公开(公告)号：US10137316B2

公开(公告)日：2018-11-27

申请号：US14952817

申请日：2015-11-25

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  A61N5/10 ,  A61B6/02

Abstract: The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session.

公开(公告)号：US20160250501A1

公开(公告)日：2016-09-01

申请号：US14952817

申请日：2015-11-25

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/02

CPC classification number: A61N5/1069 ,  A61B6/02 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session.

公开(公告)号：US08975600B2

公开(公告)日：2015-03-10

申请号：US13789235

申请日：2013-03-07

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04 ,  A61N5/10 ,  A61B6/03 ,  A61B6/00

CPC classification number: A61N5/1039 ,  A61B5/0878 ,  A61B6/032 ,  A61B6/4092 ,  A61B6/4258 ,  A61B6/541 ,  A61B2560/0252 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1048 ,  A61N5/1068 ,  A61N5/107 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/08 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

Abstract translation: 本发明涉及一种用于控制带电粒子癌症治疗系统的方法和装置。 治疗传递控制系统用于直接控制癌症治疗系统的多个子系统，而不选择子系统之间的直接通信，这增强了安全性，简化了质量保证和质量控制，并且有助于编程。 例如，处理递送控制系统直接控制成像系统，定位系统，注射系统，射频四极杆系统，环形加速器或同步加速器，提取系统，束线，照射中的一个或多个 喷嘴，龙门架，显示系统，瞄准系统和验证系统。 通常，控制系统集成子系统和/或将上述癌症治疗系统元件中的一个或多个的输出与上述癌症治疗系统元件中的一个或多个的输入集成。

公开(公告)号：US08963112B1

公开(公告)日：2015-02-24

申请号：US14047807

申请日：2013-10-07

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  A61N5/10

CPC classification number: A61N5/1049 ,  A61N5/1037 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle radiation therapy. Patient positioning constraints optionally include one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are preferably movable and/or under computer control for rapid positioning, repositioning, and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the charged particle beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与多轴带电粒子放射治疗结合使用的患者定位和/或重新定位系统，例如铺设，半垂直或就座的患者定位，对准和/或控制方法和装置。 患者定位限制可选地包括以下中的一个或多个：座椅支撑件，后支撑件，头部支撑件，臂支撑件，膝盖支撑件和脚支撑件。 一个或多个定位限制优选地可移动和/或在计算机控制下进行，用于快速定位，重新定位和/或固定患者。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制带电粒子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US20140330063A1

公开(公告)日：2014-11-06

申请号：US13887339

申请日：2013-05-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/107 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，描述了用于向肿瘤有效辐射剂量递送的方法和装置。 优选地，辐射通过入口点输送到肿瘤中，并且布拉格峰值能量靶向肿瘤的远端或远侧与进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 光束强度与辐射剂量传递效率成正比。 具有针对每个照射方向的肿瘤远侧的能级的多场照射过程提供均匀且有效的带电粒子辐射剂量递送至肿瘤。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。

公开(公告)号：US08637833B2

公开(公告)日：2014-01-28

申请号：US13196720

申请日：2011-08-02

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle cancer therapy system or synchrotron system using a single power supply electrically connected to a plurality of magnet sections to provide a uniform current to a plurality of magnets at a given period in time. Optionally, one or more switches introduce a corresponding one or more resistors into a circuit linking the power supply to a magnet or an inductor during an applied power recovery phase between acceleration cycles of the synchrotron, which reduces time of reduction in power from an active applied power to a power suitable for use with a subsequent injection of charged particles into the synchrotron.

Abstract translation: 本发明包括带电粒子癌症治疗系统或同步加速器系统，其使用电连接到多个磁体部分的单个电源，以在给定的时间段内向多个磁体提供均匀的电流。 可选地，一个或多个开关将相应的一个或多个电阻器引入到在同步加速器的加速循环之间的施加的功率恢复阶段期间将电源连接到磁体或电感器的电路中，从而减少来自主动施加的功率的时间 功率适用于随后将带电粒子注入同步加速器中的功率。

公开(公告)号：US08614429B2

公开(公告)日：2013-12-24

申请号：US12714504

申请日：2010-02-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention relates to method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.

Abstract translation: 本发明涉及治疗实体癌的方法和装置。 更具体地，本发明包括多轴和/或多场带电粒子癌症治疗系统。 系统独立地控制患者平移位置，患者旋转位置，二维束轨迹，递送的束能，递送的束强度，带电粒子传递的时间和/或辐射进入健康组织的分布。 该系统与负离子束源，同步加速器，患者定位，成像和/或靶向方法和装置一起操作，以在分布辐射进入健康组织的同时向肿瘤递送有效且均匀的辐射。

公开(公告)号：US08581215B2

公开(公告)日：2013-11-12

申请号：US13481923

申请日：2012-05-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N5/1048 ,  A61N5/1067 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H13/04

Abstract: The invention comprises a patient positioning method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The patient positioning system is used to translate the patient and/or rotate the patient into a zone where the proton beam can scan the tumor using a targeting system. The patient positioning system is optionally used in conjunction with systems used to constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的患者定位方法和装置。 患者定位系统用于翻译患者和/或将患者旋转到质子束可以使用靶向系统扫描肿瘤的区域。 患者定位系统可选地与用于限制患者的运动的系统结合使用，例如半垂直，坐着或铺设定位系统。

公开(公告)号：US08436327B2

公开(公告)日：2013-05-07

申请号：US12636745

申请日：2009-12-13

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N5/1043 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H13/04

Abstract: The invention relates to treatment of solid cancers. More particularly, the invention relates to a combined rotation/raster method, referred to as multi-field charged particle cancer therapy. The system uses a fixed orientation proton source relative to a rotating patient to yield tumor irradiation from multiple directions. The system combines layer-wise tumor irradiation from many directions with controlled energy proton irradiation to deliver peak proton beam energy within a selected tumor volume or irradiated slice. Optionally, the selected tumor volume for irradiation from a given angle is a distal portion of the tumor. In this manner ingress Bragg peak energy is circumferentially spread about the tumor minimizing damage to healthy tissue and peak proton energy is efficiently, accurately, and precisely delivered to the tumor.

Abstract translation: 本发明涉及治疗固体癌症。 更具体地，本发明涉及称为多场带电粒子癌症治疗的组合旋转/光栅方法。 该系统相对于旋转患者使用固定取向质子源，以从多个方向产生肿瘤辐射。 该系统将来自多个方向的层次肿瘤照射与受控能量质子照射组合，以在选定的肿瘤体积或照射切片内提供峰值质子束能量。 任选地，用于从给定角度照射的所选择的肿瘤体积是肿瘤的远端部分。 以这种方式，入射布拉格峰能量围绕肿瘤周向扩散，使对健康组织的损伤最小化，并且峰值质子能量被有效，精确和准确地递送到肿瘤。

公开(公告)号：US20130105702A1

公开(公告)日：2013-05-02

申请号：US13282135

申请日：2011-10-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/34 ,  H01J3/20

CPC classification number: H05H13/04 ,  H05H7/10 ,  H05H2007/045 ,  H05H2277/11

Abstract: The invention comprises a charged particle beam acceleration and optional extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括带电粒子束加速度和与癌性肿瘤的带电粒子束放射治疗结合使用的任选的提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转子磁体，边缘聚焦磁体，集中磁场磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率， 并且即使在从同步加速器提取质子的过程中也允许同步加速器中的质子的持续加速。