公开(公告)号：US06486508B1

公开(公告)日：2002-11-26

申请号：US09568147

申请日：2000-05-10

申请人： Yong-Kyu Lee

发明人： Yong-Kyu Lee

IPC分类号： H01L29788

CPC分类号： H01L27/11521 ,  H01L27/115 ,  H01L29/42324

摘要： A non-volatile semiconductor memory device and the fabricating method thereof, wherein control gates respectively formed at the active areas of the resultant structure for getting a corresponding pair of split floating gates continuously overlapped and buried diffusion areas formed at the substrate of the periphery of the field insulating layer positioned between neighboring source areas to prevent the source areas from being electrically disconnected by the field insulating layer, even if the floating gate pattern and the control gate pattern are respectively made by separate processes, so that there will be no mismatching between the aforementioned two patterns, thereby leading to no tendency of showing different characteristics of memory cells in accordance with odd/even numbered word lines, the schematic characteristic of cells makes it possible to program and erase a byte, and one contact hole is not used at each bit line, the number of contact holes gets small, thereby making it possible to scale down cells.

摘要翻译： 一种非易失性半导体存储器件及其制造方法，其中分别形成在所得结构的有源区上的控制栅极，用于使对应的一对分离浮置栅极连续地重叠，并且掩埋形成在 位于相邻源极区域之间的场绝缘层，以防止源极区域被场绝缘层电断开，即使浮栅图案和控制栅极图案分别由单独的工艺制成，从而不会发生不匹配 上述两种图案，由此导致根据奇/偶数字线不存在显示存储单元的不同特性的趋势，单元的示意性特性使得可以对字节进行编程和擦除，并且每个不使用一个接触孔 位线，接触孔的数量变小，从而形成 可能缩小细胞。

公开(公告)号：US06245753B1

公开(公告)日：2001-06-12

申请号：US09300173

申请日：1999-04-27

申请人： Youngro Byun ,  Yong-Kyu Lee

发明人： Youngro Byun ,  Yong-Kyu Lee

IPC分类号： A61K31727

CPC分类号： C08B37/0075 ,  A61K31/727 ,  A61K47/542 ,  A61K47/554 ,  C08B37/00 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/905 ,  Y10S977/915

摘要： Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivatives were synthesized by conjugate to bile acids, sterols, and alkanoic acids, respectively. The hydrophobicity of the heparin derivatives depended on the feed mole ratio of heparin to hydrophobic agent. The heparin derivatives were slightly hydrophobic and exhibited good solubility in a water-acetone solvent, as well as water. The heparin derivatives have a high anticoagulant activity. These slightly hydrophobic heparin derivatives can be absorbed in gastric intestinal tract and can be used as oral dosage form. Also, the heparin derivatives can be used for the surface modification to prevent anticoagulation for medical devices such as extracorporeal devices and implanted devices.

摘要翻译： 广泛用作抗凝药物，特别是肝素的多糖由于其亲水性强，负电荷高，临床上仅通过静脉内或皮下注射给药。 两亲肝素衍生物分别通过与胆汁酸，甾醇和链烷酸共轭合成。 肝素衍生物的疏水性取决于肝素与疏水剂的进料摩尔比。 肝素衍生物略微疏水，在水 - 丙酮溶剂以及水中表现出良好的溶解性。 肝素衍生物具有高抗凝活性。 这些轻微疏水的肝素衍生物可以在胃肠道中被吸收并且可以作为口服剂型使用。 此外，肝素衍生物可用于表面改性以防止诸如体外器件和植入装置之类的医疗装置的抗凝。