摘要:
Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.
摘要:
A bottom wall 11 of a valve chamber 13 of an electric switching valve 10 includes a laminated structure having a bottom cover 11 to which pipe fittings 14, 15, 16 are connected; a valve seat 19 on which the valve ports 19C, 19D are opened and which an end wall of the valve body 20 slidably contacts; an intermediate plate 17 interposed between the bottom cover 11 and the valve seat 19 with communication openings 17D, 17E for connecting the pipe fittings 15, 16 to the valve ports 19C, 19D. At least one of the valve ports 19C, 19D is biased toward a rotation center of the valve body 20 against the center of the corresponding pipe fitting 15, 16.
摘要:
A laser beam machine comprising a chuck table for holding a workpiece and a laser beam application means for applying a laser to the workpiece held on the chuck table, wherein the machine further comprises a processing sound wave detection means for detecting processing sound waves generated when a laser beam is applied to the workpiece from the laser beam application means and a control means for judging whether a detection signal from the processing sound wave detection means falls within a predetermined permissible range.
摘要:
An electric sintering mold includes a clamping portion for clamping a powder material, the material clamped by the clamping portion being subjected to a pressure from a pressurizer and a pulsating electric current externally supplied, so that joule heat is generated within the material for sintering the material. The mold is formed of material containing metal boride having electroconductivity. An electric sintering apparatus using such mold and an electric sintering method utilizing such apparatus and mold are also disclosed.
摘要:
A suspension control device for a vehicle equipped with suspension dampers variable of damping coefficient, including: a means for storing a group of schedules each having a plurality of information units for controlling the variation of the damping coefficient of the damper; a means for generating a new schedule by hybridizing more than one of the schedules selected from the group according to a predetermined genetic algorithm including mutation based upon a fictionalization that the schedules are living individuals each having the plurality of information units as a set of genes; a means for evaluating each of the schedules under current operation environment of the vehicle to determine the ranking of the schedules in the group in improving a predetermined performance of the suspension; a means for adopting a highest ranked schedule for controlling the damping coefficient of the damper; a means for deleting a lowest ranked schedule to keep the number of the schedules forming the group substantially constant; and a means for generating a control signal for controlling the damper based upon the highest ranked schedule.
摘要:
A ski braking device is provided which includes a base plate, a brake member which is rotatably supported by the base plate, a pedal member connected to the brake member, and a metal member which extends from the base plate into a hollow space located in the pedal member. The metal member is made up by a metal rod and includes a first end portion which is rotatably supported by the base plate and a second free end portion which extends into the hollow space in the pedal member and which is hooked or bent toward the side edge of the ski plate. The pedal member includes first and second elastic pressure exerting members which are located in the hollow space which sandwich the second free end portion of the metal member between them.
摘要:
A heel piece of a ski safety binding which automatically opens when an excessive force is exerted on the ski boot. The heel piece includes a pair of arms pivotally connected to a base plate, a frame pivotally connected to a pivot pin extending between the pair of arms, which frame is displaceable along the axis of the ski, a heel holding member provided at the front end of the frame and a lock piece disposed in the frame and being displaceable along the axis of the ski relative to the frame. The lock piece has a cam surface which engages a lock pin provided between the pair of arms in a normal state of use. When a strong upwardly directed force is applied to the heel holding member as in a case of a forward fall of the skier, the frame and lock piece displace rearwardly and thereby brings the lock pin out of engagement with the cam surface of the lock piece, enabling the heel piece to rotate for releasing the heel of the ski boot. A release load can be adjusted by varying space defined between the frame and the lock piece.
摘要:
An image processing device adjusts black separately from chromatic colors and applies density adjustment capable of controlling the amount of color material according to the density. Such image processing device, capable of communicating with an image recording device, includes a color conversion unit that converts image data expressed in a first color space to color material amount data expressed in a second color space used by an image recording device; a density adjustment unit that increases or decreases the color material amount data based on a specified adjustment value; a dot breakdown unit that converts the increased or decreased color material amount data to dot quantity data expressed as a dot quantity for each of different sizes of dots formed by the image recording device; and a halftone process unit that converts the dot quantity data to data denoting whether or not the dots are formed.
摘要:
An image processing device adjusts black separately from chromatic colors and applies density adjustment capable of controlling the amount of color material according to the density. Such image processing device, capable of communicating with an image recording device, includes a color conversion unit that converts image data expressed in a first color space to color material amount data expressed in a second color space used by an image recording device; a density adjustment unit that increases or decreases the color material amount data based on a specified adjustment value; a dot breakdown unit that converts the increased or decreased color material amount data to dot quantity data expressed as a dot quantity for each of different sizes of dots formed by the image recording device; and a halftone process unit that converts the dot quantity data to data denoting whether or not the dots are formed.
摘要:
The surface-treated steel sheet has a zinc-based plated steel sheet, a surface-treatment coating being formed on the surface of the zinc-based steel sheet by applying and drying a surface treatment coating composition thereon, and a top coating being formed by applying and drying a coating composition for top coating on the surface-treatment coating. The surface treatment coating composition contains a water-epoxy resin dispersion, a silane coupling agent, and phosphoric acid and/or a hexafluorometal acid. The coating composition for top coating contains a high molecular weight epoxy group-containing resin having number average molecular weights ranging from 6000 to 20000.