公开(公告)号：US4895941A

公开(公告)日：1990-01-23

申请号：US316631

申请日：1989-02-28

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

IPC分类号： C07D499/87 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/86 ,  C07D499/861 ,  C07D499/897

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： 2.alpha.-Methyl-2.beta.-(1,2,3-triazol-1-yl)methylpenam-3.alpha.-carboxylic acid derivatives are prepared by reacting a penicillanic acid sulfoxide derivative of the formula ##STR1## wherein R is a penicillin carboxyl protecting group, and R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen, lower alkyl or the like with a triazole derivative of the formula ##STR2## wherein R.sub.3 and R.sub.4 are hydrogen, trialkylsilyl, lower alkyl, lower alkoxy or the like and R.sub.5 is hydrogen or silyl substituted with 3 groups selected from the class consisting of lower alkyl, benzyl and phenyl in a solvent.

公开(公告)号：US4891369A

公开(公告)日：1990-01-02

申请号：US123631

申请日：1987-11-23

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D499/44 ,  C07D499/86

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Disclosed are 2.beta.-substituted-methylpenicillanic acid compounds of the formula ##STR1## wherein n is 0, 1 or 2; and ##STR2## is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.These compounds are useful as .beta.-lactamase inhibitor.

公开(公告)号：US4898939A

公开(公告)日：1990-02-06

申请号：US316632

申请日：1989-02-28

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

IPC分类号： C07D499/87 ,  C07D499/00 ,  C07D499/86 ,  C07D499/897 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D499/00 ,  Y02P20/55

摘要： A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula ##STR1## wherein --N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R.sub.1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula ##STR2## wherein R.sub.1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula ##STR3## wherein ##STR4## is as defined above in the presence of a metal compound.

公开(公告)号：US4933444A

公开(公告)日：1990-06-12

申请号：US371230

申请日：1989-06-26

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D499/44 ,  C07D499/86

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Disclosed is a process for preparing 2.beta.-substituted-methylpenicillin derivative of the formula ##STR1## wherein R is H or carboxyl protecting group, R.sub.1 is H or halo, R.sub.2 is H, lower alkyl, lower alkoxy, halogen, azido, lower alkylthio, phthalimide or a group --NHR.sub.3 (wherein R.sub.3 is H or acyl), and --N Y is an optionally substituted monocyclic or bicyclic heterocyclic group having 1 to 4 nitrogen atoms in the ring structure, the process comprising reacting a compound of the formula ##STR2## wherein X is Cl or Br, and R, R.sub.1 and R.sub.2 are as defined above with a heterocyclic compound of the formula ##STR3## wherein --N Y is as defined above.

公开(公告)号：US4861768A

公开(公告)日：1989-08-29

申请号：US16114

申请日：1987-02-18

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

IPC分类号： C07D499/00 ,  C07D499/86

CPC分类号： C07D499/00

摘要： Disclosed is a penicillin derivative of the formula: ##STR1## wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, ##STR2## wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a phenyl group, a group --(CH.sub.2).sub.m --OR.sub.2 or --(CH.sub.2).sub.m COOR.sub.2 (m is an integer of 1 to 6 and R.sub.2 is a hydrogen atom or a penicillin carboxyl ester-forming group which is commonly used for penicillin derivatives) or a phenyl group substituted by at least one member selected from the class consisting of lower alkyl group, halogen atom and lower alkoxy group; and R is a hydrogen atom or a penicillin carboxyl ester-forming group, or a salt thereof. They are useful as .beta.-lactamase inhibitors.

摘要翻译： 公开了下式的青霉素衍生物：其中n是0,1或2的整数; Y是氰基，低级酰基，单 - 或二 - 低级烷硫基氨基甲酰基，其中R1是氢原子，低级烷基，苯基，基 - （CH2）m-OR2或 - （CH 2）m COOR 2（m为1〜6的整数，R2为氢原子或青霉素衍生物通常使用的青霉素羧酸酯形成基）或被选自上述的至少一种的苯基 由低级烷基，卤素原子和低级烷氧基组成; 和R是氢原子或青霉素羧酸酯形成基团或其盐。 它们可用作β-内酰胺酶抑制剂。

公开(公告)号：US4912213A

公开(公告)日：1990-03-27

申请号：US241186

申请日：1988-09-07

申请人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kase ,  Daisuke Suzuki ,  Shigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Akira Nakai

发明人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kase ,  Daisuke Suzuki ,  Shigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Akira Nakai

IPC分类号： C07D499/87 ,  B01J23/14 ,  B01J27/135 ,  C07B61/00 ,  C07D499/00 ,  C07D499/86 ,  C07D499/897

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.

公开(公告)号：US5728841A

公开(公告)日：1998-03-17

申请号：US637718

申请日：1996-04-30

申请人： Kazuhiko Shigeno ,  Tomoyasu Ono ,  Motoaki Tanaka ,  Shozo Yamada ,  Tetsuji Asao

发明人： Kazuhiko Shigeno ,  Tomoyasu Ono ,  Motoaki Tanaka ,  Shozo Yamada ,  Tetsuji Asao

IPC分类号： C07D249/04

CPC分类号： C07D249/04

摘要： This invention is to provide a process for preparing 1-amino-1,2,3-triazole represented by formula (III): ##STR1## comprising cyclizing glyoxal bishydrazone represented by formula (I): ##STR2## by reaction with an aqueous hydrogen peroxide solution in the presence of a catalytic amount of a transition metal oxide represented by formula (II): M.sub.m O.sub.n wherein M represents a transition metal atom; and m and n, which may be the same or different, each represent an integer of 1 to 5.

摘要翻译： PCT No.PCT / JP95 / 01727 Sec。 371日期：1996年04月30日 102（e）日期1996年4月30日PCT提交1995年8月30日PCT公布。 出版物WO96 / 06835 日本特开1996年3月7日本发明提供一种制备由式（III）表示的1-氨基-1,2,3-三唑的方法：包含使由式（I）表示的乙二醛双腙环化： 在催化量的由式（II）表示的过渡金属氧化物存在下，过氧化物溶液：MmOn其中M表示过渡金属原子; m和n可相同或不同，分别表示1〜5的整数。

公开(公告)号：US4826959A

公开(公告)日：1989-05-02

申请号：US150264

申请日：1988-01-29

申请人： Motoaki Tanaka ,  Tsutomu Miyagawa ,  Hideo Takeuchi

发明人： Motoaki Tanaka ,  Tsutomu Miyagawa ,  Hideo Takeuchi

IPC分类号： C07C67/00 ,  C07C253/00 ,  C07C255/04 ,  C07C255/65 ,  C08F4/04 ,  C08J9/06 ,  C08J9/10 ,  C07C107/00 ,  C07C107/02 ,  C07C107/04

CPC分类号： C07C255/65 ,  C08F4/04 ,  C08J9/102 ,  Y10S534/01

摘要： A mixture of an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a low melting point in an amount of about 70% by weight or more and an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a high melting point in an amount of about 30% by weight or less shows excellent solvent solubility, which is higher than that of the isomer having a low melting point. The mixture is useful as a polymerization initiator, and also as a blowing agent.

摘要翻译： 具有约70重量％以上的低熔点的2,2'-偶氮双（2,4-二甲基戊腈）的异构体和2,2'-偶氮双（2,4-二氯苯基） 具有约30重量％以下的高熔点的二甲基戊腈表现出优异的溶剂溶解度，其高于具有低熔点的异构体的溶解度。 该混合物可用作聚合引发剂，也可用作发泡剂。

公开(公告)号：US4777251A

公开(公告)日：1988-10-11

申请号：US43047

申请日：1987-04-27

申请人： Motoaki Tanaka ,  Tutomu Miyagawa ,  Iwao Takagishi

发明人： Motoaki Tanaka ,  Tutomu Miyagawa ,  Iwao Takagishi

IPC分类号： C09B47/067 ,  C09B67/50

CPC分类号： C09B67/0026 ,  C09B47/067

摘要： An improved process for preparing oxytitanium phthalocyanine is provided wherein the condensation reaction of o-phthalodinitrile with titanium tetrachloride is effected in an organic solvent at 170.degree. to 300.degree. C. followed by hydrolysis, the improvement wherein said organic solvent is preliminarily heated at a temperature of 160.degree. to 300.degree. C. prior to initiation of the condensation reaction. The A form of oxytitanium phthalocyanine crystal can selectively be produced in the pure state.

摘要翻译： 提供了一种制备氧钛酞菁的改进方法，其中邻苯二甲腈与四氯化钛的缩合反应在有机溶剂中在170℃至300℃下进行，然后进行水解，其改进在于所述有机溶剂在温度 在开始缩合反应之前为160℃至300℃。 氧化钛酞菁晶体的A形式可以选择性地以纯态生产。

公开(公告)号：US4399213A

公开(公告)日：1983-08-16

申请号：US312136

申请日：1981-10-16

申请人： Yoshikazu Watanabe ,  Motoaki Tanaka

发明人： Yoshikazu Watanabe ,  Motoaki Tanaka

IPC分类号： G03C1/32 ,  G03C1/38 ,  G03C1/76 ,  G03C1/78

CPC分类号： G03C1/7614 ,  G03C1/32 ,  G03C1/385 ,  Y10S430/142 ,  Y10S430/151

摘要： A silver halide photosensitive material comprising a support, a silver halide photosensitive layer, and a protective layer formed on said support. The protective layer is essentially composed on a plurality of non-photosensitive hydrophilic colloidal layers at least one of which contains oil particles. The outermost layer of the hydrophilic colloidal layers contains a matting agent in the form of colloidal particles and has a thickness of not more than one fourth of the average size of the matting agent particles and wherein the density of the oil particles in said outermost layer does not exceed 0.2 by volume of the binder, and that of the oil particles in the protective layers other than the outermost layer is in the range of 0.1 to 0.8.

摘要翻译： 一种卤化银感光材料，其包括载体，卤化银感光层和形成在所述载体上的保护层。 保护层基本上由多个非感光亲水性胶体层构成，其中至少一个含有油颗粒。 亲水性胶体层的最外层含有胶体颗粒形式的消光剂，其厚度不超过消光剂颗粒的平均尺寸的四分之一，其中所述最外层中的油颗粒的密度为 不超过粘合剂体积的0.2体积，除了最外层以外的保护层中的油粒子的比例在0.1〜0.8的范围内。