ,  C07D211/26 ,  C07D211/58 ,  C07D295/13 ,  C11C3/00 ,  C07D211/22

CPC classification number: C07D295/13 ,  C07D211/26 ,  C07D211/58

Abstract: Novel farnesylacetic acid amide compounds represented by general formula ##STR1## wherein A is alkylene of at least 2 carbon atoms, R.sup.1 is H or lower alkyl, and R.sup.2 and R.sup.3 are each independently H, alkyl, cycloalkyl, alkenyl, aryl or aralkyl, or either one of R.sup.2 and R.sup.3 is such a group that forms, together with A, a piperidine or pyrrolidine ring which contains as constituent thereof the nitrogen atom lying therebetween, or R.sup.2 and R.sup.3 combinedly represent a group which forms, together with the nitrogen atom to which they are bonded, a piperidine, pyrrolidine or piperazine ring; and salts thereof have antiulcerogenic and antibacterial activities.

Abstract translation: 由通式表示的新型法呢基酰胺化合物，其中A为至少2个碳原子的亚烷基，R 1为H或低级烷基，R 2和R 3各自独立地为H，烷基，环烷基，烯基，芳基或芳烷基，或 R 2和R 3中的任一个是与A一起形成哌啶或吡咯烷环的基团，其中含有位于其间的氮原子作为其组成，或者R 2和R 3组合地表示与氮原子一起形成的基团 它们是键合的，哌啶，吡咯烷或哌嗪环; 及其盐具有抗溃疡和抗菌活性。